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Biomedical subjects

M Kawabata

Publications and source records attributed to M Kawabata.

At least 307 records · Page 17Linked to original sources
PubMed1984

New establishment and characterization of a carcinoembryonic antigen (CEA)-producing cell line from a human carcinoma of the uterine cervix.

A new human cell line (TC-S) was established from a metastatic lesion of a inguinal lymph node of a large-cell keratinizing squamous cell carcinoma of the uterine cervix. The population doubling time was 29.8 hours. Plating efficiency was 85.5%. The mitotic coefficient was 3.2%. The generation time was about 27 hours, (G1 phase 16 hours, S phase 4 hours, G2 phase 6 hours and M phase 1 hour). Electron microscopically, desmosomes, developed tonofilaments and macronucleoli were found. After subcutaneous transplantation into nude mice, the cells grew into solid tumors that killed the mice. Histopathologically, the tumors formed in nude mice showed keratinizing squamous cell carcinoma, which resembled those of the original cervical cancer and the metastatic lymph node. The TC-S cells produced carcinoembryonic antigen (CEA). By the scanning microdensitometric and flow cytometric analyses, the TC-S was classified as hyperploid with a hyperquadroploidy mode.

Aged↗
PubMed1983

Hepatic artery embolization in 120 patients with unresectable hepatoma.

Transcatheter hepatic artery embolization was performed in 120 patients with unresectable hepatoma. The cumulative one-year survival rate was 44%. In most cases follow-up angiography revealed the selective disappearance of tumor vessels, and computed tomography demonstrated a marked decrease in tumor density without any changes in the surrounding liver parenchyma. Histologic examination in 14 cases confirmed these findings.

Adult↗
PubMed1983

Segmental obstruction of the hepatic inferior vena cava treated by transluminal angioplasty.

Five patients with segmental obstruction of the hepatic inferior vena cava associated with Budd-Chiari syndrome were successfully treated by percutaneous transluminal angioplasty using Grüntzig balloon catheters. Three or four balloons were used simultaneously to achieve sufficient dilatation. Long-term patency was obtained in all 5 cases without serious complications. This procedure may be applicable to other portions of the venous system as well.

Adult↗
PubMed1983

Circulating immune complexes and their possible relevance to other immunological parameters in Guatemalan onchocerciasis.

Circulating immune complexes (CIC) were demonstrated in sera of Guatemalan patients with onchocerciasis by Raji cell radioimmunoassay. 44% of patients but none of controls had abnormally high concentrations of CIC in their sera. The increased concentrations of CIC were found more frequently in patients with lower density of microfilariae in their skin biopsies. Patients with higher concentrations of CIC appeared to have increased titers of serum antibodies to Onchocerca volvulus. A depression of both humoral immune response to tetanus toxoid and delayed hypersensitivity reaction to PPD were found in patients with onchocerciasis. CIC may be involved in modulation of the immune response in onchocerciasis.

Adolescent↗
PubMed1982

Prevalence and incidence of onchocerciasis as baseline data for evaluation of vector control in San Vicente Pacaya, Guatemala.

The aim of this study was to estimate the incidence rate of onchocerciasis as measured by skin biopsy during field surveys carried out in San Vicente Pacaya, Guatemala from 1977 through 1979. The age standardized prevalence rates for males and females were 44.6% and 19.9%, respectively, in 1979. There were annual incidence rates of 0.08 and 0.04 for males and females, respectively. The incidence rates seem to increase with age. Since the effect of false negatives will be greater in females than in males, these rates should be interpreted cautiously. Extremely high reversion rates (proportion of negatives in a later examination among positives at the first examination by skin biopsy) were observed; these figures might be explained mainly by false negatives due to the skin biopsy. However, it is suspected that some of the apparent reversion rates may also have been influenced by other factors, e.g., sex difference.

Adolescent↗
PubMed1982

[Immunochemotherapy of resectable lung cancer--a preliminary study on a comparison of the control, levamisole, and OK-432].

We conducted a prospectively controlled study of adjuvant immunochemotherapy for resectable lung cancer in 37 cases of the control group, in 34 cases of levamisole group and in 40 cases of OK-432 group. No significant difference was noted in patient characteristics of age, sex, histological type, stage, cure rate, etc. The survival rates were calculated by Kaplan and Meier method. Survival curves were measured by generalized Wilcoxon test and Cox-Mantel test. When the levamisole group and the control group were compared in terms of survival rate, a significant increase of survival curves of patients treated with levamisole was observed in surgicopathological stage III + IV and relative curative operation groups (p less than 0.05). The survival rate of levamisole group was higher than that of OK-432 group in patients of surgicopathological stage III and III + IV (p less than 0.05). There was no statistically significant difference between OK-432 group and the control group, when in survival rates.

Adult↗
PubMed1982

Effect of traditional herbal medicine on serum testosterone levels and its induction of regular ovulation in hyperandrogenic and oligomenorrheic women (author's transl).

Eight infertile hyperandrogenic and oligomenorrheic women were investigated for lowering serum testosterone levels and inducing regular ovulation by Shakuyaku-Kanzo-To (mixed extracts of Paeonae Radix and Glycyrrhizae Radix). Serum testosterone levels (50-160 ng/dl) were lowered to less than 50 ng/dl in 7 patients by Shakuyaku-Kanzo-To 5-10 g daily administered for 2-8 weeks. Six of 7 patients ovulated regularly and 2 of 6 patients conceived. Serum LH levels, which were shown to be above 30 mIU/ml in 7 patients were lowered to less than 30 mIU/ml in 5 patients by dexamethasone 1 mg daily administered for 6.5 days. All of these patients ovulated regularly by Shakuyaku-Kanzo-To. No side effects were observed. Thus, Shakuyaku-Kanzo-To is indicated for lowering serum testosterone levels and inducing regular ovulation and pregnancy in infertile hyperandrogenic patients, especially in the patients whose serum LH levels were shown to be lowered to less than 30 mIU/ml by dexamethasone.

Adult↗