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M Kiernan

Publications and source records attributed to M Kiernan.

At least 37 records · Page 2Linked to original sources
PubMed1997

Can we identify who will adhere to long-term physical activity? Signal detection methodology as a potential aid to clinical decision making.

Signal detection methodology was used to identify the best combination of predictors of long-term exercise adherence in 269 healthy, initially sedentary adults ages 50-65 years. Less educated individuals who were assigned to supervised home-based exercise of either higher or lower intensity and who were less stressed and less fit at baseline than other individuals had the greatest probability of successful adherence by the 2nd year. Overweight individuals assigned to a group-based exercise program were the least likely to be successful 2 years later. Predictors of short-term (1-year) adherence were generally similar to predictors of 2-year adherence. Signal detection analysis may be useful for identifying subgroups of people at risk for underadherence who subsequently might be targeted for intervention.

Aged↗
PubMed1997

Degrees of safety.

Explore the source record for details and available documents.

Cross Infection↗
PubMed1995

Reproducibility of a heteronymous monosynaptic reflex in biceps brachii.

The present study provides normal data for a new technique to assess conduction across the C5/C6 segments by recording a heteronymous monosynaptic reflex response from the contracting biceps brachii in response to stimulation of the median nerve in the cubital fossa. The reflex responses were reproducible and symmetrical, with a mean latency of 14.8 msec (S.D. 1.4 msec) and an absolute side-to-side differences of 0.5 msec (S.D. 0.29 msec). Latency was significantly correlated with both age and height, and multiple regression analysis provided the following equation: latency (msec) = 0.091 x height (in cm) + 0.036 x age (years) - 1.988. Amplitudes had wide scatter (22-365 microV on the right side) and positive skew. An amplitude less than 40% of that for the other side would be outside the 90th percentile. Five cases are described to illustrate the potential clinical utility of this test. However, whether this reflex is of diagnostic value can be answered only by a prospective study comparing it with other routine investigations.

Adult↗
PubMed1994

Intact splenic function in cystic fibrosis.

Patients with cystic fibrosis (CF) suffer from severe chronic pulmonary infections but rarely develop bacteremia/septicemia suggestive of an intact splenic mononuclear phagocyte function. The splenic function of 25 patients diagnosed with CF, aged 2 to 37 years, was evaluated using erythrocyte pit count by direct interference contrast microscopy. Results were compared with patients with sickle cell disease and normal individuals. All CF patients displayed normal splenic function by pit count. The mean percentage of pitted erythrocytes was 0.20 +/- 0.28 (range: 0.0% to 1.0%) versus 0.19 +/- 0.33 (range: 0.0% to 1.4%) in normal eusplenic controls. There were no episodes of bacteremia or septicemia despite recurrent acute exacerbations of chronic bacterial bronchitis and the use of central lines. We conclude that splenic function in CF is unabridged and may account for the rarity of bacteremia/septicemia in patients with CF despite the high prevalence of chronic bronchial infection in this population.

Adolescent↗
PubMed1993

Decreased fat content and increased lean in pigs treated with antibodies to adipocyte plasma membranes.

Antibodies were prepared in sheep against purified plasma membranes from pig adipocytes. Western (immuno) blotting revealed reactions of the antisera with a large number of proteins in adipocyte plasma membranes but remarkably few in plasma membranes from muscle, kidney, liver, lung, brain, spleen, and erythrocytes. This illustrated the high degree of specificity the serum had for adipose tissue. When injected into localized subcutaneous sites such antisera were able to cause considerable adipocyte destruction, which resulted in complete loss of adipose tissue from the site for > or = 14 wk. This cell destruction was probably mediated in part by lymphocytic infiltration. Subcutaneous injections were of limited use because of the localized nature of the effects, but, when treatment was administered intraperitoneally, systemic effects were produced that resulted in a 30% reduction in backfat thickness in the region of the last rib and a 25% reduction in fat content of fore- and hind-loin joints that resulted in a significant increase in the percentage of lean tissue. Total feed intake, live weight gain, hot carcass weights, and dressing percentage were unaffected. These results demonstrate the potential for producing long-term reductions in body fat in pigs by an immunization technique that may also provide the unexpected, potential benefit of increased lean deposition. This suggests that fat deposition per se exerts a restrictive influence on lean carcass development.

Adipose Tissue↗
PubMed1992

Relation of level of exercise, age, and weight-cycling history to weight and eating concerns in male and female runners.

We examined the association between level of exercise and degree of weight preoccupation in a large sample of male and female runners, as well as risk factors posited to influence weight and eating concerns in the general population. Subjects were 2,459 males and 1,786 females who had completed a questionnaire on weight and eating concerns in a national running magazine. Eight percent of the males and 24% of the females had symptomatic scores on the Eating Attitudes Test (EAT). Exercise level, defined as weekly running mileage, was positively associated with excessive weight and eating concerns in males but not in females. Both sexes with a history of weight cycling were more likely to have symptomatic EAT scores than those with no such history. These results highlight the importance of studying these concerns in males as well as females and of examining the role of exercise level and weight-cycling history in the development of serious weight preoccupations.

Adolescent↗
PubMed1992

Immediate-startle stimulus presentation fails to condition freezing responses to contextual cues.

