Biomedical subjects

M Kishikawa

Publications and source records attributed to M Kishikawa.

94 records · Page 6Linked to original sources

PubMedDate not supplied

Herbal medicine and the study of aging in senescence-accelerated mice (SAMP1TA/Ngs).

Two types of herbal medicine, Toki-Shakuyaku-San (TSS) and Boui-Jiou-Tou (BJT), were considered from the view point of their possible preventive effect on senility using the Senescence-Accelerated Mouse (SAMP1TA/Ngs), which is thought to be a useful model of human aging. The investigation of the effects of TSS and BJT on the behavior, learning ability, longevity, and histological changes in animals may be important for basic studies on aging in humans. Pellet feed containing each herbal medicine was given to the treated group ad libitum for 24 weeks starting at the age of six weeks. Learning ability and the longevity of mice were assessed and spontaneous motor activity was also measured. Morphological examinations were performed. On the passive avoidance task, the period until acquisition of standard achievement rate was shorter in the treated groups than in the control groups. The mean number and the density of dendritic spines were higher in the BJT treated group than in the control group. With regard to life span, median survival time tended to be longer in the treated groups than in the control groups. The results of this study suggested that TSS and BJT have some valuable effect for the prevention of senility.

Aging↗

PubMedDate not supplied

Intraneuronal eosinophilic bodies of beef cattle (Japanese brown).

Eosinophilic cytoplasmic inclusion bodies were observed in the midbrain, pons, medulla and spinal cord of beef cattle (Japanese Brown). The inclusion bodies, observed in 14 of 20 cases exhibiting neurological signs and in one of nine healthy cases, differed in morphology and/or staining properties from previously reported inclusion bodies in humans and animals.

Animals↗

PubMedDate not supplied

Crow-Fukase syndrome associated with extramedullary plasmacytoma.

A patient with extramedullary solitary tumor had progressive sensory motor neuropathy, generalized pigmentation of skin, pretibial edema and gynecomastia. Serological examination of this patient showed monoclonal IgA-lambda gammopathy. Histologically, the tumor was defined as an IgA (lambda type) positive extramedullary plasmacytoma by using peroxidase anti-peroxidase staining. The tumor was accompanied by angiofollicular lymphoid hyperplasia. Pathologically, it was recognized as an extramedullary plasmacytoma associated with Castleman's disease like changes, and was successfully treated by surgical resection, followed by irradiation.

Aged↗

PubMedDate not supplied

Malignant peripheral nerve sheath tumors developing multifocally in the central nervous system in a patient with neurofibromatosis type 2.

We describe autopsy findings of multifocal malignant peripheral nerve sheath tumors (MPNSTs) appearing in the central nervous system in a 45-year-old Japanese female with neurofibromatosis type 2. Multiple MPNSTs were detected in both III and VIII, left IV, and V cranial nerves, and a number of nerve roots of the spinal cord. Neurofibromata were on the other hand evident on some nerve roots of the spinal cord and femoral and sciatic nerves. Our results suggest that a mutation of p53 gene may have played a role in the malignant transformation of nerve tumors in this patient since p53 protein was immunohistochemically detected in MPNST cells but not in tumor cells of the neurofibromata.

Fatal Outcome↗