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Biomedical subjects

M Kawashima

Publications and source records attributed to M Kawashima.

At least 217 records · Page 12Linked to original sources
PubMed1992

A case of lymphadenosis benigna cutis of the earlobe: an immunohistochemical study.

We report a 38-year-old woman who developed an erythematous nodule on her earlobe after wearing pierced-type 18-carat gold earrings. Biopsy specimens revealed dense cellular infiltration predominantly composed of lymphocytes and plasma cells in the dermis and subcutaneous tissue with formation of lymph follicles. Morphological and immunohistochemical analyses were compatible with lymphadenosis benigna cutis.

Adult↗
PubMed1992

The coexistence of psoriasis vulgaris, Sjögren's syndrome, and Hashimoto's thyroiditis.

A 52-year-old woman presented with psoriasis vulgaris, Sjögren's syndrome, and Hashimoto's thyroiditis with a 5-year history. She had a number of immunological abnormalities and typical psoriatic plaques over her entire body. The relationship between psoriasis, Sjögren's syndrome, and Hashimoto's thyroiditis is discussed from the viewpoint of immunology, and similar cases in the literature are reviewed. This is the first report of a coexistence of psoriasis vulgaris, Sjögren's syndrome, and Hashimoto's thyroiditis.

Female↗
PubMed1992

A case of contact dermatitis due to methylprednisolone.

A 46-year-old woman developed contact dermatitis on her face after application of an ointment containing 0.1% methylprednisolone and 0.35% fradiomycin. Her patch test result was positive with methylprednisolone, but not with fradiomycin. No cross-reactions were observed after conducting patch tests with 17 different topical corticosteroids including prednisolone.

Dermatitis, Allergic Contact↗
PubMed1992

Epidermodysplasia verruciformis.

Epidermodysplasia verruciformis is a rare skin disease characterized by the disseminated, flat, wart-like lesions caused by human papillomavirus and a high frequency of various skin cancers. The clinical aspects, histological findings, genetic and immunological factors, and human papillomavirus types found in the disease and their roles in skin cancers are reviewed.

Epidermodysplasia Verruciformis↗
PubMed1992

Langerhans-cell histiocytosis in an adult patient with multiple myeloma.

A 44-year-old man who had suffered for 6 years from multiple myeloma developed multiple papules on the face and chest. Histological examination of these papules revealed the infiltration of predominantly histiocytic cells into the dermis and into parts of the epidermis. These cells were seen on electron-microscopic study to have Langerhans granules in the cytoplasm, which led to a diagnosis of Langerhans-cell histiocytosis concomitant with multiple myeloma. Possible explanations for this unusual association are discussed.

Adult↗
PubMed1992

Pelgeroid-like anomalous cells in the diagnosis of neutrophilic dermatosis associated with myelodysplastic syndrome.

Neutrophilic dermatoses (ND), with or without accompanying myelodysplastic syndrome (MDS), were examined in terms of nuclear abnormality like pelgeroid anomaly of infiltrating cells into skin lesions. Six ND accompanying MDS showed 1.0 to 13.5% of such anomalous cells among infiltrating cells. In contrast, ND without accompanying myeloproliferative disorders rarely had such anomalous cells. Our findings suggest that pelgeroid-like anomalous cells infiltrating into ND are probably a good marker of underlying MDS.

Aged↗
PubMed1992

Arginine vasotocin binding component in the uterus (shell gland) of the chicken.

The plasma membrane fraction of the uterus of the chicken was found to contain a component that shows specific binding to arginine vasotocin (AVT), arginine vasopressin (AVP) and oxytocin (OT). This binding component possesses a higher affinity to AVT than to AVP or OT, and the affinity to AVT was higher in laying hens than in non-laying hens and immature pullets, while the maximum number of binding sites per mg protein was less in the laying hens. Intramuscular injections of either estradiol-17 beta, progesterone or testosterone into the immature pullets for six consecutive days caused an increase in the affinity and number of binding sites. The results suggest that AVT receptors are present in the chicken uterus and that their binding properties are affected by ovarian steroid hormones.

Animals↗
PubMed1992

Enhancement of progesterone receptor bindings by estradiol in pituitary cells of the hen.

