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Biomedical subjects

M Kardos

Publications and source records attributed to M Kardos.

33 records · Page 2Linked to original sources
PubMed1982

Relationship between metabolic control and plasma lipoprotein level in diabetic children.

All lipid and lipoprotein fractions except for total cholesterol were found to be high in diabetic children under long-term treatment. There was a positive correlation between HDL-cholesterol, HbA1a-c and the insulin dose. In untreated diabetic children, plasma triglyceride and its subfractions were also high, but phospholipids were normal. Total plasma cholesterol was normal, but its VLDL + LDL subfraction was increased and HDL-cholesterol low. After two months of insulin-treatment, parallel with the decrease of HbA1a-c, the HDL-cholesterol increased and there was a drop in the level of triglycerides. It is concluded that HDL-cholesterol is a good parameter of metabolic control during the initial therapy of diabetes. In patients under long-term treatment there is no such a simple relationship between control and HDL-cholesterol and the daily insulin-dose seems to play an important role in the regulation of plasma HDL-cholesterol.

Adolescent↗
PubMed1981

Effect of glucagon infusion on blood glucose, plasma immunoreactive insulin, growth hormone and adenosine 3'5'-monophosphate in obese children.

The behaviour of plasma glucose, immunoreactive insulin, growth hormone and adenosine 3',5'-monophosphate (cAMP) in response to glucagon infusion was investigated in obese and control children. Hyperinsulinaemia and low growth hormone levels were found in the obese group. Hyperinsulinaemia did not prevent the glucagon-induced cAMP release in obese children. The plasma cAMP concentration decreased after the first hour of glucagon infusion in both groups. The decline of cAMP concentration was more rapid in the obese group than in the controls, resulting in a significantly lower plasma cAMP level at the end of the glucagon load.

Child↗
PubMed1981

Fasting biochemical parameters and their relationship to anthropometric measurements in childhood obesity.

Fasting plasma immunoreactive insulin, triglyceride, free fatty acid, cholesterol, glycerol, blood glucose, lactate, pyruvate level, and lactate/pyruvate ratio were measured and an intravenous glucose tolerance test was done in obese and control children. The levels of most of the metabolites and the glucose tolerance were similar in the two groups except for the higher immunoreactive insulin and triglyceride levels in the obese group. Further metabolic alterations could be detected when the obese children were divided into subgroups on the basis of fasting insulin and triglyceride levels, and of glucose tolerance. Only three significant correlations were found between metabolic parameters and anthropometric measurements when the obese group was treated as a whole, but numerous other positive and negative correlations were detected in the subgroups. The most striking and unexpected finding was the negative correlation between cholesterol and free fatty acids and some indices of fatness in the whole obese group and in some subgroups. It is concluded that obese children ("exogenous obesity") cannot be regarded as a metabolically homogeneous group and the correlations between anthropometric parameters and plasma metabolites remain to be controversial.

Anthropometry↗
PubMed1979

Jaundice in preterm infants with hypoxia of various severity.

Maximum serum bilirubin concentration and the possible influencing factors were studied in three groups of preterm infants suffering from hyaline membrane disease. The groups were selected according to the severity of hypoxia, estimated on clinical grounds. It was found that the severity of hypoxia per se did not influence the peak bilirubin level. From among the parameters studied, only caloric intake correlated significantly and negatively with maximum bilirubin concentration in the total patient material, and more strongly in the surviving infants.

Diet↗
PubMed1979

Neonatal indirect hyperbilirubinaemia in twins.

Neonatal indirect hyperbilirubinaemia in 21 pairs of twins was compared and studied during the first postnatal week. Peak bilirubin concentration and the persistence of icterus was similar in the two sets of twins, but considerable individual inter-twin differences could be obeserved. Various postnatal parameters and inter-twin differences in these parameters were correlated with differences in hyperbilirubinaemia. It has been concluded that physiologic or idiopathic hyperbilirubinaeamia is closely similar in twins, probably due to the similar functional maturity of bilirubin clearance mechanisms. Individual variations were related to differences in caloric intake: the higher the caloric supply the lower was the maximum bilirubin concentration.

Bilirubin↗
PubMed1975

Site of action of 5-hydroxytryptophan and 5-hydroxytryptamine on the hypothalamo-pituitary-adrenal system in vitro.

5-hydroxytryptamine at a concentration of 0.04 microgram/ml was able to block the ACTH release caused by hypothalamic tissue (CRF) while it was ineffective when a hypothalamic extract containing CRF was used. 5-hydroxytryptophan added to rat adrenal tissue caused a dose-dependent increase in corticosterone production. In a dose of 0.04 microgram/ml, 0.4 microgram/ml and 4.0 microgram/ml, 5-hydroxytryptophan was able to inhibit the ACTH release caused by hypothalamic tissue in vitro. However 0.04 microgram/ml was ineffective on the increase in ACTH secretion elicited by hypothalamic extract CRF. The data suggest that the inhibitory action of 5-hydroxytryptophan and 5-hydroxytryptamine is exerted at the hypothalamic level by inhibiting the release and/or synthesis of the corticotrophic releasing factor.

5-Hydroxytryptophan↗