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M Kara

Publications and source records attributed to M Kara.

49 records · Page 3Linked to original sources
PubMed1998

The significance of amniotic fluid interleukin-6 levels in preterm labour.

This study was performed to determine the prevalence of subclinical intraamniotic infection in patients with preterm labour and intact membranes, and to evaluate the significance of interleukin-6 levels for diagnosis and prognosis of tocolysis failure, amniocentesis-delivery interval and neonatal mortality and morbidity. Transabdominal amniocentesis was performed on 74 randomly-selected patients with preterm labour and intact membranes. The prevalence of amniotic fluid infection in this group was found to be 33.7% (25 of 74). The most sensitive test to identify the intraamniotic infection was found to be the measurement of interleukin-6 level. However the most specific test was confirmed to be Gram staining. Interleukin-6 level measurement was the best test to correlate with positive amniotic fluid culture and histological chorioamnionitis. Also, interleukin-6 level measurement had the advantage of predicting preterm delivery risk and neonatal complications compared to the other tests.

Adult↗
PubMed1998

Comparison of the aerobic contributions to Wingate anaerobic tests performed with two different loads.

BACKGROUND: The purpose of the present study was to compare the aerobic contribution of the Wingate anaerobic test by increasing the test load and power output. METHODS SETTING: The study was performed in the Physiology Department of the Faculty of Medicine, Selçuk University. PARTICIPANTS: Thirty sedentary male university students volunteered to this study. EXPERIMENTS: The subjects performed two Wingate tests against resistance of 75 g.kg-1 and 95 g.kg-1 body weight on Monark 818E bicycle ergometer. Breath-by-breath oxygen consumption rates were measured using an automated metabolic measurement chart (Sensormedics 2900). Aerobic contribution was determined by dividing energy equivalence of net oxygen consumption to the total work. RESULTS: The mean total work values obtained from tests performed at 75 g.kg-1 and 95 g.kg-1 loads were 13.9 +/- 1.5 kjoules and 14.5 +/- 1.8 kjoules (t = 2.32, p = 0.03). Mean total oxygen consumptions were 765 +/- 105 ml and 770 +/- 110 ml, respectively (t = 0.24, p = 0.81). Assuming 20% mechanical efficiency for both tests, aerobic contributions were calculated as 19.5 +/- 3.7% and 18.9 +/- 3.7%, respectively (t = 1.01, p = 0.30). CONCLUSIONS: Although the power outputs of the two tests were different, the difference between aerobic contributions was not statistically significant. So, it was failed to say that the increase in the power outputs might be related to higher contribution of anaerobic processes. However, if different mechanical efficiencies could be used, relationship between aerobic contributions of two tests might have been different.

Adult↗
PubMed1996

Determination of the heart rate deflection point by the Dmax method.

OBJECTIVE: Conconi et al. proposed that the point where heart rate departed from linearity in an incremental exercise test was a good indicator of the anaerobic threshold. However, the heart rate deflection points (HRDPs) can not be determined in many subjects. The aim of this study was to determine the heart rate deflection point by the Dmax method and to compare it with the conventional linear method. SETTING: The study was performed in the Exercise Physiology Laboratory in the Faculty of Medicine, Selçuk University. PARTICIPANTS: Thirty-two untrained males (aged 18-22) performed a maximal exercise test on a cycle ergometer. RESULTS: The deflection from linearity of HR could not be detected in nine subjects (28%) by the linear method. The HRDPs could be detected in all subjects by the Dmax method. It was observed that the HR values in the HRDPs determined by both methods were close to the maximal HR values (approximately 90% of maximum). There were high correlations and no differences (p more than 0.05) between the deflection points expressed as oxygen uptake, HR and work rate determined by two methods (correlation coefficients 0.93, 0.93, 0.97, respectively, p less than 0.001). CONCLUSIONS: The Dmax method is more useful than linear method. The HRDPs of all the people can easily and objectively be found by this method.

Adolescent↗
PubMed1992

Norfloxacin interaction with antacids and minerals.

