Biomedical subjects

M Kageyama

Publications and source records attributed to M Kageyama.

129 records · Page 8Linked to original sources

PubMedDate not supplied

Assessment of treatment response in irradiated lung cancer by sequential thallium-201 SPECT: comparison with tumor volume change and survival time.

We carried out a study to evaluate treatment response and residual mass in irradiated lung cancer with single photon emission computed tomography (SPECT) using 201TI, and investigated the relation among 201TI uptake ratio, tumor volume, and patient survival time. 201TI uptake ratios and tumor volume measured before and after radiotherapy were compared in 14 patients. We divided them into a complete response (CR) group (n = 5) and partial response + no change (PR + NC) group (n = 9) according to the tumor volume response determined by CT, and a longer survival (LS) group (n = 7) and shorter survival (SS) group (n = 7) according to the survival time. The CR group showed smaller 201TI uptake ratios after irradiation (5.3 +/- 6.0%) than the PR + NC group (52.0 +/- 27.4%) (p < 0.01), but there were no significant differences in 201TI uptake ratio before irradiation or survival time in the other two groups. The LS group showed a smaller 201TI uptake ratio before (107.8 +/- 48.3%) and after (17.0 +/- 14.4%) irradiation than the SS group (126.6 +/- 34.4% p < 0.01, 52.6 +/- 27.5% p < 0.05), but there were no significant differences in tumor volume before or after irradiation in the other two groups. We concluded that 201TI SPECT is very useful to evaluate treatment response in irradiated lung cancer and can play a supplementary role in evaluating prognosis.

Adult↗

PubMedDate not supplied

Doppler spectral analysis of blood flow velocities in common femoral artery: age-related changes in healthy subjects and characteristics of abnormal hemodynamics in obstructive arterial disease.

Flow velocity patterns in the common femoral artery were analyzed in 66 lower extremities of 33 healthy subjects and 18 lower extremities of 12 patients with arteriosclerosis obliterans (ASO) by Doppler ultra-sonography. In a phantom study, Doppler flow velocity showed a close correlation with actual flow velocity: y = 1.02x - 1.22 (r = 0.995). In clinical trials, 33 healthy subjects were classified into three groups: group I (20-40 years), group II (41-60 years) and group III (61-80 years). Starting time of acceleration (STA) was shortened as age increased. Peak reverse velocity (PRV), maximum deceleration rate (MDR), and pulsatility index (PI) were significantly decreased in group III as compared with groups I and II. In patients with ASO, STA was prolonged, and PFV, PRV, MAR, MDR, PI, VSA, and FV were significantly decreased (p < 0.001) as compared with healthy control group III. Consequently, marked characteristic changes such as flattening of curves and disappearance of reverse flow in Doppler flow wave-form were observed. These data obtained by Doppler ultrasonography are thought to be useful for the early diagnosis and follow-up of patients with ASO.

Adult↗

PubMedDate not supplied

Discordant technetium-99m HMPAO and thallium-201 chloride distribution in brain tumors.

We present four cases of primary brain tumors in which both Tc-99m HMPAO and Tl-201 chloride localized in the tumors, but with discordant distribution. Larger accumulation with Tc-99m HMPAO than Tl-201 chloride was observed in two patients (one astrocytoma and one meningioma). This was related to localization of the tracer in the tumor as well as in the adjacent hyperemic region as compared with the MRI findings. In one patient with pituitary adenoma, Tc-99m HMPAO localized in nearly the entire tumor, similar to the result with Tl-201 chloride. In one patient with astrocytoma, Tc-99m HMPAO showed partial tumor accumulation, less than that shown by Tl-201 chloride. Tc-99m HMPAO uptake by brain tumors does not always reflect the viable tumor burden as compared with the distribution of Tl-201 chloride and MRI or CT findings.

Adult↗