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Biomedical subjects

M Kitagawa

Publications and source records attributed to M Kitagawa.

At least 703 records · Page 39Linked to original sources
PubMedDate not supplied

Influence of plasma lipids and adiposity on red blood cell tocopherol level.

The influence of plasma lipids and the degree of adiposity on red blood cell (RBC) tocopherol levels was investigated in children. In the first study of nonobese children with a wide range of plasma lipid values, the correlation coefficient between RBC tocopherol levels and plasma tocopherol levels was 0.39 (P less than 0.001, n = 195) but when RBC tocopherol was compared with plasma tocopherol based on plasma total lipids, the coefficient increased to 0.69. From this finding it is assumed that RBC tocopherol levels are governed by the tocopherol concentration in plasma lipids. In the second study of obese children, RBC tocopherol levels decreased in the children with 30% or more excess weight, as compared with those of control children and those with less than 30% obesity, while plasma tocopherol levels were unrelated to obesity grades. Because of no significant difference in plasma total lipid levels among these three groups of children, decreased RBC tocopherol in children with 30% or more obesity is probably attributable to their adiposity.

Adolescent↗
PubMedDate not supplied

Elevation of serum phospholipase A2 in patients at an intensive care unit.

To evaluate the organ specificity of pancreatic phospholipase A2 (PLA2) and the diagnostic value of the elevation of serum PLA2 levels in patients with serious diseases not involving the pancreas, we studied the organ distribution of PLA2 in autopsy specimens and serum level of PLA2 in patients who required admission to an intensive care unit (ICU). PLA2 was measured by a specific radioimmunoassay (RIA), using monoclonal antibody against human pancreatic PLA2. Organ distribution of PLA2 revealed that the pancreas showed a much higher content of pancreatic PLA2 immunoreactivity than any other organ. An abnormally high value of serum PLA2 was observed in 18 of 30 patients (60%) at ICU. Both serum PLA2 and pancreatic isoamylase were elevated in 11 patients (37%). Of 11 patients with hyperphospholipasemia and hyperamylasemia, serum creatinine was elevated in five patients and blood urea nitrogen in nine patients. Serum PLA2 levels did not always rise comparably to serum creatinine and blood urea nitrogen levels. Serum PLA2 values showed the best correlation with serum lactate dehydrogenase levels among routine blood-chemistry tests. The elevation of serum PLA2 was ascribable to renal dysfunction or ischemic pancreatic damage secondary to circulatory collapse with multiple organ failure.

Adult↗
PubMedDate not supplied

Palliation of pyloric stenosis caused by gastric cancer using an endoscopically placed covered ultraflex stent: covered stent inside an occluded uncovered stent.

A 71-year-old man developed pyloric stenosis caused by gastric cancer. Vomiting and nausea resolved after the insertion of an uncovered Ultraflex stent (length 10 cm, inner diameter 18-23 mm) through a 7-cm-long stenosis, and the patient was able to eat a soft diet. After 6 weeks, stent occlusion occurred due to tumor ingrowth and accumulation of food residue. Endoscopic observation showed a very narrow residual lumen. A covered Ultraflex stent (length 10 cm, inner diameter 18-23 mm) was inserted through the first stent and expanded to its maximum diameter over the next 2 days. The patient's vomiting and nausea improved rapidly. He died 6 months after the second stenting procedure, from metastatic tumor spread, having remained free of nausea and vomiting. In this case, a covered metallic stent prevented tumor ingrowth and maintained gastrointestinal patency.

Aged↗
PubMedDate not supplied

Nonlinear geometric warping of the mask image: a new method for reducing misregistration artifacts in digital subtraction angiography.

PURPOSE: Misregistration artifact is the major cause of image degradation in digital subtraction angiography (DSA). The purpose of this study was to evaluate the efficacy of a newly developed nonlinear geometric warping method to reduce misregistration artifact in DSA. METHODS: The processing of the images was carried out on a workstation with a fully automatic computerized program. After making differential images with a lapracian filter, 49 regions of interest (ROIs) were set in the image to be processed. Each ROI of the live image scanned the corresponding ROI of the mask image searching for the best position to match itself. Each pixel of the mask image was shifted individually following the data calculated from the shifts of the ROIs. Five radiologists compared the images produced by the conventional parallel shift technique and those processed with this new method in 16 series of cerebral DSA. RESULTS: In 14 of 16 series (88%), more radiologists judged the images processed with the new method to be better in quality. Small arteries near the skull base and veins of low density were clearly visualized in the images processed by the new method. CONCLUSION: This newly proposed method could be a simple and practical way to automatically reduce misregistration artifacts in DSA.

Angiography, Digital Subtraction↗
PubMedDate not supplied

Radiation exposure to interventional radiologists during manual-injection digital subtraction angiography.

PURPOSE: We investigated the relationship between the amount of radiation exposure to the operator during table-side manual-injection angiographic procedures including digital subtraction angiography (DSA) and the operator's position, as well as a simple means to decrease radiation exposure. METHODS: Measurement of radiation exposure was carried out with thermoluminescent dosimeters (TLDs) in nine abdominal angiographies. In the first study, radiation exposure during DSA or during fluoroscopy was measured using TLDs placed near the angiographic table. In the second study, radiation exposure to the interventional radiologist was measured during manual-injection DSA at a near and a far operator position. RESULTS: Radiation exposure to the operator received during manual-injection DSA accounted for more than 90% of the total procedural exposure. The exposure to the operator markedly decreased at the far position compared with that at the near position when performing DSA. CONCLUSION: Manual-injection DSA is the largest contributor to radiation exposure received by the interventional radiologist, therefore, the use of a power injector is always recommended when performing DSA. When manual-injection DSA is necessary, radiologists should position themselves as far away from the patient as possible.