The urinary excretion of norfloxacin was measured in eight healthy volunteers after its co-administration with a variety of over-the-counter preparations, each containing a different metal ion. Commonly used doses of ferrous sulphate, zinc sulphate, aluminium hydroxide and magnesium hydroxide reduced the 24 h urinary excretion of norfloxacin by 50 to 90%. Bismuth subsalicylate had no significant effect. In vitro experiments demonstrated the formation of complexes between norfloxacin and iron, zinc, aluminium, and magnesium ions, respectively. Many pharmaceuticals contain the same metal ions that caused significant interactions with norfloxacin. The efficacy of norfloxacin treatment may be compromised when it is taken concurrently with preparations containing these metal ions.

Adult↗
PubMed1991

Clinical and chemical interactions between iron preparations and ciprofloxacin.

1. The effect of ferrous sulphate (300 mg), ferrous gluconate (600 mg), and a combination tablet of iron (10 mg), magnesium (100 mg), zinc (15 mg), calcium (162 mg), copper (2 mg), and manganese (5 mg) (Centrum Forte) co-administration on ciprofloxacin bioavailability was tested in eight healthy subjects. 2. Peak serum ciprofloxacin concentrations and area under the curve (AUC) were significantly reduced when ciprofloxacin was administered with 300 mg ferrous sulphate (3.0 vs 2.0 mg l-1, P less than 0.05 and 12.3 vs 6.7 mg l-1 h, P less than 0.01, respectively). Reductions in peak ciprofloxacin concentrations and AUC also occurred when ciprofloxacin was ingested with 600 mg ferrous gluconate (1.3 mg l-1, P less than 0.01 and 4.1 mg l-1 h, P less than 0.01, respectively) and a Centrum Forte tablet (1.4 mg l-1, P less than 0.01 and 5.4 mg l-1 h, P less than 0.01, respectively). 3. When ferrous ion was mixed with ciprofloxacin, rapid spectral changes occurred (t1/2 = 1.9 min). Additional studies were consistent with oxidation of the ferrous form of iron to its ferric form, which is followed by rapid formation of a Fe(3+)-ciprofloxacin complex. Ciprofloxacin seems to bind to ferric ion in a ratio of 3:1 by interacting with the 4-keto and 3-carboxyl groups on ciprofloxacin. 4. The formation of a ferric ion-ciprofloxacin complex is probably the cause of the reduction in ciprofloxacin bioavailability in the presence of iron.

Adult↗
PubMed1990

Sinemet-ferrous sulphate interaction in patients with Parkinson's disease.

1. This study examined the effects of administering ferrous sulphate 325 mg with Sinemet (100/25 tablet) on levodopa and carbidopa bioavailability and on signs of Parkinson's disease in nine patients. 2. Ferrous sulphate ingestion with Sinemet resulted in a decrease in levodopa area under the curve (AUC) of 30% (P less than 0.01) and a greater than 75% decrease in carbidopa AUC. Despite a strong relationship between reductions in levodopa AUC and reductions in Sinemet efficacy (r = 0.83, P less than 0.01), the average reduction in Sinemet's efficacy associated with ferrous sulphate did not achieve statistical significance (P = 0.055). 3. Chemical studies indicate that iron forms chemical complexes with carbidopa in a similar manner to levodopa and is a likely mechanism for the drug interactions. 4. AUC when a Sinemet tablet is taken concurrently with a ferrous sulphate tablet appears to be clinically significant in some but not all patients. The clinical significance of repeated ingestion of ferrous sulphate with Sinemet requires further studies.

Adult↗
PubMed1990

An early surgical approach to burns in the elderly.

This study evaluates our experience with an early surgical approach in 52 consecutive patients over the age of 65 years. Eighteen patients were taken to the operating room for early excision (less than 7 days postburn) and 34 patients were excised after 7 days (late excision). The early and late excision groups were matched for age, sex, and size of burn. In survivors, the early excision group had a 32% reduction in mean hospital stay (p less than 0.05). In addition, early surgical excision resulted in fewer episodes of sepsis and pneumonia (p less than 0.05). However, there was no significant improvement in age- and burn size-specific survival in the early excision group (p greater than 0.05). We conclude that elderly patients represent a high-risk population, and that early surgical excision results in fewer episodes of infection and a reduction in hospital stay but does not significantly improve survival.

Aged↗
PubMed1986

Triple valve procedures: an analysis of early and late results.

