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Biomedical subjects

M Kishimoto

Publications and source records attributed to M Kishimoto.

At least 91 records · Page 5Linked to original sources

Germinoma originating in the basal ganglia. Report of a case showing unusual appearance on MRI.

A case of germinoma originating in the basal ganglia is presented. Preoperative MRI showed an area of a reticulated core of mixed signal intensity with a surrounding rim of low signal intensity in the right basal ganglia on T2-weighted image. This finding was reported to be characteristic of cavernous angioma, but the tumor was histopathologically identified to be a germinoma with old hemorrhage. The pitfall of MRI in diagnosing brain tumors is discussed.

Adolescent↗

Cardiac rupture following acute myocardial infarction in systemic lupus erythematosus: case report.

A thirty-three year-old woman with systemic lupus erythematosus (SLE) suffered from acute myocardial infarction. Prednisolone 20 mg/day was used because the signs of SLE, such as fever and decreased serum C3, levels, became aggravated on the fifth hospital day of acute myocardial infarction. Fatal cardiac rupture occurred on the twenty-second hospital day. At autopsy, extensive myocardial infarction with coronary artery thrombi and diffuse coronary arteritis were revealed. The rare clinical picture of a fatal cardiac rupture in the later phase of acute myocardial infarction and the precise dosage of prednisolone for her SLE are described.

Adult↗

[A case report of anterior crowding treated without extraction].

In orthodontic diagnosis, one of the most important factors is to decide whether or not to extract permanent teeth. There are many so-called borderline cases. In analyzing and determining whether or not to extract, discrepancy, profile, growth, and the patient's understanding and cooperation must be considered. We treated a borderline case without extraction, and established good occlusion and profile. Soft tissue changes are chiefly discussed.

Child↗

Dot microfiltration sandwich EIA for the measurement of IGM concentrations in cerebrospinal fluid.

A sensitive and simple sandwich enzyme immunoassay (EIA) using a dot microfiltration apparatus has been developed for the measurement of immunoglobulin M (IgM) concentrations in cerebrospinal fluid (CSF). The lower detection limit was 0.5 micrograms/dl. We applied this method to the testing of 200 CSF samples with normal concentrations of albumin, IgG and total protein, and normal cell counting. The non-parametric 2.5 and 97.5 percentile limits of IgM and the IgM index were 6.1-64.3 micrograms/dl and 0.012-0.063, respectively. We also applied this method to the testing of samples from 11 cases of multiple sclerosis (MS) and 15 cases of Guillain-Barré syndrome (GBS). High values for IgM and the IgM index were observed in 18.2% and 9.1% of MS, respectively and in 66.6% and 20.0% of GBS, respectively.

Evaluation Studies as Topic↗

[Case of bimaxillary protrusion and lip evaluation on cephalogram].

One of the goals of orthodontic treatment is to obtain the best balance and harmony of facial lines, especially it is important to retract the lip in bimaxillary case. A 12-year and 4-month-old boy was first seen with the chief complaint of excessive lips protrusion. We treated him by the edgewise method for 34 months, and evaluated the change of facial profile. Excessive lip protrusion was eliminated, and arch leveled. Overjet and overbite were reduced. Mandibular growth increased the prominence of the chin, and reduce the protrusion of the lower lip.

Humans↗

[Prediction of coronary artery disease using post exercise T wave change].

In the evaluation of the exercise stress test, conventional electrocardiographic criteria using 1 or 2 mm ST segment depression below the isoelectric line yields many false positive results and is not so useful to predict the severity of coronary artery disease. In this study, we have attempted to predict the presence and the severity of coronary artery disease from the post exercise T wave change. Fifty-six patients who had positive treadmill exercise test results by conventional ST segment criteria and underwent selective coronary arteriography were studied. T wave change was defined as inversion or biphasic change in one or more of leads aVF, V4, V5, V6 during the recovery phase, and in the cases who showed T wave changes, T wave configuration were also analysed. Seventeen of 28 patients with and 11 of 28 patients without significant coronary artery disease showed post exercise T wave changes. This difference was not statistically significant. But in the cases who showed T wave changes, the maximum amplitude of the negative component of T wave was significantly greater in the true positive group than in the false positive group. And the development of deeply negative component (more than 1.5 mm) indicated the presence of multivessel coronary artery disease. In the cases who showed the negative component of T wave less than 1 mm, the characteristics of T wave configuration including the amplitude, height of positive component, and the depth from the isoelectric line were different between the 2 groups. These results suggest that careful observation of T wave during the recovery phase is useful to improve the diagnostic accuracy of the exercise electrocardiogram.

Adult↗

[Neo-adjuvant chemotherapy with UFT and adriamycin in head and neck cancer].

Thirty-one patients with head and neck cancer were administered pretreatment induction chemotherapy (so-called neo-adjuvant chemotherapy) consisting of a UFT and ADM combination. The chemotherapy consisted of ADM (0.5 mg/kg b.w.) once a week up to 3 times, and UFT (600 mg/day) every day for 20 days. Overall response rate was 37.9% (11/31), and 1 CR and 10 PR were obtained. After definitive treatment, the primary control rate was 80.6% (25/31). Sixteen primary lesions in the 31 patients were classified according to Shimosato's grading system into 1 grade IV, 5 grade III and 10 grade II b a-I. Lymph-node metastases in 5 cases were also classified. The grading of lymph-node metastases was lower than that of the primary lesions.

Adult↗