Search PubMed⌕ Search

Biomedical subjects

M Kado

Publications and source records attributed to M Kado.

70 records · Page 4Linked to original sources
PubMed1985

[A phase II study of oral VP-16 in primary lung cancer].

A clinical trial of a new semi-synthetic podophyllotoxin, VP-16, was undertaken in patients with primary lung cancer; 56 of the 81 evaluable patients had small cell carcinoma, 9 adenocarcinoma, 8 epidermoid carcinoma, 7 large cell carcinoma, and 1 adenosquamous carcinoma. A dose of 200 mg/body/day orally for 5 consecutive days was administered every 3 to 4 weeks. Partial response (PR) was attained in 19 out of 81 (23%) and PR + MR was 35 out of 81 (43%). PR and minor response (MR) were seen as follows; small cell carcinoma, 17 PR (30%), 13 MR; epidermoid carcinoma, 2 PR (25%), 1 MR; adenocarcinoma, 1 MR; adenosquamous carcinoma, 1 MR. The dose-limiting factor was leukopenia, while thrombocytopenia was experienced in 2 cases. Clinical toxicities noted were anorexia, nausea, vomiting, stomatitis, diarrhea and alopecia, but these were well tolerated in all cases. The result indicated that VP-16 has considerable efficacy in small cell carcinoma and epidermoid carcinoma of the lung and hence its usefulness in combination chemotherapy was suggested.

Adenocarcinoma↗
PubMedDate not supplied

Comparison of the prevalence of posterior vitreous detachment in whites and Japanese.

The vitreous condition of healthy white (n = 551) and Japanese (n = 528) eyes were reviewed and compared with respect to the prevalence of posterior vitreous detachment (PVD) in the two groups. No white or Japanese patient 39 years of age or younger had PVD; the prevalence among those older than 39 increased with age in the fifth through the ninth decades, i.e., respectively, to 4%, 24%, 37% 59%, and 87% in the whites, and to 5%, 21%, 43%, 72%, and 82% in the Japanese. In none of these decades was there any significant difference between the prevalence of complete or partial PVD in the whites and the Japanese. This finding is significant because the vitreoretinal relationship influences the development and prognoses of the various vitreoretinal disorders.

Adolescent↗