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M Johns

Publications and source records attributed to M Johns.

67 records · Page 4Linked to original sources
PubMed1977

Cross-reactive antigens: their potential for immunization-induced immunity to Gram-negative bacteria.

The involvement of multiple species and serologic types in gram-negative bacteremia prompted evaluation of immunization with shared, cross-reactive antigens of gram negative bacilli. Active and passive immunization with Re chemotype mutants of Salmonella minnesota afforded significant protection against heterologous gram-negative bacilli and were considerably more effective than immunization with smooth S. minnesota or its Ra, Rb, Rc, Rd1 and Rd2 mutants. Since the lipopolysaccharide of the Re mutant is composed solely of 2-keto-3-deoxycotonate (KDO) and lipid A, the protective activity of antibody to the Re mutant and lipid A was evaluated. Immunization with Re mutant protected granulocytopenic rabbits against lethal bacteremia and protected mice against lethal challenge with heterologous endotoxins, whereas antibody to lipid A had no protective activity. In concomitant clinical studies, high titers of antibody to the Re mutant at the onset of bacteremia were associated with a significant diminution in the frequency of shock and death, which was independent of any effect of O-specific antibody.

Animals↗
PubMed1976

Primary squamous cell carcinoma of the parotid gland.

Primary squamous cell carcinoma of the parotid gland occurs infrequently. A retrospective study at the University of Michigan indicates an incidence of 0.3% for all parotid tumors during a 25-year period. This conforms to the data presented by other large series. Before a diagnosis of primary squamous cell carcinoma can be made, mucoepidermoid carcinomas and metastic squamous cell carcinomas must be excluded.

Aged↗
PubMed1974

Plexiglass cone.

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Equipment and Supplies↗
PubMed1973

Common enterobacterial antigen. 3. Initial titers and antibody response in bacteremia caused by gram-negative bacilli.

Antibody titers to common enterobacterial antigen (CA) were determined in 141 controls and in acute serum specimens from 206 patients with bacteremia caused by gram-negative organisms. Levels of antibody to CA ranged from 1:160 to 1:2,560 in 95% of control subjects. These levels did not differ significantly from those in acute serum specimens from bacteremic patients with "nonfatal underlying diseases." Patients with more severe underlying diseases, "ultimately fatal underlying diseases," tended to have lower titers of antibody to CA. Human antibody to CA was predominantly of the 19S variety. A fourfold change in antibody titer to CA was observed in convalescent serum obtained after bacteremia in 32% of 108 patients studied. Correlation of titers of antibody to CA in acute serum specimens with the frequency of occurrence of shock or death failed to demonstrate any protective activity of antibody to CA. These complications occurred equally as often in patients with high titers of antibody to CA as in those with low titers.

Antibody Formation↗