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Biomedical subjects

M Kamalesh

Publications and source records attributed to M Kamalesh.

23 records · Page 2Linked to original sources
PubMed1988

Anti-adrenal medullary antibodies in IDDM subjects and subjects at high risk of developing IDDM.

Previous reports have noted the presence of anti-adrenomedullary antibodies in subjects with insulin-dependent diabetes mellitus (IDDM). We initiated a study to evaluate the presence of complement-fixing anti-adrenomedullary antibodies (CF-ADM) in the following subjects: group 1 (age 4-60 yr), anti-islet cell antibody-positive (ICA+) subjects at high risk of developing diabetes, in which 9 (32%) of 28 were positive for CF-ADM; group 2 (age 6-41 yr), anti-ICA negative (ICA-) subjects at high risk of developing diabetes, in which 0 (0%) of 15 were positive for CF-ADM; group 3 (age 1-58 yr), ICA+ diabetic subjects, in which 7 (30%) of 23 were positive for CF-ADM; group 4 (age 5-68 yr), ICA- diabetic subjects, in which 1 (4%) of 24 was positive for CF-ADM; group 5 (age 20-56 yr), volunteer blood bank donor controls, in which 2 (6%) of 32 were positive for CF-ADM; and group 6, known healthy controls, in which 0 (0%) of 14 were positive for CF-ADM. CF-ADM were increased in group 1 compared with group 2 (P less than .02) and both control groups (P less than .02). CF-ADM were increased in group 3 compared with group 4 (P less than .03) and both control groups (P less than .03 vs. group 5, P less than .05 vs. group 6). Presence of CF-ADM was associated with presence of ICA in group 1 (P less than .02) and group 3 (P less than .03).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Effect of risperidone on QT interval and QT dispersion in the elderly.

Risperidone, a relatively new antipsychotic medication, is widely used in elderly adults and is reported to have fewer side effects than existing antipsychotic drugs. Recent studies, however, have reported prolongation of QT interval and corrected QT interval, both with the prescribed dose of risperidone and with overdose. Because QT dispersion measured on the surface electrocardiogram (ECG) recently has been shown to be a marker of future arrhythmic events and to predict mortality in elderly patients in a variety of clinical situations, this study was conducted to investigate the effect of risperidone on QT dispersion and corrected QT dispersion in a group of elderly patients. These patients also were evaluated for occurrence of sudden death and/or symptoms suggestive of ventricular arrhythmia. Although risperidone prolonged QT interval, it had no significant effect on QT dispersion. Further, during the follow-up period there were no incidences of sudden death or symptoms suggestive of ventricular arrhythmia. These results indicate that risperidone can be used safely in elderly patients, who are often taking several medications, without risk of increased QT dispersion.

Age Factors↗