Search PubMed⌕ Search

Biomedical subjects

M Kessler

Publications and source records attributed to M Kessler.

At least 415 records · Page 23Linked to original sources
PubMed1982

Accurate quantification of nonesterified and total cholesterol in plasma and urine from crude lipid extracts by stable isotope dilution and field desorption mass spectrometry.

Levels of free and total cholesterol were quantified in control sera and human urine using [2H7]cholesterol or [13C2]cholesterol as internal standard and field desorption mass spectrometry for the quantification. These analyses are performed using a crude chloroform extract without chromatographic separation of the constituents. Due to the extremely soft ionization conditions in field desorption, the constituents of the crude lipid extract predominantly form molecular ion species and only a very low amount of fragment ions of low relative abundance thus minimizing the possibility of ion overlap in the mass spectrum. Mass spectrometric quantification of cholesterol in two control sera resulted in data within the range of assigned concentrations. The standard deviations of the mass spectrometric data were around +/- 2%. Generally, 50 microliters of serum or plasma or 500 microliters of urine are extracted and the mass spectrometric quantification performed using an aliquot of 2-10%. A characteristic pattern of intact cholesteryl esters is also obtained.

Body Fluids↗
PubMed1982

[Measurement of aluminium in bone by pulse polarography (author's transl)].

Pulse polarography has been applied to the determination of aluminium in bone. The sensitivity, selectivity and reproducibility of the method are described. The results of bone aluminium concentrations in controls and in haemodialysed patients treated with aluminium compounds are discuted. Pulse polarography permits very precise measurements of aluminium impregnating bone.

Adult↗
PubMed1981

Chordoma with a predominant retrosacral tumor mass.

Chordomas are malignant tumors with lobulated structure which usually consists of vacuolated physaliferous cells in a mucoid stroma (Enzinger et al. 1969). These cells originate from remnants of the chorda dorsalis. Most chordomas are located either at the end of the vertebral column, i.e., in the sacrococcygeal region or at the base of the skull near the sphenooccipital synchondrosis. More than half of all tumors are located in the sacrococcygeal region. In contrast to most cases of sacrococcygeal chordomas which show a predominant presacral tumor infiltration we report on a patient suffering from a sacrococcygeal chordoma with a retrosacral tumor mass. Here, the presacral tumor infiltration became apparent only much latter. It was nevertheless of great prognostic relevance as tumor infiltration of the urinary bladder lead to lethal septicaemia.

Aged↗
PubMed1981

[Xeroradiography and conventional radiological methods in chronic polyarthritis (author's transl)].

Xeroradiograms and conventional radiographs of the hands of 50 patients with chronic polyarthritis were performed. These were compared with regard to the features which are found in chronic polyarthritis. There were no significant differences between xeroradiography and conventional radiology. Xeroradiography was a little better for demonstrating changes in the soft tissues and erosions, but conventional radiographs were superior in showing osteoporosis, cysts and the absorption of subchondral lamellae. In general, xeroradiography and conventional procedures were of equal value in the diagnosis of chronic polyarthritis. For practical purposes, conventional radiography is to be preferred and xeroradiography may be regarded as an additional procedure, particularly for the investigation of soft tissue changes.

Adult↗
PubMed1981

[Variety and ambiguity of bronchogenic carcinoma in radiology (author's transl)].

The prognosis of bronchogenic carcinoma depends on its histology and the time of its first diagnosis. The 5-year-survival rate after radiation treatment is 3-10%. It is much better for tumors detected and operated in an early stage, averaging 21%. The roentgenomorphology of central and peripheral bronchogenic carcinoma and the differential diagnosis is demonstrated on a selected group of 300 patients seen in the "Klinik und Poliklinik für Radiologie" in Munich between 1975 and 1979. In conclusion we think it not justified to hesitate performing bronchoscopy and/or percutaneous needle aspiration lung biopsy in cases of unclear peripheral or central pulmonary shadows, considering the low risks of the two procedures.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1981

[Oxygen tension in skeletal muscle in patients with reduced O2-carrying capacity (author's transl)].

In 10 patients (age: 31--72 years) oxygen supply of skeletal muscle was measured by pO2-multiwire technique. All patients suffered from chronic renal failure of differing etiologies and from chronic renal anemia. In muscle tissue 1,128 different O2-tensions were registered and the results were expressed as pO2-histograms. Seven of these pO2-histograms show a normal distribution, three are shifted to the left to lower O2-tensions. Therefore the microcirculation in the skeletal muscle of patients with chronic reduced O2-carrying capacity is largely undisturbed. The microcirculation is able to increase with exercise as shown by a shift to the right in the PO2-histogram. The use of the pO2-multiwire electrode is largely devoid of risk to the patient. Important pathological features may be demonstrated.

Carbon Dioxide↗
PubMed1981

[Importance of bone scanning with Tc 99m in the supervision of hemodialysis patients with chronic renal failure (author's transl)].

Bone uptake of 99 m Tc diphosphonate may allow early diagnosis of renal osteodystrophy. Our study deals with 53 patients treated by repeated hemodialysis and reveals scanning abnormalities in 75% of them. Bone scanning provides information which are not visualized radiologically, especially scattered or located pulmonary calcifications (15% in our series). It is valuable in the follow-up of bone changes and is part of the necessary investigations before carrying out parathyroidectomy.

