Search PubMed⌕ Search

Biomedical subjects

M Kata

Publications and source records attributed to M Kata.

At least 19 recordsLinked to original sources
PubMed1995

[Preparation and investigation of liposomes].

Vesicles dispersed in an aqueous milieu and containing a phospholipid double-layer are used primarily in cosmetic and dermatological preparations, though experiments are under way to use them as carriers of diagnostics and medicines. Different parenteral and dermatological drug preparations are already in circulation worldwide. Researchers have hopes of using them for the lyophilization of lipophobic pharmacons, to prolong medicinal effects, for the active and passive targeting of drugs etc. The first steps of liposome research started in 1965 and we now know much about liposome technology and their use in therapy, but various questions remain to be answered. On the level of basic research, this paper investigates the preparation of liposomes and characteristics influencing their stability.

Cosmetics↗
PubMed1994

[Development and investigation of preparations containing kitasamycin and flumequine].

Swine dysentery and poultry cholera are very harmful animal diseases which cause great damage. Flumequine and kitasamycin are new and up-to-date preparations for the treatment of these diseases. ++ Imequyl ad us. vet. and ++ Trubin ad us. vet. are the registered medicines. The doses are 7 mg flumequine and 21 mg kitasamycin/body weight kg. The drug technological problem is that flumequine does not dissolve sufficiently in water. It dissolves well at pH = 10, but kitasamycin is unstable at this pH. It was hoped that these two components would together act as agonists, and that kitasamycin would promote the dissolution of flumequine. An injection preparation and a powder mixture for dissolution were developed. Chemical interaction between the components was conformed by IR and NMR measurements.

Animals↗
PubMed1994

[Membrane diffusion of paracetamol].

A study was made of how different cyclodextrin (CD) derivatives, such as alpha-CD, beta-CD, gamma-CD, dimethyl-beta-CD and random-methyl-beta-CD, influence the diffusion of paracetamol. For interpretation of the phenomena, dissolution rate investigations, measurements of surface tension and determinations of partition coefficients were also performed. It was established that paracetamol has a low diffusion ability. It was also found that the different CD derivatives exert their influence in diverse ways, which depend on, among others, the cyclodextrin ratio and the mode of preparation of the product. These complementary examinations are useful for an explanation of the phenomena.

Acetaminophen↗
PubMed1993

[Formulation of diazepam suppositories, results of rheological and biopharmaceutical studies. 2. In vitro membrane diffusion and in vivo absorption results].

In the first part of the publication the rheological properties of the vehicles used for the production of suppositories were studied in order to determine the ideal parameters for formulation. In this part a detailed methodology and the results of the in vitro membrane diffusion and in vivo bioavailability studies, are presented. The results confirm a general correlation between the in vitro and the in vivo findings. It seems that hydrophilic macrogol-mixture with great molecular mass can be recommended as the optimal vehicle for formulation of diazepam suppositories.

Animals↗
PubMed1993

Conditions of cyclodextrin complexation.

In the past 20 years, cyclodextrin (CD) research has achieved considerable results, as indicated by the large number of publications and patents, the six international symposia on CDs, the new dosage forms of medicines prepared with CDs, etc. Sufficient data have accumulated to permit a survey of the most important conditions of CD complexation. Further, an account is presented of the success of precipitation of the complex involving furosemide and beta-CD.

Calorimetry, Differential Scanning↗
PubMed1990

Production and investigating of tablets containing furosemide and beta-cyclodextrin.

Furosemide is a very active drug with an excellent saluretic effect, but it dissolves in water only with difficulty. Furosemide products with beta-cyclodextrin (CD) have been made by five methods, and it has been established that most drugs are liberated most quickly from the kneaded product for the 12.72% combinations. The dissolution characteristics of furosemide are improved in tablets made from the kneaded product. By this means an essentially quicker effect can be achieved, a lower drug quantity is necessary for a similar effect, a smaller therapeutic risk in involved, and the technique is economical too.

Cyclodextrins↗