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Biomedical subjects

M Kahle

Publications and source records attributed to M Kahle.

35 records · Page 2Linked to original sources
PubMed1984

[Enteral feeding following resection of the colon].

14 male patients with cancer of the colon were enterally fed for 2 days preoperatively, on the day of the operation and 5 days postoperatively with a high-caloric oligopeptide diet without the additional enteral administration of calories. All the anastomoses (5 rectal and 5 sigmoid colon resections as well as 4 hemicolectomies ) healed without problems; no complications occurred . The nutrition was well tolerated without exception and the jejunal tube tolerated without discomfort. The short-lived function proteins fell during postoperative metabolism. However, the means for total protein, albumin, prealbumin, transferrin and the immunoglobulins (IgM, IgG, IgA und IgD) were still within the lower part of the normal range. Only retinol-binding protein fell to values up to 30% below normal.

Blood Proteins↗
PubMed1983

[Immunoreactivity in colorectal cancer. Approaches for an immunologic diagnosis?].

An attempt was made to demonstrate a specific immunoreaction against antigens of colorectal carcinoma and its precursors in vitro. Lymphocytes of patients with colorectal carcinoma or adenoma were incubated with tumor antigens from various human carcinomas. The preparation of the tumor antigens was performed with 3 m KCl extraction from cancer tissue. The cellular immunoreactivity was measured by the electrophoretic mobility test (EMT). 51 of 57 patients with colorectal cancer had specific lymphocytic reactions to extracts isolated from colorectal cancer; 8 showed cross-reactivity to antigens from adenocarcinoma of the stomach, while there was a negative lymphocytic reaction to extracts from cancer of the breast or lung. In 10 of 15 patients with colorectal adenoma, values in the tumor range were found with extracts of colorectal carcinoma. In 16 healthy controls using identical tumor extracts, 158 measurements revealed 139 negative responses (90%).

Adenocarcinoma↗
PubMed1982

[Immune reactivity in colorectal cancer--clinical value from a surgical viewpoint].

Specificity of cellular immunity was verified by the cell migration inhibition test in 36 patients with colorectal cancer and 15 with colorectal adenomas. The electrophoretic mobility test is considered as an indirect method for demonstrating cellular immunity against malignant tumors. Soluble potassium chloride tumor extracts from various human carcinomas were used as antigens. In 31 of 36 tumor patients, a specific lymphocytic sensitization against antigens of colorectal carcinomas could be shown. Lymphocytic reactions to antigens from histologically different tumors (cross-reactions) were weaker or negative. This reaction, verified for carcinomas, was also noted in cases with precancerous lesions. Measurements in 54 healthy control persons with the same antigenic substances showed negative results in 48 cases. Acute inflammatory lesions of the colon reduce the reliability of the test.

Adenocarcinoma↗
PubMed1982

[KCl-tumor extracts in the electrophoretic mobility test [EMT]. - Clinical relevance to diagnosis of gastric cancer (author's transl)].

Using KCl-tumor extracts from various human carcinomas we tried to improve the reliability of the electrophoretic mobility test (EMT). 25 of 26 patients with histologically proven gastric cancer showed a correct positive reaction if tested with gastric cancer tumor extracts. 44 of 50 healthy controls showed negative test results when tested with the same tumor extracts. Migration inhibition in the tumor patients differed significantly from that of the healthy controls (p less than or equal to 0,05). Specificity was verified by testing gastric cancer patients with extracts from tumors of the same organ as well as different carcinomas: the most pronounced migration inhibition was observed, when gastric carcinoma extracts were used. Tumor extracts of different histogenesis showed weaker or negative reactions. Inflammatory lesions reduce the reliability of the test system: of 17 patients with ulcers or erosive gastritis 9 had false positive reactions.

Adult↗
PubMed1981

[Space occupying mediastinal processes].