Twenty-eight male Wistar rats were placed in a novel and distinctive environment. Eighteen of these received an intense startle-eliciting white noise stimulus. Animals that experienced a 60-s delay between placement and the startle stimulus demonstrated significant freezing in the context, both poststartle (Session 1) and on a later startle-free test (Session 2). Animals that received immediate startle, however, did not differ on either occasion from animals that did not experience the startle stimulus. The amplitude of the startle response was not affected by this manipulation, which indicates a dissociation between freezing and startle responses with immediate- versus delay-startle presentation. The findings are consistent with Fanselow's (1986) conditioned stimulus-based associative explanation of the immediate-shock freezing deficit.

Animals↗
PubMed1992

Flow volume loops in patients with goiters.

Plain radiology is the standard means of assessing upper airway obstruction in patients with goiters. Flow volume loop curves will provide additional information, because they allow a quantitative assessment of airflow dynamics in the respiratory cycle. Fifty-one patients had flow volume loops performed before and after thyroidectomy. There was a significant increase in the maximum inspiratory flow rate (3.9 +/- 0.2 versus 4.9 +/- 0.2 L/second, p less than 0.01) after thyroidectomy. Eight of twelve patients with normal tracheal radiology had improved airflow dynamics in the postoperative period. The flow volume loop curve is a simple noninvasive means of assessing airflow dynamics in patients with goiters and may be superior to conventional radiology.

Adolescent↗
PubMed1992

Upward mobility for LPNs: a vision made reality.

A recurrent theme in the nursing literature is the shortage of realistic, long-term solutions directed toward registered nurse (RN) recruitment and retention. If fragmentation of RN recruitment and retention is to be eliminated, innovative programs involving collaboration and use of existing resources will be required. This article provides an overview of how collaboration among nurses, administrators, educators, and a personnel specialist resulted in an upward mobility program for licensed practical nurses (LPNs) to become RNs. While the program is specific to one setting, there are numerous implications for other hospitals confronted with persistent recruitment and retention problems.

Career Mobility↗
PubMed1990

The endocrine-paracrine cells of von Brunn's nests and glandular metaplasia in the supramontanal prostatic urethra.

Endocrine-paracrine (EP) cells are normal cellular constituents of the human genitourinary tract. We examined the distribution and immunostaining profile of EP cells in von Brunn's nests and glandular metaplasia in the supramontanal (proximal) prostatic urethra of adult males and in prostatic ducts of the male fetal urethra. In 15/17 transurethral prostatic resection specimens there were argyrophilic cells and/or serotonin and neuronspecific enolase containing cells in von Brunn's nests/glandular metaplasia and in the supramontanal prostatic urethra. All seven fetal specimens examined contained EP cells and five had focal calcitonin immunoreactivity in prostatic ducts and ductal buds. One adult resection specimen had focal staining for human chorionic gonadotrophin and no case showed staining for somatostatin. These results further support the contention that von Brunn's nests and glandular metaplasia are probably normal urothelial variants in the adult supramontanal prostatic urethra.

Calcitonin↗
PubMed1989

Economic predictors of mental health service utilization: a time-series analysis.

This research was designed to understand the relationships between economic indicators and mental health service utilization. Six monthly and three quarterly time-series analyses were done to assess the time-dependent association between three state-level economic indices and two measures of mental health service utilization. Consistent with the existing literature, increases in manufacturing employment were inversely related to both first admissions in state hospitals and case openings in community outpatient facilities. Labor force participation was also inversely related to first admissions to state hospitals. No relationship was found between service employment and either of the mental health service use indices. The specific findings suggest that two processes may be operating in the relationship of labor force participation and manufacturing employment with mental health service utilization. Some of the findings suggest a "crisis" process, in which service use increases rapidly following an economic stressor, whereas other findings suggest a more insidious process, in which economic stressors slowly weaken the mental health of the community and eventually lead to increased mental health service use. These results can be used to better inform social policy and preventive interventions by highlighting the human costs of changes in economic well-being. The need for more ecological research is discussed.

Adaptation, Psychological↗
PubMed1987

Brunn's nests and glandular metaplasia: normal urothelial variants in the supramontanal prostatic urethra.

Sections of 292 transurethral prostatic resection specimens and 52 intact prostatic urethral specimens from male patients 10 to 89 years old were examined for the presence of Brunn's nests and glandular metaplasia in the urothelium of the supramontanal prostatic urethra. The complex pitted urethral mucosa at and below the verumontanum was not assessed. Either or both lesions were present focally in 211 transurethral prostatic resection specimens (72 per cent) and in 51 intact urethral specimens (97.5 per cent). Brunn's nests and glandular metaplasia consisted chiefly of transitional cells but in 47 transurethral prostatic resection cases glandular metaplasia contained prostatic acinar-type cells and in 1 case intestinal-type goblet cells were noted. Brunn's nests and glandular metaplasia were associated with inflammation in only 27 per cent of the cases and were not associated with dysplasia or urethral tumors except for 1 benign papilloma. We conclude that Brunn's nests and glandular metaplasia are so common in the supramontanal prostatic urethra that they represent normal urothelial variants in this segment of the urinary tract.

Epithelium↗