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Biomedical subjects

M Jan

Publications and source records attributed to M Jan.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Estrogen and progesterone hormonal receptors in meningioma. Results and comments apropos of 26 cases].

In the first part: the charcoal-assay method was briefly described (sensitivity: PR = 10 fmol/mg protein, ER = 5 fmol/mg protein), and criteria for the validity of this method were analysed: sufficient amount of tumor (150-200 mg) minimum protein concentration should be 2 mg/ml choice of a suitable labeled hormone plotting of Scatchard curve with at least 4 aligned points and systematic control of the dissociation constant (Kd) systematic assay of a reference cytosol. In the second part: the results were analysed and compared with those of various authors: PR were positive in 13 out of 23 determinations (56,5%), 12-230 fmol/mg protein (mean: 93 fmol/mg protein) ER were positive in 2 out of 25 determinations (8%), 5 and 16 fmol/mg protein. Only one tumor showed positive ER and PR and no significant difference was shown between ER and PR results on male and female patients. In conclusion, the physiopathological significance of ER and PR is discussed and a new approach to treatment of some meningiomas is mentioned.

Adolescent↗
PubMed1983

[Postarteriographic vertebral arteriovenous fistula].

The vertebral artetio-venous fistulas are seldom reported as a complication of the carotid angiography. As emphasized in this case report it's difficult to identify the place of the communication between the vein and the artery. It explains that two operations were necessary before the total exclusion of the fistula. The study of the literature recalls the main clinical features in that sort of fistula, constituted by the subjective and objective perception of a hum. The more often related complications consist in vertebro-basilar insufficiency, symptoms of root or spinal-cord squeezing, ischemic brain pathology, or cervical tumor. It's often difficult to read the angiograms because of the presence of a lot of enlarged veins. The therapy of that kind of fistula may consist in: --trapping of the fistula, but the symptoms may reappear after a few days due to the local anastomosis, --direct surgery with occlusion of the fistula which is difficult and also presents risks of recurrence (cf our case), --embolisation which looks interesting and could become the best mean of treatment in the future.

Arteriovenous Fistula↗
PubMed1982

[Meningeal hemorrhage disclosed by the initiation of Prinzmetal's angina].

The association of a cardiac disturbance and a subarachnoïd hemorrhage is well known but the cardiac signs seldom look the most important. When studying a case which was very particular because the cardiac signs consisted in a Prinzmetal's variant angina, it finality appears that the Prinzmetal's angina is not so rare as could be thought in such circumstances. Therefore a neurological pathology hidden by a cardiac one has been rarely reported such as it was seen in that case. In the literature, the influence of the parasympathetic and especially the sympathetic nervous system is emphasized as a probable cause of the most frequent cardiac abnormalities. All the authors think the medical cardiac treatment and the surgical treatment of the subarachnoïd hemorrhage have to be done at once.

Angina Pectoris, Variant↗
PubMed1981

[Selective paralysis of downward gaze with permanent conjugated upwards deviation : report of a new case (author's transl)].

Permanent upward conjugated ocular deviations are exceptional in conscious subjects : 8 cases only have been reported. They are always associated with a more or less selective paralysis of downward gaze. A further case is reported, with results of oculographic and computed tomography examinations. The latter showed a median or bilateral lesion at the diencephalo-mesencephalic junction. The mechanism provoking the deviation was clarified by studying vestibular movements which appeared abnormally ample and rapid. The authors suggest that the deviation of the eyes could result from this release of movements of vestibular origin, which can only be expressed as upwards movements because of complete paralysis of all lowering movements.

Eye Movements↗
PubMed1979

[Primary intra-cerebral hemorrhage in the new born, nursling and child (author's transl)].

