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Biomedical subjects

M Joy

Publications and source records attributed to M Joy.

48 records · Page 3Linked to original sources
PubMed1985

Management of a case of refractory variant angina with benzhexol hydrochloride (trihexyphenidyl hydrochloride).

A patient with severe variant angina that was refractory to conventional treatment became symptom free when she was treated with benzhexol (trihexyphenidyl hydrochloride), a cholinergic blocking agent used in the management of Parkinson's disease. There was a brief psychotic reaction when a large dose was taken and some memory impairment on the maintenance dose. Benzhexol should be used with caution but may prove to be an additional therapeutic agent in the management of severe variant angina.

Adult↗
PubMed1982

Cardiology in a district hospital.

During 1975-81 a non-invasive cardiac unit was established at St Peter's Hospital, Chertsey, a district hospital serving a population of 202 000. There was a progressive increase in outpatient referrals in cardiology, and in 1981 non-invasive investigations included 424 echocardiograms, 305 exercise electrocardiograms, 275 ambulatory electrocardiograms, and 147 thallium-201 studies. Between 1979 and 1981, 151 patients were admitted directly to major centres for further investigation; 74% of those with ischaemic heart disease and 68% of those with valvular heart disease subsequently underwent surgery, a ratio of investigation to surgery that is half the norm for the four metropolitan regions. Based on the 1981 figures, which were substantially above those for 1980, there is a need for a minimum of 270 open heart operations per million of the population including 180 vein bypass operations. This figure for bypass grafting is 230% higher than in the United Kingdom as a whole in 1978 and has substantial implications.

Coronary Care Units↗
PubMed1982

Diurnal variation in exercise responses in angina pectoris.

Thirty caucasian male patients with stable angina were investigated in two groups of nine and one group of 12. Nine normal subjects were also studied. Patients in the first group (on no treatment) underwent symptom-limited exercise electrocardiography at 0800, 1200, and 1600 hours on the same day. Their heart rates and ST segment displacements at 1600 hours were significantly greater than at 0800 hours and the same phenomenon was seen in the second group who had been receiving propranolol 40 mg four times a day. A similar effect was noted for ST segment displacement but not for heart rate in the third group (on no treatment) tested at 0800 hours and 1600 hours on separate days, two to three weeks apart. Normal control subjects showed no diurnal variation in heart rate and their heart rate responses at 1600 hours were reduced by propranolol. The observations show a circadian variation in the ST segment response to exercise in patients with angina and a possible training effect on heart rate with multiple exercise testing on the same day. This variation is associated with a reduction in vagal parasympathetic tone to the heart and should be taken into account in the assessment of patients with angina and in particular when comparing responses to treatment.

Angina Pectoris↗
PubMed1981

Significance of minor ST segment and T wave changes in the resting electrocardiogram of asymptomatic subjects.

Sixteen thousand resting electrocardiograms were performed on 14000 United Kingdom professional aircrew and air traffic control officers over a two-year period; 103 asymptomatic men with minor ST segment and T wave changes at rest were assessed by exercise electrocardiography and 19 responded abnormally. Five subjects had proven coronary artery disease, one hypertrophic obstructive cardiomyopathy, and one left ventricular dilatation on echocardiography. Eleven subjects were not investigated, of whom three had strongly positive exercise responses. One subject had a false positive response and assuming a false negative response of less than 2 per cent, then a sensitivity of 80.0 per cent, a specificity of 89.1 per cent, a predictive value for the exercise electrocardiogram of 44.46 per cent and for the resting electrocardiogram of 7.8 per cent is obtained. T wave changes induced by hyperventilation were common (53.4% of all). Ten (18.2%) subjects with hyperventilation-induced T wave changes responded abnormally to exercise, three having angiographically proven coronary artery disease lending little support to the contention that the two entities rarely coexist. In spite of the low return from routine electrocardiograms in a population with a low prevalence of coronary artery disease, three-eighths of those with significant coronary artery disease presented with minor ST segment and T wave changes on their resting electrocardiograms.

Adolescent↗
PubMedDate not supplied

In vivo detection of applied electric currents by magnetic resonance imaging.

Magnetic resonance imaging is very sensitive to magnetic field variations. This inherent sensitivity can be exploited to measure small electric currents flowing in the human body. This report describes an experiment in which the magnetic fields produced by small currents applied to the forearm of a living subject have been detected in the tissue. It shows how such measurements have been used to measure current density. The suggested technique is used to measure one component of a current density in a saline solution in vitro.

Electric Conductivity↗