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Biomedical subjects

M Kellett

Publications and source records attributed to M Kellett.

27 records · Page 2Linked to original sources
PubMed1976

Antimetabolites produced by microorganisms. XIII. The synthesis and microbiological production of a novel amino acid, L-2-amino-4-(2-aminoethoxy) butanoic acid.

A novel amino acid, L-2-amino-4-(2-aminoethoxy-)-butanoic acid, was isolated from a fermentation broth of Streptomyces sp. X-11,085. It was shown to be identical with the chemical reduction product of an antimetabolite antibiotic, L-2-amino-4-(2-aminoethoxy)-trans-3-butenoic acid, a co-product in the fermentation. Addition of the title compound to the fermentation led to an enhanced yield of the antimetabolite suggesting that the saturated amino acid serves as a precursor for the antimetabolite.

Aminobutyrates↗
PubMed1975

Antimetabolites produced by microorganisms. XII (S)-alanyl-3-[alpha-(S)-chloro-3-(S)-hydroxy 2-oxo-3-azetidinylmethyl]-(S)-alanine, a new beta-lactam containing natural product.

(S)-Alanyl-3-[alpha-(S)-chloro-3-(S)-hydroxy-2-oxo-3-azetidinylmethyl]-(S)-alanine was isolated from a fermentation broth of an unidentified Streptomyces species 372 A. The structure was determined by single crystal X-ray diffraction analysis. The substance inhibits the growth of several strains of gram-positive and gram-negative bacteria in a chemically defined medium but growth inhibition is relieved by addition of L-glutamine to the medium.

Alanine↗
PubMedDate not supplied

The epithelial interface with osseointegrated implants.

The development of osseointegration has generated interest in the field of intraoral and maxillofacial implantology. There is well documented evidence of a high level of success in achieving osseointegration, using titanium and alumina-ceramic implant materials. Long term retention of intraoral implants appears in part, to be dependent upon the integrity of the epithelium/implant interface. This paper presents the design features of two commercially available systems Intra-Mobile-Zylinder (IMZ) and Tubingen (Frialit), which represent titanium and alumina-ceramic implants respectively, and reviews current knowledge of the nature of the epithelial junction to implant materials and the bacterial flora associated with successful and failing implants. Implant failure may be caused by a site specific infection with a similar ecosystem and bacterial flora to that found in periodontal disease. Care in patient selection and maintenance of a healthy epithelial junction are essential for the long term function of osseointegrated implants.

Aluminum Oxide↗