Isolated cells from pituitaries of nonlaying hens were incubated in vitro with and without estradiol-17 beta (E2), and the amount of progesterone receptor binding in the cytosolic fraction of the cells was measured by an exchange assay. When the cells were incubated with 1.0 ng E2 for 1, 2, or 4 h, the progesterone receptor bindings were increased. The bindings were not increased when incubated together with cycloheximide, actinomycin-D, or alpha-amanitin. The results suggested that the cytosolic progesterone receptor binding of pituitary cells was enhanced by the action of estrogen through a protein-synthesizing pathway.

Animals↗
PubMed1992

Luteinizing hormone-releasing hormone receptor bindings of the hen pituitary: difference between laying and nonlaying hens, effects of ovarian steroid hormones in vivo, and changes during an ovulatory cycle.

The equilibrium dissociation constant (Kd) of the pituitary luteinizing hormone-releasing hormone (LHRH) receptors and the maximum binding capacity (Bmax) per milligram of membrane protein were greater in laying hens than in nonlaying hens. A single i.m. injection of progesterone, estradiol-17 beta, or 5 alpha-dihydrotestosterone into nonlaying hens caused an increase in Kd and Bmax values. During an ovulatory cycle of the laying hen, Kd and Bmax values decreased from 16 to 14 h and 8 to 6 h before ovulation. A decrease in the Bmax value was also found 24 to 21 h before ovulation. A single i.v. injection of chicken LHRH-I caused a decrease in the Kd and Bmax values within 2 min after the injection. The results suggest that the hen pituitary LHRH receptor bindings are affected by ovarian steroid hormones and that their changes during the ovulatory cycle may relate to the release of a gonadotropin from the pituitary.

Animals↗
PubMed1992

Effect of progesterone in vitro on luteinizing hormone production in hen pituitary cells pretreated with estrogen.

Isolated cells from the pituitary gland of nonlaying hens were preincubated in vitro with or without estradiol-17 beta (E2), and then incubated with or without progesterone (P4), and luteinizing hormone (LH) in the cells and media was measured by a homologous radioimmunoassay. When the cells were preincubated with E2 for 2 h and then incubated with P4 for 4 h, cellular LH was increased, but LH in the medium remained unchanged. The increase in cellular LH in response to P4 was dose-dependent. Protein synthesis inhibitors (cycloheximide, actinomycin-D, and alpha-amanitin) blocked the response of the cells to P4. The results suggest that LH production in estrogen-primed pituitary cells of the hen was stimulated by P4 through a protein-synthesizing pathway.

Animals↗
PubMed1992

[A case of cardiac sarcoidosis associated with various clinical symptoms and thrombocytopenia].

A 29-year-old man presented with acute onset of high fever, chest pain and dyspnea. Chest X-ray film showed diffuse interstitial shadows, a cavitary lesion in the left upper lung field and cardiomegaly, but no lymphadenopathy. Abdominal CT scan showed hepatosplenomegaly and multiple small low density areas in the liver and spleen. Electrocardiogram demonstrated multifocal ventricular premature beats and ventricular tachycardia. Cardiac catheterization revealed left ventricular aneurysms. Sarcoidosis was confirmed by lung and liver biopsy. Drug therapy of prednisolone and mexiletine resulted in clinical improvement of symptoms, signs and chest X-ray film, but platelet count decreased gradually. It is suggested that an immune mechanism of sarcoidosis may have been the cause of this thrombocytopenia.

Adult↗
PubMed1992

[The sequential changes of serum acute phase reactants in response to antituberculous chemotherapy].

In order to evaluate the clinical effectiveness of response to antituberculous chemotherapy, we measured the serum levels such of acute phase reactants as C-reactive protein (CRP), alpha-1-acid glycoprotein (alpha 1-AG), haptoglobin, alpha-1-antitrypsin (alpha 1-AT) and sialic acid in 24 patients with pulmonary tuberculosis. Furthermore the relationship between these parameters and other biochemical indicators, such as serum immunoglobulins (IgG, IgA and IgM) and blood erythrocyte sedimentation rate (ESR) were observed. In the case studies of the eighteen prognostically cured patients, the serum levels of alpha 1-AG, haptoglobin, alpha 1-AT and sialic acid were significantly higher than those of healthy controls (P less than 0.01), and were significantly decreased to normal levels within three to five weeks after negative results for tubercule bacilli were obtained in the sputum cultures, while CRP, immunoglobulin and ESR showed a tendency to be lower than the healthy controls. In conclusion, alpha 1-AG, haptoglobin, alpha 1-AT and sialic acid are considered to be the sensitive biochemical indicators capable of being used to predict and monitor the clinical response to antituberculous chemotherapy.

