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Biomedical subjects

M Kieffer

Publications and source records attributed to M Kieffer.

35 records · Page 2Linked to original sources
PubMed1981

IgA anti-gliadin antibodies in coeliac disease.

Sixty-two sera from children under investigation for gastrointestinal disease were tested for IgA, IgG and IgM antibodies to gliadin by two different methods: an immunofluorescent (IF) test, and a mixed reverse (solid-phase) passive antiglobulin haemadsorption (MRSPAH) test. There was good agreement between the tests. Both tests detected gliadin antibodies of IgG and IgA class in sera from children with active coeliac disease, which tended to disappear when a strict gluten-free diet was instituted. Serum antibodies to gliadin of IgA class were associated with severe small intestinal villous atrophy and were found almost exclusively in coeliac disease. Gliadin antibodies of IgG class were less disease-specific and were occasionally detected in sera from children with gastrointestinal disease other than coeliac disease--notably in sera from children with transient gluten intolerance.

Adolescent↗
PubMed1979

Nickel sensitivity: relationship between history and patch test reaction.

The prevalence of nickel sensitivity in 415 young adults was examined by patch testing with nickel sulphate 5% in pet. Before testing the persons filled in a questionnaire about personal or family history of atopy and skin reactions after metal contacts. Nickel sensitivity was found in 2.8% of males and 9.8% of females; 13 out of 28 persons with a history of metal contact dermatitis had negative patch test reactions to nickel; eight out of 23 persons with positive patch test reactions to nickel had never experienced skin reactions from metal contacts. These findings indicate that nickel sensitivity cannot be reliably predicted from pretest historical information.

Adult↗
PubMed1978

A study of skin diseases in dogs and cats. V. The intradermal test in the diagnosis of flea allergy in dogs and cats.

A group of 143 dogs and cats with pruritic skin disease was tested by intradermal injection of a dilute whole cat flea extract. The test results were correlated with the clinical diagnosis (Table I, III), with previous or present findings of fleas on the animals (Table II, III), with the presence or absence of blood eosinophilia (Table IV), and, in animals with clinical flea allergy, with the histological findings in a skin biopsy excised from a clinically affected skin site (Fig. 1). The predictive value of a positive and a negative outcome of the test was assessed graphically by means of calculations described in the Appendix (Figs. 2, 3). It is concluded that the test is sufficiently specific to justify its use in animals where flea allergy is suspected but cannot be proved by routine clinical examination. The histological findings and the nature of the skin reactions suggest that a positive outcome of the test is indicative of an immediate, type I hypersensitivity towards components of the oral secretion of fleas and that this hypersensitivity is mediated by reaginic antibody which to some extent is produced by plasma cells located in skin areas where flea saliva is deposited.

Animals↗