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Biomedical subjects

M K Khan

Publications and source records attributed to M K Khan.

At least 37 records · Page 2Linked to original sources
PubMed1997

Cut throat injury: a retrospective study of 26 cases.

Cut throat injuries and associated deaths are common in our society. Majority succumb to their injuries. In this study, the hospital records of twenty six such cases (13 M & 13 F) were reviewed. Eleven victims were in their third decade. Eighteen cases came from poor socio-economic class. Eleven had suicidal, eleven homicidal and four accidental injuries. Familial troubles, psychiatric illness and poverty were the triggering factors in suicidal attempts. The motives of homicide included political conflict, sex related crimes, dacoity, familial, land related disputes, etc. All had their hypopharynx and/or larynx exposed. Tracheostomy was done in fifteen cases. All but two had uneventful recovery. One died in the hospital due to hemorrhage, shock and asphyxia from aspirated blood. It was observed that appropriate measures could save lives in vast majority.

Accidents↗
PubMed1991

Inpatient sociodemographic and diagnostic study from a psychiatric hospital in Libya.

Sociodemographic and diagnostic characteristics of 1009 patients admitted to the Psychiatry Hospital, Benghazi (Libya) in one calendar year are reported. Five hundred and four (50%) were 'first admission' cases. There were an average of 2.05 admissions for each 'readmission' case. Eighty nine percent of patients were of Libyan origin, of whom 62% were males; 66% were between 15-34 years of age, 37% were married, 28% were unemployed and 16% were in military service. ICD-9 schizophrenic psychosis was the commonest diagnosis (39%), followed by affective psychosis (17%), neurotic disorders (12%), organic psychosis (8%) and acute psychosis (7%). Neurotic depression was the commonest type of neurotic disorder and antisocial personality was the commonest among personality disorders. Relationship of sociodemographic variables with major diagnostic categories was studied in Libyan patients. Sociodemographic profiles of 'first admission' and 'readmission' cases of Libyan origin were also compared. These findings are discussed in relation to the sociocultural context.

Adolescent↗
PubMed1988

HLA-DR4 genotype frequency and gender effect in familial rheumatoid arthritis.

We have studied HLA-A, B, C, and DR antigens in 75 unrelated white families, each with multiple cases of adult-onset definite or classical rheumatoid arthritis (RA) (by ARA criteria). There was no difference in age of onset or serological features of RA between males and females. HLA-DR4 phenotype frequency among female (68%) and male (71%) patients also did not differ significantly. The observed frequencies of HLA-DR4 genotypes (homozygous, heterozygous, and those lacking it) differed significantly (p less than 0.005) between affected and unaffected individuals. However, the observed genotype distribution did not differ from what is expected given the Hardy-Weinburg equilibrium. There is a direct correlation between the number of DR4 allele(s) carried (two, one, or zero) and the percent affected (p less than 0.026 for females and p less than 0.052 for males). These findings highlight the importance of discerning the additional genetic determinants, including those that are gender-associated, which influence susceptibility to RA.

Arthritis, Rheumatoid↗
PubMed1986

Analysis of genetic susceptibility to familial rheumatoid arthritis.

We have studied HLA-A, B, C, and DR antigens in 37 unrelated Caucasian families with multiple cases of definite or classic rheumatoid arthritis (RA). HLA-DR4 was observed in 26 of 36 probands tested (73 per cent); and six of the 10 DR4 negative probands possessed DR1. HLA haplotype sharing among affected siblings was more often observed than would be expected if RA and HLA haplotype were segregating independently (p = 0.041). In families with a DR4-heterozygous parent, the affected parent's HLA haplotype co-segregates significantly with RA among the offspring (p less than 0.005); and in families where both parents are unaffected, occurrence of RA among the offspring co-segregates significantly with DR4 haplotype (p = 0.004). Our data strongly indicate that at least one genetic determinant for susceptibility to RA resides in the HLA region, closely linked to the DR locus, or that the susceptibility determinant may be an epitope or structure that is commonly found on DR4 molecules but occasionally on other DR molecules.

Adult↗
PubMed1986

HLA studies in familial and sporadic rheumatoid arthritis.