About 1-2% of all tumors are found in the mediastinum. Any space-occupying swelling of the mediastinum has to be exstirpated. Even if a carcinoma cannot be completely removed, the tumor mass should be reduced as much as possible. The operation must not be delayed by any diagnostic uncertainties.

Diagnosis, Differential↗
PubMed1980

[Diseases of the ileocecal valve (author's transl)].

Diseases of the ileocecal valve are rare. Symptoms are caused by intestinal obstruction resulting from an enlargement of Bauhini's valve. The diagnosis in confirmed by x-ray. Only coloscopy and biopsy can verify the nature of the neoplasm. Regional ileocecal resection is the treatment of choice for benign lesions. In cancerous lesions hemi-colectomy has to be performed.

Humans↗
PubMed1980

[Somatostatin in small intestine fistulas].

Somatostatin (GIF) was administered to a patient with persisting intestinal fistulas. Somatostatin reduced the tryptical activity of the secretions which subsequently subsided.

Adult↗
PubMed1980

Cysts of the esophagus.

Among the pathological changes producing dysphagia, cysts are of only minor importance. Intramural pseudodiverticulosis of the esophagus as a consequence of cystic esophagitis with scarring of the submucosa and subsequent stenosis, has been observed more frequently in recent years. Congenital cysts are rarely diagnosed preoperatively. Their removal presents no technical problems. It should be remembered that esophageal cysts might be the reason for dysphagia.

Adult↗
PubMed1980

[Ileocecal mucosal prolapse].

Knowledge of normal and pathological anatomy and the radiological picture of the ileocecal valve is very important to avoid false interpretation of polyp-like findings in the cecum. Radiologically, ileal prolapse can pose as a cecal polyp. The radiological diagnosis, large 'cecal polyp' was not confirmed intraoperatively in the case presented.

Cecal Neoplasms↗
PubMed1980

[Congenital esophageal cysts].

Congenital cysts of the esophagus are rare tumors of the mediastinum. They are classified as foregut-cysts. Most of them are found accidentally on routine chest X-ray. They are seldom diagnosed preoperatively. Exstirpation of the cysts presents no major problems. Five patients with congenital esophageal cysts are presented.

Adult↗
PubMed1979

[Lipomatosis of the ileocecal valve (author's transl)].

The fatty tissue of the ileocecal valve was examined in 100 autopsies. Diffuse submucosal fatty tissue was found in a different amount among children, juveniles and adults in 93% of the cases. There was no correlation between the amount of the fatty tissue and obesity or intraabdominal adhesions. As fat deposit in the ileocecal valve already can be seen in the first years of life and as it is not depleted in malnutrition it should be considered as normal and an important factor for the structure and the function of the valve. Therefore the term lipomatosis, which refers to a pathological excess of fatty tissue, no longer should be used in connection with submucosal fat in the ileocecal valve.

Adipose Tissue↗
PubMedDate not supplied

Dupuytren's contracture.

Dupuytren's contracture is a fibroproliferative disorder of autosomal dominant inheritance that most commonly affects men over age 60 who are of Scandinavian, Irish, or eastern European descent. Local microvessel ischemia in the hand and specific platelet-derived and fibroblast growth factors act at the cellular level to promote the dense myofibroblast population and altered collagen profiles seen in affected tissue. Surgical treatment depends to some degree on patient preference and a clear understanding of the possible complications and considerable postoperative therapy commitment. Operative management is appropriate when metacarpophalangeal or proximal interphalangeal joint contracture exceeds 30 degrees. A volar zigzag Brunner incision in the digit and palm provides reliable exposure and leads to predictable healing in most cases. The mainstay of postoperative hand therapy is early active-flexion range-of-motion exercises to restore grip strength. A nighttime extension splint is often used for several months postoperatively to maintain the correction achieved in the operating room. Early recurrence of disease is most common in individuals with Dupuytren's diathesis; use of full-thickness skin grafts may be helped for these patients.

Dupuytren Contracture↗