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Biomedical subjects

M Jones

Publications and source records attributed to M Jones.

At least 973 records · Page 54Linked to original sources
PubMed1970

Impaired glucose tolerance: a late effect of insulin shock treatment.

Glucose tolerance tests were performed in a group of patients in a mental hospital who had been treated with insulin shock and in a matched control group. Five out of 31 (16%) patients in the insulin-treated group and 1 out of 22 (5%) controls had "diabetic" blood sugar curves. Median blood sugar values were significantly higher at 60 minutes and later in the insulin-treated group, as were mean blood sugar values when the "diabetic" patients were excluded. Small amounts of plasma insulin-binding antibody were found in two insulin-treated patients. In the absence of any other clear-cut explanation, it is suggested that in some patients massive doses of insulin by injection may leave diminished tissue responsiveness to insulin as a long-term after-effect.

Adult↗
PubMed1968

The role of plasma kinin in functional vasodilatation in the pancreas.

1. Freshly collected pancreatic juice of the cat contained active kinin-forming enzyme (kallikrein) and, in addition, an active kininase.2. In response to successive doses of secretin, the kinin-forming activity of pancreatic juice fell off considerably. It was restored by pancreozymin.3. Stimulation of the dorsal vagus nerve caused an increase in venous outflow from the pancreas which was greater and more consistently seen when the splanchnic nerves had been sectioned.4. Intravenous injection of highly purified secretin usually had no effect on the outflow, whereas pancreozymin increased it up to 5 times.5. When the pancreas was perfused with oxygenated Locke solution, the effluent contained some kinin-forming enzyme when the gland was at rest. The enzyme activity did not increase when secretin was added to the perfusing fluid, but when acetylcholine or pancreozymin was added, the activity rose about fourfold.6. These results are discussed in relation to the theory that plasma kinins play a prominent role in the functional vasodilatation of glandular tissues.

Acetylcholine↗