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Biomedical subjects

M Keshavan

Publications and source records attributed to M Keshavan.

11 recordsLinked to original sources
PubMed1995

Case study: risperidone in children and adolescents with schizophrenia.

Schizophrenia in children is an uncommon disorder with devastating effects. Study of the efficacy of treatment with neuroleptics in children with schizophrenia is only now beginning, and there are limited studies on the effectiveness of novel neuroleptics on the positive and negative symptoms of schizophrenia in children. Four patients with schizophrenia, aged 12 to 17 years, were treated with risperidone (4 to 5 mg/day), a 5-HT2/D2 receptor blocking agent, to determine its effectiveness. Three patients had substantial improvement in their negative symptoms without side effects.

Adolescent↗
PubMed1994

Further evidence for olfactory identification deficits in schizophrenia.

Forty-seven schizophrenic patients and 36 normal controls, matched for smoking history, were administered the University of Pennsylvania Smell Identification Test (UPSIT) and the Picture Identification Test (PIT). Amongst subjects successfully completing the PIT, non-smoking schizophrenic patients had significantly lower UPSIT scores than non-smoking controls. Smoking history and diagnosis did not interact to produce any pronounced effect. No significant gender difference was found. These results suggest schizophrenics display decreased olfactory identification even if likely confounders are adequately controlled.

Adolescent↗
PubMed1994

Gender differences in how medical students learn to rate psychopathology.

The aim of this study was to examine factors influencing medical students' learning of psychopathology assessments during the psychiatric clerkship. The subjects included 122 third-year medical students participating in a 6-week psychiatric clerkship. They completed Brief Psychiatric Rating Scale ratings on short, focused interviews in a balanced design before and at the end of the clerkship. Deviation of their ratings from standard ratings by experienced psychiatrists constituted the dependent variables. Female medical students showed a clear significant improvement during the clerkship, whereas male students tended to experience a significant reduction in their accuracy. We conclude that there may be gender-related differences in these medical students' ability to assimilate and cope with the clinical experience of the psychiatric clerkship. The implications of these findings for psychiatry training are discussed.

Attitude↗
PubMed1990

Suicidal indicators in schizophrenia.

The clinical and sociodemographic profile of suicidal and nonsuicidal schizophrenia patients was investigated in 801 patients with this diagnosis seen at a comprehensive psychiatric facility between 1983 and 1987. Suicidal patients tended to exhibit depression, aggressiveness, substance abuse and a severe and progressive impairment in adaptive functioning.

Adolescent↗
PubMed1988

Cholinergic REM sleep induction by arecoline in normal subjects: relation to thyroid function.

Serum thyroid hormones and the speed of rapid eye movement (REM) sleep induction by the central muscarinic agonist arecoline were measured in 21 normal volunteers. The arecoline-REM induction latencies had a modestly significant negative correlation with free thyroxine index. This finding is discussed in the light of observations in animal studies that thyroid hormones stimulate central cholinergic neuronal function.

Adult↗
PubMed1987

The association of supersensitive cholinergic REM-induction and affective illness within pedigrees.

Based on the Rieder and Gershon (1978) biological genetic study paradigm we compared the prevalence of a putative vulnerability factor (rapid cholinergic REM sleep induction) between 35 affectively ill and 31 well first-degree relatives of 34 probands chosen on the basis of presence of primary affective illness and positive marker status. A significantly higher percentage of ill relatives (63%, 22 out of 35 subjects) had a supersensitive REM-induction response as compared to well relatives (22%, 7 out of 31 subjects). Since the current study does not rule out the effects of prior depressive episodes or treatment on cholinergic sensitivity, caution must be exercised in the interpretation of our findings.

Acetylcholine↗
PubMed1987

Sleep and depression.

Manifestations of sleep disturbances can potentially serve as external criteria for the diagnosis of specific subtypes of major depressive disorder (MDD). Depressed patients generally experience disturbances of sleep continuity and rapid eye movement (REM) sleep. Disturbances in nonrapid eye movement (NREM) sleep (stages III and IV) also occur. Characteristic of primary sleep disturbance in many depressed patients are shortened REM latency periods and instabilities in NREM sleep identified by increases in the number of stage shifts, decreases in the duration of stage III and IV sleep, and a shift towards lighter sleep stages (sleep efficiency disturbances). Treatment modalities for these sleep disturbances include sleep deprivation therapy and antidepressant therapy. Sleep deprivation alone has been only moderately successful, while antidepressant therapy usually results in symptomatic improvement. To restore normative sleep, REM sleep periods and stage III and IV sleep must be returned to normal. Trazodone therapy has been shown to reduce the frequency of arousals, the severity of drowsiness, and the duration of REM sleep, and increase restorative slow wave sleep and stage III and IV NREM sleep.

Depressive Disorder↗