Biomedical subjects

M Kawamura

Publications and source records attributed to M Kawamura.

1,047 records · Page 59Linked to original sources

PubMedDate not supplied

Distribution of radiolabeled cis-diamminedichloroplatinum (II) on scintigraphic images in the tumor-bearing rabbit.

To evaluate the feasibility of using scintigraphic images to assess the distribution of cis-diamminedichloroplatinum (II) (CDDP), we obtained serial scintigraphic images using radiolabeled CDDP (Pt-195m CDDP), which had high specific activity (7.4 x 10(6) Bq [200 microCi]/mg-CDDP) in the rabbit VX-2 tumor system. Radioactivity at the heart decreased in a biexponential manner, with an initial half-time of 15.3 min and secondary phase of 4.5 days. Time-activity curves revealed that the tumor/heart ratio was greater than 1.0 (1.0-1.1) between 30 min and 4 hr after intravenous injection. The scintigraphic study clearly depicted the tumor. Pt-195m CDDP uptake by the rabbit tumor at 2 hr was 7.8% of the total injected dose. These data suggest that scintigraphic imaging using Pt-195m CDDP is a promising method for imaging tumors and evaluating their CDDP uptake.

Animals↗

PubMedDate not supplied

Colorectal cancer after pelvic irradiation: case reports.

Four patients with colorectal cancer after pelvic irradiation for gynaecological malignancies are reported. The interval between irradiation and the diagnosis of colorectal cancer was 15-28 years. Histological findings of radiation proctocolitis adjacent to the cancer were observed in all specimens. Ki-67 immunohistologic staining showed high cell proliferation activity in the irradiated mucosa of a recently removed specimen. Although irradiation has not been proved to induce colorectal cancer, considerable circumstantial evidence supports this belief. Awareness of this potential long-term complication is important when planing the follow-up of patients subjected to pelvic radiotherapy.

Adenocarcinoma, Mucinous↗

PubMedDate not supplied

Computed tomography of the retropancreatic peritoneal recess: a case of gastric leiomyosarcoma.

We report computed tomography of the retropancreatic peritoneal recess in a case in which gastric leiomyosarcoma developed. Because of its location behind the pancreas, an abnormal finding in the retropancreatic peritoneal recess may be radiologically mistaken for a retroperitoneal abnormality. Knowledge of anatomy of posterior peritoneal recesses and understanding of fetal development are important in the radiological diagnosis of the lesions behind the pancreas.

Diagnosis, Differential↗