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Biomedical subjects

M Kettlewell

Publications and source records attributed to M Kettlewell.

23 records · Page 2Linked to original sources

Effect of digoxin on human red blood cell electrolytes.

Red blood cell electrolytes were measured during 48 h after administration of digoxin to twelve patients. The concentrations of some red cell electrolytes changed: sodium increased while potassium decreased significantly. These findings agree with in vitro experiments on red cells and other tissues including myocardium. Change in membrane ATPase activity is probably responsible for the electrolyte changes both in vitro and in vivo.

Digoxin↗

Total parental nutrition using conventional and medium chain triglycerides: effect on liver function tests, complement, and nitrogen balance.

Conventional long chain triglyceride (LCT) was compared with a new emulsion containing 50% medium chain triglyceride (5% MCT/5% LCT) in a randomized cross-over trial of 10 days duration. Plasma concentrations of albumin, prealbumin, the complement components C3 and C4, and prothrombin times measured daily at 8 am, before lipid infusion, showed no progressive change during the 10 days of the trial, nor in each separate 5-day period when LCT or MCT/LCT was infused. Aspartate transaminase and alkaline phosphatase activities were similar over the two periods. There was a significant increase (compared with preinfusion levels) in C3 and C4 levels after 5 hr of either lipid infusion. Nitrogen balance was improved, and plasma bilirubin levels were lower on the regimen containing MCT/LCT.

Adult↗