Increase in bone magnesium content in renal failure in man.
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Biomedical subjects
Publications and source records attributed to M Kaye.
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Experience with chronic hemodialysis as a definitive form of therapy is described for six children aged 11 to 15 years at the onset. Duration on dialysis in the home has been between one and 4(1/2) years. All patients are alive and rehabilitated without serious complications. It is concluded that although transplantation is the most desirable form of treatment for children, long-term hemodialysis is an alternative acceptable second choice.
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Three cases of pericarditis with effusion associated with infection and occurring in patients under good biochemical control on hemodialysis are reported. Continuation of hemodialysis, even with regional heparinization, allowed further accumulation of fluid. Peritoneal dialysis was instituted, with subsequent improvement in all three patients. This treatment is recommended in the belief that it hastens the resolution of the condition and may obviate the necessity of establishing permanent or semi-permanent artificial pericardial drainage.
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Bone powder from patients dying with chronic renal failure of more than 1 yr duration was shown to release less calcium and more phosphate when equilibrated with a buffer solution. pH 7.4 at 4 degrees C. This change persisted after removal of the organic component and was associated with a reduction in the bone carbonate content. Crystal size and surface area showed no consistent changes from the controls and it was concluded that an alteration in the apatite crystal composition had occurred in long-standing uremia with carbonate-phosphate interchange. Support for this was provided by synthesis of apatites which were carbonate deficient and behaved in a similar manner to the uremic bones.
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