Acute-Phase Proteins↗
PubMed1992

[A successful transatrial repair of post-infarction ventricular septal defect].

A 63-year-male underwent successful operation for the ventricular septal perforation (VSP) caused by the inferior myocardial infarction. As the condition was stable, an operation was performed at the 43rd day after onset of myocardial infarction. Exposure was obtained by the opening the right atrium and retracting the tricuspid valve. The defect was in the posterior portion of the ventricular septum and closed using a Dacron patch. His postoperative course was uneventful. Postoperative examinations show no residual shunt. We believe that this approach may offer reduced mortality and morbidity in a selected group of patients with acquired posterior VSP, by avoiding such complications as further trauma to the ventricle, hemorrhage, and arrhythmias.

Cardiac Surgical Procedures↗
PubMed1992

[Radical surgery for ovarian cancer].

Mortality rate of ovarian cancer is increasing in Japan and the management of advanced cases is an important issue in order to improve long term survival. Radical surgery including systematic lymphadenectomy (LNX) from paraaortic nodes through pelvic nodes was, therefore, performed in our department with regular surgery (TAH, BSO, omentectomy) and lymph node metastasis (LNM) was analyses. LNM rate of patients whose LNX done in the primary surgery according to pTNM classification was as follows: pT1: 9.7%, pT2: 1.1%, pT3: 66.7% and that of those LNX done at SLO was as follows: pT1: 8.3%, pT2: 0%, pT3: 69.2%. Since radical surgery improved prognosis of advanced ovarian cancer significantly radical surgery including LNX are strongly recommended as a treatment of advanced ovarian cancer.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1992

[Clinical experience with the omnicarbon valve prosthesis].

Between January 1985 and March 1990, isolated valve replacements with the Omnicarbon valve were performed in 90 patients aged 34-72 years. There were 53 aortic valve replacements (AVR) and 37 mitral valve replacements (MVR). The cumulative follow-up was 320 patient-year (py) with a mean follow-up of 3.7 +/- 1.4 years. There were 3 operative and hospital mortalities (3.3%), resulting from retrograde aortic dissection during cardiopulmonary bypass, postoperative renal failure, and rupture of infective pseudoaneurysm in ascending aorta. Seven patients died during the late postoperative period, 4 due to valve-related causes. Two of these patients died of prosthetic valve endocarditis (PVE), while the others died of thromboembolism (including valve thrombosis). The overall actuarial survival rate at 6 years was 86.3% (98.8% for AVR, and 82.1% for MVR). There were 2 thromboembolic events (one mesenteric artery thrombosis, and the other valve thrombosis). The linearized incidence of thromboembolism was 0.63%/py. PVE occurred in 3 patients (0.94%/py). One patient (0.31%/py) was found to have a valve dehiscence due to aortitis syndrome. There were no instances of anticoagulant-related hemorrhage, or valve-related hemolysis. The actuarial rate of freedom from valve-related mortality at 6 years was 93.5% (100% for AVR, and 88.1% for MVR). On the basis of a follow-up period of 6 years, good clinical results and a low incidence of valve-related complications can be demonstrated with Omnicarbon valve.

Adult↗
PubMed1992

[Percutaneous transluminal coronary angioplasty in patients with previous coronary artery bypass grafting].

Percutaneous transluminal coronary angioplasty (PTCA) has been used to treat patients with previous coronary artery bypass grafting (CABG). Seven patients with previous CABG underwent coronary artery or vein graft angioplasty following a recurrence of symptoms. Fifteen lesions were attempted in 7 patients. The primary angiographic success rate was 100%. The primary angiographic success rate was defined as reduction of a stenosis by at least 20% of the vessel diameter, leaving a stenosis of less than 60%. There were no complications following PTCA such as death or myocardial infarction. No patients were referred for urgent surgery. Three patients have undergone another PTCA after 3 months and remain well. All patients at follow-up continue to have improved symptoms. Our experience suggests that the patients with recurrence of coronary artery or bypass stenosis following CABG may be suitable for PTCA.

Aged↗