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Biomedical subjects

M Kirkpatrick

Publications and source records attributed to M Kirkpatrick.

48 records · Page 3Linked to original sources
PubMed1980

Gas chromatography mass spectrometry computer analysis of volatile halogenated hydrocarbons in man and his environment--A multimedia environmental study.

As part of a study to make a comparative analysis of selected halogenated compounds in man and the environmental media, a quantitative gas chromatography mass spectrometric analysis of the levels of the halogenated compounds found in the breath, blood and urine of an exposed population (Old Love Canal area, Niagara, New York) and their immediate environment (air and water) was undertaken. In addition, levels of halogenated hydrocarbons in air samples taken in the general Buffalo, Niagara Falls area were determined.

Air Pollutants↗
PubMed1976

Treatment of requests for sex-change surgery with psychotherapy.

The authors describe two patients whose requests for sex-change surgery represented crises in sexual identity and anxiety-masking symptoms. Brief psychotherapy enabled these patients to relinquish their belief in a surgical "cure". In evaluating such request, the psychiatrist should consider the patient's total personality rather than focusing on the genuineness of the perceived gender disorder. Whatever the final decision, the opportunity for continued psychotherapy should be provided.

Adolescent↗
PubMedDate not supplied

Is the objective assessment of cerebral palsy gait reproducible?

It is important to determine the reproducibility of objective measures of gait in children with motor disorders in order that the effect of interventions to improve gait can be monitored. Data for walking velocity and vertical ground reaction force expressed as a percentage of body weight were collected from 15 normal children and 11 with spastic cerebral palsy. Five recordings were obtained for each foot of each child on 3 consecutive days, and calculations of variability made for each set of five recordings. Children with cerebral palsy had slower walking velocities and greater ground reaction force values, and both these parameters had low intraindividual variation for both normal children and those with cerebral palsy (coefficients of variation < 12.5%). This good reproducibility applied to intrasubject and intraday variability; no learning effect was seen over 3 days' recordings. There was no significant difference in variability whether the first three recordings or all five were used. These techniques of gait measurement in children have good reproducibility and a potential role in the objective assessment of medical and surgical interventions.

Cerebral Palsy↗
PubMedDate not supplied

The false negative rate in cervical cytology. Comparison of monolayers to conventional smears.

OBJECTIVE: To compare cervical monolayers prepared by a density gradient technique to conventional smears. STUDY DESIGN: The study evaluated 2,863 patient samples. After conventional smears were prepared, the residual samples (collected in preservative fluid) were processed by the monolayer preparation system, which disaggregates the cells, removes nonclinical debris and layers the diagnostic material onto a microscopic slide. Slides were screened in Germany and the United States in masked studies. RESULTS: In the U.S. study, the false negative rate for the conventional smears was 9.4% when endocervical components were present and 16.7% when absent. The false negative rate for the monolayer preparation was 4.0% when endocervical components were present and 5.7% when absent. A comparison of the diagnostic results showed that the monolayer made possible the detection of 48 cases of low grade disease or higher that were not found on the conventional smear. The German study was independent but used the same samples. The results, although based upon the Papanicolaou classification, were similar. CONCLUSION: Cervical samples that are preserved in a liquid suspension and prepared using the density gradient monolayer technology have many advantages over conventional cervical cytologic smear preparations. The quality of cell preservation and presentation is superior. Elimination of obscuring material, homogeneity of the sample and standardized quality work together to produce preparations that can be effectively and reliably screened by cytotechnologists. These preparations should greatly enhance the reliability of machine-based screening in the future.

False Negative Reactions↗