Fifty-eight unrelated patients with familial (36) and non-familial (22) rheumatoid arthritis (RA) have been studied for HLA-A, B, C, and DR antigens. Among the 36 probands of families with multiple cases of RA (Group I) 73 per cent are DR4 positive, and 60 per cent of the DR4 negative probands possess DR1. The corresponding frequencies among the 22 patients with non-familial (sporadic) RA (Group II) are 59 per cent and 56 per cent, respectively, DR4 and/or DR1 are present in 89 per cent of patients in Group I and 82 per cent in Group II. Homozygosity for DR4 has been definitely established by family studies in six of the 26 DR4 positive patients (23 per cent) in Group I, and a further two patients are possible homozygous. Family studies have not been performed in sporadic RA patients but two of 13 DR4 positive patients in this group are possibly homozygous for DR4. HLA haplotypes A1, Cw7, B8, DR4; and A2, Cw3, B15, DR4 are shared by two or more unrelated probands of multicase families.

Arthritis, Rheumatoid↗
PubMed1985

Selection of optimal dose.

Dose and dilution levels for quantal response bioassays and dilution assays are selected rather arbitrary. Some guidelines for designing experiments for binary data arising in such fields as bioassay studies, dilution series assays, and dose-response curves are provided. It is shown that for estimation purposes, the study should be designed in such a way so that the experimental doses lie around a critical interval. Failure to do so many produce serious bias in the Maximum Likelihood estimates. This critical interval, however, depends on the unknown parameters. With the help of extensive computer simulations for the logit model ways of overcoming this difficulty are outlined.

Biological Assay↗
PubMed1985

A controlled pore glass bead assay for the measurement of cytoplasmic and nuclear glucocorticoid receptors.

An assay for the quantitation of cytoplasmic and nuclear glucocorticoid receptors in lymphoid tissue has been developed using controlled pore glass (CPG) beads. Soluble receptor--3H-steroid complex (cytosol or nuclear extract) is adsorbed quantitatively within the crevasses of porous glass beads. Excess labeled steroid as well as most non-specifically bound steroid is easily washed away, leaving the hormone-receptor complex retained by the beads. Bound 3H-steroid is eluted with ethanol and measured for radioactivity. This procedure which is simple, rapid, and highly reproducible is carried out using frozen samples (stable for many months) containing as few as 1 X 10(7) cells. A comparison of the CPG assay to dextran coated charcoal and a whole cell assay demonstrates that CPG and dextran coated charcoal give equivalent measurements of cytosolic receptor concentration, while the CPG and whole cell assays provide equivalent values for total receptor content.

Adsorption↗
PubMed1985

Plasmacytoma of the nasopharynx (a case report with a follow-up of twelve years).

A case of plasmacytoma of the nasopharynx with a 12-year follow-up is reported. The difficulty in clinical and histological diagnosis is stressed. Despite the development of multiple metastatic lesions, repeated investigations for multiple myeloma were consistently negative. The patient was treated with a combination of radiotherapy, surgery and chemotherapy at different stages of the disease.

Follow-Up Studies↗
PubMed1984

Phyllodes tumour and stromal sarcoma of the breast: an ultrastructural comparison.

The ultrastructure of the stromal cells of three benign and one malignant phyllodes tumours and three stromal sarcomas has been studied and compared with the stromal cells of two fibroadenomas and four normal lobules. One stromal sarcoma was possibly of nerve sheath origin, but the other two showed features in common with the phyllodes tumours and the fibroadenomas. Prominent electron dense cytoplasmic bodies with distinctive morphological features are described and a correlation with the degree of malignancy is postulated.

Adenofibroma↗
PubMed1982

Peliosis of the spleen with rupture.

A case of peliosis of the spleen without apparent involvement of the liver or other organs is presented. The peliosis was discovered following rupture of the spleen after minimal trauma and was successfully treated by surgery. None of the common associations of peliosis was present (i.e., tuberculosis or intake of steroid compounds). Drugs addiction and chronic alcoholism were the only coexisting debilitating conditions exhibited by this patient.

Alcoholism↗
PubMed1982

Diagnostic value of HLA-B27 testing ankylosing spondylitis and Reiter's syndrome.

Typing for histocompatibility antigen (HLA)-B27 has been suggested as a clinically valuable diagnostic test for ankylosing spondylitis and Reiter's syndrome, although some decry its use for this purpose. Diagnoses can be made in most patients with these diseases on the basis of the history, physical examination, and roentgenographic findings. The B27 test cannot be used to screen an asymptomatic population to detect these diseases and should not be thought of as a routine diagnostic test. We present probability graphs derived from Bayes' theorem, which show that for certain patients the B27 test, when used properly, is of clinical value as an aid to diagnosis. Proper application of the B27 test in clinical medicine is discussed. The test result does not absolutely confirm or exclude the presence of these diseases; it merely provides a probability statement on their existence in the patient. The test is therefore most useful to physicians who understand the use of probability reasoning in clinical decision making.

Adult↗