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Biomedical subjects

M K Fagerhol

Publications and source records attributed to M K Fagerhol.

At least 127 records · Page 7Linked to original sources
PubMed1965

Serum prealbumin: polymorphism in man.

Serums from 390 Norwegian blood donors and 31 members of two families were studied by starch gel electrophoresis. Five different prealbumin phenotypes were found, indicating a genetic theory of three codominant alleles for which the terms Pr(F), Pr(M), and Pr(S) are proposed.

Blood Donors↗
PubMedDate not supplied

Decreased Fc-receptor binding in human monocytes exposed to ethanol in vitro.

Human blood monocytes were incubated with or without ethanol (14 mM-220 mM, initial concentration) in non-sealed wells in an atmosphere of 5% CO2 in air for various time periods. The actual ethanol concentration was assayed in the media at the beginning and at the end of each incubation period. No change in ethanol content was found after 5 or 15 min incubation, while a reduction to about 70% of the initial concentration was observed after 6 hr incubation. Binding of IgG-opsonized particles to the Fc-receptors was tested after ethanol exposure of the cells. An initial concentration of 14 or 28 mM ethanol caused no difference from controls, neither did incubation in 55 mM ethanol for 5 min. Monocyte incubated in 55 mM ethanol for 15 min showed reduced binding of particles, and further reduction was obtained by increasing the ethanol concentration. Six hr incubation in 55 mM ethanol caused no further reduction in binding capacity. Reduced binding of test particles to Fc-receptors after ethanol incubation was demonstrated with variable amounts of test particles, as well as variable length of the binding assay period. There was no change in viability, morphology or spreading ability of the monocytes after ethanol treatment.

Adult↗
PubMedDate not supplied

A strong antibody reacting with enzyme modified E positive red blood cells.

A high titer antibody was discovered in a healthy young man of blood group A1 R2r. The antibody strongly agglutinated all E positive red blood cells including his own, which had been modified by papain, ficin and bromelin, but only very weakly when modified by trypsin. The antibody was shown to be an IgM antibody. It did not react with unmodified red blood cells.

Adult↗
PubMedDate not supplied

ANCA against bactericidal/permeability-increasing protein, azurocidin, calprotectin and defensins in rheumatic and infectious diseases: prevalence and clinical associations.

OBJECTIVE: To determine the prevalence and clinical associations of ANCA against the antibiotic proteins and peptides: Bactericidal/permeability-increasing protein (BPI), Azurocidin (AZ), Calprotectin (CP) and beta-Defensin-1 and -2 (DF). METHODS: Patients with ANCA-associated vasculitides (n = 99), other vasculitides and rheumatic connective tissue diseases (n = 303), HIV-infection (n = 66), other infectious diseases (n = 134) Crohn's disease (n = 12) and ulcerative colitis (n = 12) were tested for BPI-, AZ-, CP-, DF-, PR3-, and MPO-ANCA in indirect immunofluorescence technique (IFT) and ELISA. RESULTS: In ANCA associated vasculitides BPI-ANCA were detected in 6% of patients. In HIV infection, BPI was the main target antigen of ANCA-IFT positive sera (74%). BPI-ANCA was associated with higher inflammatory activity. In Crohn's disease and ulcerative colitis BPI-ANCA was prominent (34% of patients). AZ-ANCA were found in 5% of patients. No ANCA were detected against defensin and calprotectin. CONCLUSION: BPI-ANCA is the main autoantibody in HIV and is associated with higher inflammatory activity. In inflammatory bowel diseases BPI-ANCA is predominant, AZ-ANCA are also present to a lesser extend. Both were not useful characterize clinical subgroups. No ANCA were detected against calprotectin or defensins.

Adult↗