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Biomedical subjects

M Kirchgessner

Publications and source records attributed to M Kirchgessner.

At least 271 records · Page 15Linked to original sources
PubMed1979

[Activity of different dehydrogenases and alkaline phosphatase in manganese deficiency].

The enzyme activities of the isocitrate, glucose-6-phosphate and malate dehydrogenases and of malic enzyme in liver, of lactate dehydrogenase in serum, and of alkaline phosphatase in bone and serum were determined in early-weaned rats given different Mn supplies. The activities of malate dehydrogenase were reduced by 16 and 18% during suboptimum and deficient Mn supply, respectively, the values of alkaline phosphatase in serum and bone were elevated by 29 and 35%, respectively. The enzyme values of the glucose-6-phosphate and lactate dehydrogenases were elevated only during Mn deficiency (by 40 and 65%, respectively), while a suboptimum Mn supply had no noticeable influence on these enzymes. The activities of isocitrate dehydrogenase and of malic enzyme, which were described to be activated by Mn++ in vitro, did not respond in vivo to Mn deficiency.

Alkaline Phosphatase↗
PubMed1979

[Changes in zinc retention in pregnancy].

Enhanced retention of nutrients in the gravid organism, which exceeds the normal deposition in the reproductive organs and in fetuses, is called 'pregnancy anabolism'. For zinc this superretention could be established only in the liver which was enlarged in gravid rats, too. In all other tissues of gravid animals, zinc contents were lower compared with nongravid rats. After lactation, these changes in zinc status were equalized, and gravid and nongravid animals showed the same values.

Animals↗
PubMed1979

[Enhanced retention of zinc in the gravid organism].

Enhanced retention of nutrients in the gravid organism, which exceeds the normal deposition in the reproductive organs and in fetuses, is called 'pregnancy anabolism'. For zinc this superretention could be established only in the liver which was enlarged in gravid rats, too. In all other tissues of gravid animals, zinc contents were lower compared with nongravid rats. After lactation, these changes in zinc status were equalized, and gravid and nongravid animals showed the same values.

Animals↗
PubMed1978

[Copper and zinc contents in milk and plasma of cows after high nutritional copper supplements].

In three feeding trials with dairy cows over periods of six weeks each, it was studied whether very high nutritional supplements of copper alter the copper and zinc levels of milk and plasma. The supplemented groups with an average milk yield of 20 kg were given CuSO4 X 5H2O at levels varying from 250 to 550 mg copper per cow and day over and above the amount supplied by the commercial winter ration (300 mg copper and 1200 mg zinc). There was no significant influence of the copper supplementation on the copper and zinc contents of milk compared with the untreated control animals. On the average for all experimental weeks, copper contents of 0.15--0.20 mg and zinc content of 4.0--4.6 mg/kg milk were recorded for the various experimental groups. The mean copper contents in plasma varied from 1.00 to 1.18 microgram/ml in the copper-supplemented groups and from 0.93 to 1.09 mircogram/ml in the control groups. The corresponding mean values for zinc ranged from 0.93 to 1.18 microgram/ml. Analysis of variance did not show any significant differences between the experimental groups nor any interactions between the copper and zinc contents. These results were discussed in relation to the dietary supply status.

Animals↗
PubMed1978

[Interaction among the trace elements zinc, copper and iron after depletion and repletion of dairy cows with zinc].

Imbalances in the supply with trace elements may be caused by the excessive administration of one or several elements or the insufficient administration in relation to other trace elements. This article deals with the interactions between the trace elements zinc and copper resp. zinc and iron under the conditions of the insufficient supply with Zn (6 mg per kg dry matter of the fodder) and the supply according to the demand with other trace elements (14 mg copper resp. 83 mg iron per dry matter of the fodder). For this purpose we investigated the copper, iron and zinc content of the milk and the serum of cows that were first depleted of zinc through a semi-synthetic zinc deficiency diet and then repleted with extra allowances of zinc. The closest connections exist between the copper and zinc content of the milk. Thus extreme Zn-deficiency feeding conditions the decreased Zn-content on the one hand and increased Cu-content on the other. In contrast to this, the cows' Zn-excretion in the milk increases after Zn-repletion whereas the Cu-content decreases. This shows a distinctly negative correlation. A loose connection could only be detected for the Cu- and Zn-content of the serum. Though the Zn-content changed considerably in dependence on the Zn-supply, the Cu-content remained largely uninfluenced. The Fe-content of both milk and serum shows no interaction with the nutritive Zn-supply. Only after 19 test weeks of extreme Zn-deficiency could a slight increase of the Fe-concentration be indicated.

Animals↗
PubMed1978

[Conception of female rats and litter mortality due to Mn-deficiency].

Sexually mature, female rats were fed an Mn-deficient (1.0 ppm) diet on saccharose/casein basis and studied for their reproductive behaviour. Cycle disorders as sometimes described of females depleted over a longer period, were not observed in any case. Although the experimental animals showed a normal estrus, only 50% of the rats conceived. The rats that had become pregnant produced litters of 2 to 11 animals born alive. However, their mortality was 80%. They died either immediately after birth or during the first days post partum.

Animal Nutritional Physiological Phenomena↗