Search PubMed⌕ Search

Biomedical subjects

M K Mani

Publications and source records attributed to M K Mani.

At least 37 records · Page 2Linked to original sources
PubMed1982

Plasmapheresis.

Explore the source record for details and available documents.

Humans↗
PubMed1976

The economics of peritoneal dialysis: a cost-efficiency study.

To determine the maximum possible return of urea extracted per litre of peritoneal dialysis fluid used, nine test exchanges using volumes of 1, 1.5, and 2 litres of fluid for periods of 0.5, 1, and 1.5 h, were studied in 15 consecutive peritoneal dialyses. The actual quantity of urea extracted was estimated. On comparison, it was found that the best return was achieved with 1-litre volumes used for 1.5 or 1 h (80.65 +/- 5.58 and 80.18 +/- 5.13% respectively of a possible best of 100%) the difference between these being insignificant. All other exchange volumes and times used yielded significantly worse results. We recommend the use of 1-hour, 1-litre exchanges in peritoneal dialysis, except in patients who are in a hypercatabolic state, in whom we would use haemodialysis or 0.5 h 2-litre exchanges of peritoneal dialysis.

Acute Kidney Injury↗
PubMed1971

Nitroprusside revisited.

Sodium nitroprusside is a readily available, powerful hypotensive agent. It was administered intravenously in four cases when all other available hypotensive agents had failed, and blood pressure was controlled promptly and with no side effects. This is a valuable drug and deserves wider use.

Adult↗
PubMed1970

Relevance of salt, water, and renin to hypertension in chronic renal failure.

Blood pressure control was examined in 75 patients with end-stage renal failure treated by regular twice-weekly haemodialysis. Dietary sodium was restricted and extracellular fluid was removed by ultrafiltration until blood pressure was normal or signs of salt depletion were observed. Failure of these measures constituted an indication for nephrectomy. Of the 75 patients, 18 were never hypertensive, 46 had hypertension which could be corrected by salt and water depletion, and 11 had persistent hypertension which could not be controlled in this way. Nine of these 11 patients underwent bilateral nephrectomy; in each of the seven in whom the post operative result could be evaluated the blood pressure returned rapidly to normal.Plasma renin activity, measured in 34 subjects, was raised above normal in six out of nine patients whose blood pressure could not be controlled by salt and water depletion and in one of the 11 patients whose blood pressure could be so controlled, but was within the normal range in all nine normotensive patients. The mean level of plasma renin activity in the first group was significantly higher than that of each of the other two groups.There was a significant correlation between hypertension during dialysis and after transplantation, suggesting that, in addition to renin, there is a non-renal factor which predisposes certain patients to hypertension in the presence of salt and water excess.

Chronic Disease↗