A DEMONSTRATION OF ANTIBODY ACTIVITY ON MICROSOMES.
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Journal Article↗
Biomedical subjects
M Kern
Publications and source records attributed to M Kern.
An integrative research project for teaching research concepts and nutrition principles to college students.
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Adult↗
[Arterial complications caused by using an axillary crutch].
BACKGROUND: Of all upper extremity emboli, up to twenty percent arise from an arterial, not a cardiac source. METHOD: We report about a patient with recurrent embolism, caused by an axillary crutch-induced aneurysm of the axillary artery. RESULT: After revascularisation by embolectomy and axillo-brachial vein graft bypass, the patient was free of symptoms. CONCLUSION: Angiography and duplex scanning were necessary for the correct diagnosis.
Aged↗
Possible roles for corticosterone and critical size in the fledging of nestling pied flycatchers.
Our study was designed to see whether corticosterone (B) rises abruptly in the blood of nestling pied flycatchers (Ficedula hypoleuca) at the time they fledge, as reported recently for kestrels, and if so, why. We measured the growth and blood levels of B and selected nutrients of nestlings in broods of five, seven, and nine chicks during 1998 and 1999. In half of the broods, we clipped selected wing and tail feathers of both parents with the intention of making it more difficult for them to provide their chicks with food. We collected blood samples when the chicks were six to 10 d old (period of rapid growth) and 15 d of age or older (0-5 d before fledging). B increased substantially several days before the chicks left the nest and then declined somewhat. We found no differences in rates of growth or blood levels of B, nutrients, and hematocrit as a function of either brood size or parental handicapping. Nestlings within a day of fledging appear to have been food deprived in 1998; their glucose was significantly reduced, and B, free fatty acids, and glycerol were significantly elevated compared to levels in chicks 1-4 d younger. Such changes did not occur in 1999. Blood levels of B were significantly correlated with brood size near the day of fledging, but not earlier, in both years of the study. It was possible to predict the day on which chicks would leave the nest, using their wing length when 12 d old. These results suggest that high blood levels of B associated with food restriction and sibling competition induce chicks to fledge, provided they have reached a critical size, and that the importance of fasting, sibling competition, and B may vary from year to year.
Animals↗
Selective binding of lipid A to responder and nonresponder B lymphocyte subpopulations.
125I-labeled lipid A is selectively bound to B cell-enriched populations. A combined method that employs autoradiography to detect binding of 125I-labeled lipid A and immunofluorescence to detect B cells is described. With this analytic technique it was demonstrated that 25%-30% of B cells in the spleen exhibit binding and that the binding by splenocytes from lipopolysaccharide responder mice cannot be distinguished from that of nonresponder mice.
Animals↗
Bond strength of luting cements to zirconium oxide ceramics.
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Dental Bonding↗
Stability of all-porcelain, resin-bonded fixed restorations with different designs: an in vitro study.
The strength of resin-bonded, all-ceramic fixed partial dentures with different framework and prosthesis designs was evaluated. Metal dies were fabricated from a cast of a patient missing the left central incisor and the adjacent teeth were prepared to receive an all-ceramic, resin-bonded prosthesis. Framework designs were standardized and at least 10 samples were made for testing each design. Labial veneering of the pontic with Vitadur-N significantly decreased the stability compared with that of the unveneered In-Ceram framework. Circumferential veneering of the pontic and additional proximal box preparation yielded the strongest units.
Aluminum Oxide↗
Papillary tumor of the pineal region--a new pathological entity.
Papillary tumor of the pineal region has recently been proposed as a new, distinct clinicopathological entity. On the basis of the immunophenotypic and ultrastructural properties of these lesions, origin from specialized ependymocytes of the subcommissural organ was postulated. We present the third publication on a papillary pineal tumor and describe the morphological, immunohistochemical and ultrastructural features of this neoplasm. The patient was a young woman who presented with signs of raised intracranial pressure and Parinaud syndrome. Magnetic resonance imaging revealed a neoplastic lesion in the pineal region. She underwent surgical resection of the tumor through a midline infratentorial-supracerebellar approach. Papillary tumor of the pineal region represents a new, distinct clinicopathological entity. The differential diagnosis, possible histogenesis and management of these lesions are discussed.
Adult↗
[Effect of chronic vitamin D deficiency on joint cartilage].
The effect of six-months rachitic diet on the articular cartilage of 12 white Whistar male rats has been studied using light, polarisation, and electronmicroscopes. On the basis of our observations radical changes could be noticed. The intracellular accumulation of glycogen and lipid and the necrosis of cells in the proof/inner/zone indicate the modifications of the cell's structure. The effect of permanent diet on the ground substance of articular cartilage was identified by irregular collagen fibers, and quantitative and qualitative changes of GAGs. On the basis of several author's argumentations it can be supposed that different illness/insufficiency of liver and kidney, and disturbance of resorption in human/can induce similar changes of articular cartilage which was produced by a long term rachitic diet. The cytological picture after long lasting rachitic diet is comparable with the arthrosis.
Animals↗
Marginal fit of restorations before and after cementation in vivo.
Triturated luting cements provide convenient clinical handling. This study clinically evaluated the influence of two trituration capsule cement systems on the marginal fit of inner copings for telescoping crowns. Using a randomized parallel design, one coping was cemented using zinc phosphate cement (Phosphacap) and one using a glass-ionomer cement (Ketac-Cem Maxicap) for each of 12 patients. A blind examination of the marginal fit of the restorations was made before and after cementation using the replica technique and a scanning electron microscope. The mean marginal discrepancies for all cast copings were approximately 30 microns (median 23 microns) before cementation. They increased significantly after cementation to 86 microns (median 63 microns) in the zinc phosphate cement copings but to only to 47 microns (median 44 microns) in the glass-ionomer cement copings.
Crowns↗
Effects of inorganic lead on the differentiation and growth of cortical neurons in culture.
Lead exposure has devastating effects on the developing nervous system, producing morphological, cognitive, and behavioral deficits. To elucidate some of the mechanisms of lead neurotoxicity, we have examined its effects on the differentiation of several types of cultured neurons. Previously, we reported the effects of inorganic lead on several parameters of growth and differentiation of E18 rat hippocampal neurons and two types of neuroblastoma cells cultured in medium with 2% fetal calf serum (FCS) (Audesirk et al., 1991). In the present study, we report the effects of concentrations of lead ranging from 1nM to 1 mM on the differentiation of hippocampal neurons cultured in medium containing 10% FCS. In addition, we investigated lead effects on neurons isolated from the motor cortex region of the E18 rat embryo. Cortical neurons were exposed to lead in concentrations ranging from 0.1 nM to 1 mM in medium with either 10% FCS or 2% FCS for 48 hr. The effects of lead tended to be multimodal. Neurite initiation, which is highly sensitive to neurotoxic compounds, was inhibited by lead at both high and low concentrations, with no effects at intermediate levels. Medium with 10% FCS enhanced certain growth parameters and tended to reduce the effects of lead. There was an overall consistency in the effects of lead on motor cortex and hippocampal neurons.
Animals↗