Adult↗
PubMed1980

[Radiological and histological changes in the skeleton in systemic haematological diseases (author's transl)].

The findings at bone marrow biopsies in 5,000 patients with systemic haematological diseases were compared with the radiographic appearances. Haemoblastic conditions produce diffuse involvement of the bone marrow, whereas conditions characterised by limited infiltration, such as Waldenström's disease or Brill-Symmers' disease, produce some osteoporosis and only rarely bone destruction. Haemoblastic diseases with additional focal proliferation, such as myelofibrosis or myelosclerosis, multiple myeloma, highly malignant lymphomas and malignant granulomatosis produce circumscribed changes in the spongiosa which are readily recognised radiologically. In addition to generalised osteoporosis or sclerosis, one finds local areas of osteolysis or osteoplasia. Bone marrow biopsies in above-mentioned conditions indicate that they progress in a series of stages which correlate well with the radiological findings.

Bone Diseases↗
PubMed1980

[Breast parenchymal patterns and carcinoma risks (author's transl)].

Wolfe has suggested that there is a correlation between the pattern of the breast parenchyma and the risk of a carcinoma. This has been confirmed by some authors and denied by others. Our investigations of 905 cases could not confirm Wolfe's thesis and suggested his results were due to selection of cases. Our findings confirm the opinion expressed several times in the literature that the women with a breast parenchymal pattern P2 and DY regarded by Wolfe as high risk patients are not distinguished by an increased risk, but by the fact that existing carcinomas tend to be missed by radiologists.

Adult↗
PubMed1980

Aneurysm of main left coronary artery.

A 57-year-old man presented with exertional chest pain, and was found to have a saccular, lobulated aneurysm of the left main coronary artery associated with severe atherosclerotic vascular disease. This is the third similar case reported and the first case of atherosclerotic origin. All symptoms were relieved by coronary artery bypass surgery.

Aneurysm↗
PubMed1980

[Effect of azathioprine and prednisolone on recipients of xenografts presensitized with donor species-specific antigen (author's transl)].

Presensitization induced by pretreatment of the recipients with donor species-specific spleen antigen cannot be completely reversed by immunosuppressive drugs. However, there is a suppressive influence of the combined administration of azathioprine and prednisolone on hemagglutinating antibody production after transplantation as well as an effect on function and survival time of renal xenografts.

Animals↗
PubMed1980

[Effect of anti-donor lymphocyte globulin on renal xenograft survived (author's transl)].

This paper reports about experimental xenografting of kidneys in closely related species (fox-dog) modifying primary rejection by treatment of the recipients with anti-donor lymphocyte globulin (ADLG). In respect of the phylogenetic constellations, ADLG contains lymphocytotoxic and hemagglutinating antibodies reactive in vitro with lymphocytes and erythrocytes of foxes as well as of dogs. Furthermore, donor species-specific papain-separated lymphocyte antigen is capable of reducing cytotoxicity of ADLG by adsorption of its lymphocytotoxic antibodies. In vivo ADLG, used as single therapy, has an immunosuppressive effect on kidney graft survival, which results in significant prolongation of mean survival time (9.6 +/- 1.5 days, n = 5).

Animals↗
PubMed1980

The bite plate--an adjunct in periodontic and orthodontic therapy.

This report reviews bite plate therapy and describes several variations of bite plates. Bite plates may be useful as an adjunct to periodontic and orthodontic therapy. They may be used as a diagnostic appliance, to take mobile teeth out of trauma by disarticulating them, to allow teeth to extrude and shallow out associated osseous deformities, and to eliminate the superimposed occlusal trauma that may be caused by the parafunctional habits that can develop during orthodontic tooth movement. The change in vertical position of the dentition and the decrease in overbite are primarily due to eruption of the posterior teeth and not intrusion of the lower anterior teeth. The decrease in overbite may be accompanied by an increase in overjet and an alteration of the mesio-distal and bucco-lingual occlusal landmarks. In some cases the use of a bite plate may cause the development of an anterior open bite. Any such occlussal alterations produced by the bite plate should be corrected by occlusal adjustment or orthodontic therapy and occlusal adjustment.

Alveolar Process↗
PubMed1980

[Induction of partial immune tolerance in a closely-related species system by a single injection of papain-extracted, donor species specific, lymphocyte membrane antigens].

This paper reports of experimental xenografting of kidneys in closely related species (fox-dog) modifying primary graft rejection by single i.v. injection of donorspecies-specific lymphocyte antigen in soluble form. Papain treatment was used to separate histocompatibility antigens from lymphocytes of donors. This antigen, in vitro, is capable of reducing cytotoxicity of xeno-antisera by adsorption of their lymphocytotoxic antibodies. A single intraoperative i.v. injection of this antigen to the transplant recipients results in the subsequent failure of humoral antibody production, thus this antigen-mediated effect is thought to be a state of B-cell tolerance. Survival times are more than doubled in comparison to untreated controls and last in average 14.6 +/- 1.74 days (n = 5). Histological studies demonstrate rather well conserved renal parenchym with sporadic infiltrations of round cells.

Animals↗