This study summarizes the results in 107 patients with triple valve procedures (TVP) performed between 1972 and 1983. Forty-five patients underwent double valve replacement with tricuspid annuloplasty, and 62 simultaneous triple valve replacement. The hospital mortality was 19.6% (21 patients) and was influenced by: the preoperative functional class: 4.7% (1 of 22 patients) in class II, 13.7% (7 of 51) in class III and 37.2% (13 of 35) in class IV (p less than 0.05). the urgency of operation: 13.2% in elective operations (11 of 83 patients) and 41.6% for emergencies (10 of 24) (p less than 0.02) the type of tricuspid procedure: 15.5% for annuloplasty (7 of 45 patients), 21.1% for bioprosthetic replacement (11 of 52) and 30% for mechanical valve replacement (3 of 10) (p less than 0.05). Other factors such as patient age, right ventricular systolic pressure (RVSP) and type of myocardial protection had no significant influence. The late mortality was 9% per patient-year (18 patients, 9 of whom died in the first year), the majority related to cardiac causes. The 5-year survival rate was 53%. It appears that the survival rate is higher if the patient is in preoperative functional class II (55%), the right ventricular pressure is below 60 mmHg (67%), and if the operation is performed electively (57%). The findings suggest that surgery should continue to be offered to such patients.

Adolescent↗
PubMed1981

Hemodynamic and cineangiographic study before and after mitral valvuloplasty (Carpentier's technique).

Hemodynamic studies were performed in 26 patients 2-60 months after mitral valvuloplasty (average 14 months). All patients but one had an annular deformity requiring prosthetic ring annuloplasty. In addition, 25 patients had prolapsed leaflet or restricted leaflet motion requiring specific techniques of repair. All patients were asymptomatic after operation. Significant residual mitral insufficiency was present in only five patients. Roentgenograms showed a reduction in cardiothoracic ratio, from 0.62 +/- 0.07 preoperatively to 0.53 +/- 0.06 postoperatively (p less than 0.001). Mean pulmonary artery pressure decreased from 30 +/- 12 mm Hg to 18 +/- 6 mm Hg (p less than 0.001) and cardiac index returned to normal (2.7 +/- 0.7 1/min/m2 vs 3.1 +/- 0.7 1/min/m2, p less than 0.02). Angiocardiographic studies showed that end-diastolic volume index returned to normal (148 +/- 41 cm3/m2 vs 89 +/- 23 cm3/m2, p less than 0.001), with significant decreases in end-systolic volume index ( 63 +/- 27 cm3/m2 vs 43 +/- 16 cm3/m2, p less than 0.001), left ventricular mass (114 +/- 28 g/m2 vs 88 +/- 20 g/m2, p less than 0.001), ejection fraction (58 +/- 11% vs 52 +/- 11%, p less than 0.02) and mean velocity of fiber shortening (1.19 +/- 0.36 circ/sec vs 1.01 +/- 0.24 circ/sec, p less than 0.05). We conclude that mitral valvuloplasty provides good and stable midterm results and that the operation should be performed before irreversible myocardial lesions occur.

Adolescent↗
PubMedDate not supplied

An uncommon soft tissue tumour of the chest wall: dermatofibrosarcoma protuberans.

Dermatofibrosarcoma protuberans is a slow-growing tumour with propensity for local recurrence. We report herein a case of a 36-year-old man, who presented with a huge, recurrent tumour arising from the left upper anterior part of his chest wall. We performed a wide excision with 4 cm free skin margins. Reconstruction was performed with a pedicled latissimus dorsi musculocutaneous flap and free split skin grafts. Histologic and immunohistochemical studies revealed the lesion to be dermatofibrosarcoma protuberans.

Adult↗
PubMedDate not supplied

Autoimmune polyglandular syndrome type III in monozygotic twins: a case report.

Autoimmune polyglandular syndrome is characterized by the coexistence of several autoimmune diseases, affecting predominantly the endocrine glands. Autoimmune polyglandular syndrome type III, as a subdivision of autoimmune polyglandular syndrome type II, is the co-occurrence of autoimmune thyroid disease with other autoimmune disorders without Addison disease. We present a rare case of autoimmune polyglandular syndrome type III in monozygotic twins. One of the twins also had autoimmune leukopenia. To our knowledge, leukopenia is the first mentioned coexistence in the literature of autoimmune polyglandular syndrome.

Adult↗