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Biomedical subjects

M Kedzierski

Publications and source records attributed to M Kedzierski.

13 recordsLinked to original sources
PubMed1999

CYP2D6 and GSTM1 genotypes in a Polish population.

OBJECTIVE: The aim of the present study was to investigate the distribution of the CYP2D6 and GSTM1 genotypes in a Polish population. METHODS: One hundred and forty-five unrelated healthy individuals from the western region of Poland were studied. The CYP2D6 genotype was analysed by means of polymerase chain reaction (PCR) amplification for the CYP2D6*3 and CYP2D6*4 alleles. The GSTM1 genotype was also analysed by means of a PCR assay to determine two genotypes: GSTM1-1 (positive) and GSTM1-0 (negative). RESULTS: Fourteen subjects (9.6%) were classified as poor metabolisers. The frequency of CYP2D6*4 and CYP2D6*3 was 23.1% and 2.1%, respectively. The frequency of GSTM1 nulled genotype in a Polish population came to 49%. CONCLUSION: The frequencies of poor metabolisers for CYP2D6 and GSTM1 nulled genotype among a Polish population were similar to those observed in other Caucasian populations.

Adolescent↗
PubMed1992

Avoiding tropical infections and parasitic disease.

The incidence of tropical disease among people returning from long distance journeys is increasing and nurses need to improve their knowledge of these conditions. It is more important to know where to obtain accurate and up-to-date information on tropical diseases. Travellers need advice on prophylactic measures, and this may involve altering lifestyle patterns while abroad. Nurses should be alert to the possibility of tropical or infectious diseases when patients return from abroad, and should consider measures such as barrier nursing where appropriate.

Aftercare↗
PubMed1992

Malaria--an old challenge in a modern age.

The incidence of malaria is increasing worldwide, and has reemerged in some areas where it was previously eradicated. The importance of full compliance with prophylactic medication must be stressed to travellers. Although aware of malarial symptoms, most travellers do not consult a doctor as soon as they appear. Health education about malaria represent a key area of occupational nurses' role.

Animals↗
PubMedDate not supplied

Factors determining the contamination of bone tissue procured from cadaveric and multiorgan donors.

There is an increasing demand for bone allografts that are widely used in orthopedic reconstructive procedures. The bone tissue may be harvested from two sources: cadavers and multiorgan donors. Providing safe and valuable bone allografts is of paramount importance. Contamination of allografts during bone retrieval seems to be one of the most important problems since pathogenic microorganisms might be responsible for postoperative infections and complications in the healing process. The purpose of our study was to identify all factors contributing to bacteriological contamination of harvested bones. Therefore, we have considered factors such as harvesting environment, explantation techniques, storage and preparation of allografts, number of preceding procurements from the same donor, procurement duration, and time interval between death and tissue procurement. The microbiological evaluation of allografts has been performed by taking cultures from all collected bones. Our study revealed significantly greater contamination rates of bone allografts harvested from morgue than from multiorgan donors. According to this observation, we suggest that orthopedic surgeons should pay particular attention to obtain more bones of the highest quality, personally participating in multiorgan procurements.

Bone and Bones↗
PubMedDate not supplied

Influenza: virulence and management.

In the second of her articles on influenza, Marie Kedzierski stresses that the effects of this disease are not always transient and merely uncomfortable, but can lead to chronic and debilitating physical and mental illness. It is essential, she argues, to promote rest during the acute phase of viral illness in order to minimise the risk of future complications.

Humans↗