Properties of gamma-aminobutyric acid receptor/ionophore proteins from crayfish muscle [proceedings].
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Aminobutyrates↗
Biomedical subjects
M K Ticku
Publications and source records attributed to M K Ticku.
Calcium and the muscarinic receptor.
Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca2+ in excitation-contraction coupling discussed.
Acetylcholine↗
Chlorpromazine metabolism. 3. Determination of conjugated metabolites in the blood of schizophrenic patients.
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Acetates↗
Chlorpromazine metabolism. II. Determination of nonconjugated metabolites in blood of schizophrenic patients.
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Chlorpromazine↗
Chlorpromazine metabolism. V. Disposition of free and conjugated metabolites in blood fractions of schizophrenic patients.
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Administration, Oral↗
Effect of anticonvulsant felbamate on GABAA receptor system.
Felbamate (FBM, 2-phenyl-1,3-propanediol dicarbamate), a potential antiepileptic drug (AED), has an unknown mechanism of action. We examined possible interaction of FBM with GABAA ergic transmission. FBM did not alter specific binding of ligands to GABA. benzodiazepine, and picrotoxin sites of the oligomeric GABAA receptor complex to rat brain membranes, nor did it enhance the effect of GABA on 36Cl-influx in well-characterized cultured spinal cord neurons. These results suggest that the anticonvulsant effect of FBM does not involve GABAA ergic transmission.
Animals↗