Angiography, Digital Subtraction↗
PubMedDate not supplied

Autopsy cases of asbestosis in Japan: a statistical analysis on registered cases.

There are 525 (484 male, 38 female, 3 unknown) autopsy cases with asbestosis registered in the Annual of the Pathological Autopsy Cases in Japan, which is issued by the Japanese Society of Pathology for the years 1958-1996. The frequency of asbestosis (number of cases/total autopsy cases) was 0.017% (76/440,334) for the 1958-1979 time period, 0.058% (226/390,124) for 1980-1989, and 0.099% (223/225,801) for 1990-1996. There was a significant increase in asbestosis cases across the three time periods (p < .0001). The number of asbestosis cases increased markedly among individuals who worked with asbestos products, as well as among those employed in asbestos-processing factories. The frequency of malignant tumors associated with asbestosis was 61.0% (320/525), and the frequency also increased across the three time periods, from 43.4% (33/76) to 62.8% (142/226) and 65.0% (145/223), respectively. Among the 525 cases with asbestosis, there were 174 lung cancers (33.1%), 73 malignant mesotheliomas (13.9%), 29 stomach cancers (5.5%), 14 liver cancers (2.7%), 9 prostatic cancers (1.7%), 8 malignant lymphomas (1.5%), 6 laryngeal cancers (1.1%), 4 pancreas cancers (0.8%), 3 rectal cancers (0.6%), and 28 other cancers (5.3%). The frequencies of lung cancer, malignant mesothelioma, and laryngeal cancer were significantly higher in the cases with asbestosis than among the nonasbestosis cases. The number of malignant tumors related to asbestos exposure is expected to increase in the future.

Adult↗
PubMedDate not supplied

Asbestos fiber analysis in seven asbestosis cases.

Asbestos bodies and fibers deposited in the lungs of seven asbestosis cases were counted after tissue digestion. The types and sizes of 100 asbestos fibers for each case were also analyzed. Asbestos bodies were counted with an optical microscope at 100x magnification, and asbestos fibers were counted with a transmission electron microscope (TEM) at 2000x magnification. Most asbestos fibers detected with TEM were longer than 3 microns (92.5%) and thicker than 0.1 microns (92.3%). Short fibers less than 2 microns--both chrysotile and amphiboles, as well as long, thin fibers less than 0.06 microns--would be missed at 2000x (TEM). An average of 1.37 (0.081-5.5) x 10(6) asbestos bodies and 164.8 (0.55-610) x 10(6) asbestos fibers per 5 g wet (0.88 g dry) lung tissue were found, and these values are higher than what was reported in mesothelioma cases without asbestosis that were reported previously. More than 13 (average = 266.2) asbestos bodies were found in a 4-micron-thick tissue section (average area = 3.24 cm2). One asbestos body in a section equaled approximately 5,000 per 5 g wet lung tissue. The intensity of fibrosis was minimal in one case, mild in four, moderate and severe in one each, and the intensity was correlated with the number of asbestos bodies and fibers. The fibrosis in the severe case may have been intensified by repeated infection. Crocidolite fibers were found most frequently (84.7%), were thin, and had a high aspect ratio by our counting rules. Crocidolite with a high aspect ratio may be most fibrogenic in the lung.

Adult↗
PubMedDate not supplied

Asbestos fiber analysis in nine lung cancer cases with high asbestos exposure.

We examined the types and sizes of 100 asbestos fibers in lung tissue obtained from 9 lung-cancer cases (5 autopsy and 4 surgical) with more than 10(4) asbestos bodies per 5 g of wet lung tissue, asbestos bodies in histological sections, and the history of occupational asbestos exposure. Evaluation of asbestos fibers by transmission electron microscopy (2,000 x magnification) revealed that most fibers were longer than 3 microns (96%) and were thicker than 0.1 micron (93%). The analytical conditions we used enabled us to identify 99.7% of all asbestos fibers as being amphibole asbestos. Crocidolite fiber, which was found most frequently (73.1%), was the predominant type of fiber found in 8 of the 9 cases; crocidolite was followed by amosite (21.7%), which was the predominant type found in the remaining case. Crocidolite fibers were thin and had a high aspect ratio (mean diameter = 0.23 micron, mean aspect ratio [length/diameter] = 85.5). Amosite fibers were long, and they also had a high aspect ratio (mean length = 21.8 microns, mean aspect ratio = 66.4). It has been suggested that such fibers with a high aspect ratio are strongly carcinogenic to pulmonary parenchyma. Review of our previous and present data with respect to the ratio of amosite to crocidolite fibers in groups of subjects who had various diseases revealed that this ratio was relatively constant in some occupations. The more predominant fibers found were crocidolite in insulation workers and amosite in railroad workers. The ratio of amosite to crocidolite fibers should be considered in tissue-burden studies.

Adult↗