The authors report 6 cases of intracerebral hemorrhages in 6 children, of what appears to be, of primary origin. 3 cases concern children between the ages of 4 and 14 years; the 3 others are situated shortly after birth or during the first months of life. A review of the literature emphasizes the sporadic nature of these cases and the persistance of diagnostic and etiological problems as to the cause of these hemorrhages. In the course of reviewing articles as well as our own personal series, it is evident that the cat scanner has demonstrated its qualifications as a diagnostic tool in the early detection of the lesions, permitting a better adapted treatment, thus improving their prognosis. The prognosis appears to be linked : --to an early diagnosis --to whether or not the hemorrhage is of massive nature or not --to the precise location of the hematoma --to the neurological state of the patient at the time of treatment --to the absence of an associated pathologie (severe prematurity, coagulation pathology). The long distance prognosis in the case of these apparently primary hemorrhages remains uncertain, due to the high rate of recidivism at a later unpredictable date (one month or several years later); to the occurence or not of a hydrocephalus especially in the case of young infants; and frequent sequels affecting superior functions. This long distance prognosis seems, however, to be little affected by the recent acquisitions in diagnostic testing.

Adolescent↗
PubMed1978

[Radicular artery thrombosis after cervical anterior approach for cervico-brachial neuralgia (author's transl)].

An anterior cervical approach completed by a bone graft is performed on a man suffering from cervico brachial neuralgia which did not improve by medical treatment and rest. During four months, the post operative course is excellent, with complete disappearance of pain and regression of the pre-existing neurological deficit. At the end of this period, the appearance of a major deficit within the field of the concerned root led to a selective brachial angiogram which revealed the existence of a radicular artery thrombosis.

Angiography↗
PubMed1975

[Mucoid pseudo-cysts of the sheath of the external popliteal sciatic nerve. Apropos of 2 cases].

Two cases of paralysis of the etxernal popliteal sciatic nerve are described. They are secondary to the development of a pseudo-cyst containing mucoid matter within the connective tissue sheath of the nerve itself. The authors describe the pathological anatomy of these lesions and discuss their aetiology, favouring the theory of mucoid degeneration of the connective tissues of the nerve sheath. They give brief indication of the clinical symptoms and emphasize the need for early but simplified surgery, ruling out any nerve resection.

Adolescent↗
PubMedDate not supplied

Measurement of voice onset time in dysarthric patients: methodological considerations.

Voice onset time (VOT) reflects the timing control between laryngeal and supralaryngeal adjustments. It has been studied both in normal speakers and patients with speech disorders, but very little information has been published on the feasibility of this measure in clinical practice. We examined 10 repeated utterances involving the voiceless stop consonants [p], [t] and [k] in 110 subjects (27 controls, 48 with spastic dysarthria and 35 with hypokinetic dysarthria). The mean rate of measurable VOT was 95% for normal speech, 80% for hypokinetic dysarthria and 84% for spastic dysarthria. The main obstacle to successful measurement was lack of the burst signifying the release of the plosive. The posterior stop [k] presented the greatest measurement difficulties for the dysarthric subjects, which is in accordance with previous perceptual reports on dysarthria.

Aged↗
PubMedDate not supplied

Rational prescription of medicines--a study of indoor patients at a tertiary care hospital.

BACKGROUND: A study was conducted at Ayub Teaching Hospital, Abbottabad, a tertiary hospital, to know whether drugs are prescribed rationally keeping in mind indications, interactions, contraindications, proper dosage and economy of the patient. METHODS: The study was a descriptive case study. Records of 200 patients admitted in various units of the hospital were analysed by a panel of pharmacologists and conclusions drawn. RESULTS: It was found that only 52% of patients receive prescriptions that were rationale in all aspects. Where as in rest of the patients the rationale could be challenged. CONCLUSION: This study stresses the need for more concentrated and dedicated effort towards prescription of medicines.

Clinical Competence↗
PubMedDate not supplied

[Spontaneous rhinorrhea due to (congenital?) evagination of arachnoidea in the paranasal sinuses].

Report on two cases of spontaneous, intermittent and long lasting spinal fluid rhinorrhea. The lesion responsible of the spinal fluid fistula is a glio-arachnoid expansion of the convexity of the frontal pole, contained into a fibrous pedicle ; it crosses the dura mater and penetrates, through a well individualized bone orifice, into the posterior wall of the frontal sinus or into an ethmoid-frontal cell. This arachnoid diverticle is not associated with an hydrocephalon. In the absence of any traumatic past history, its congenital nature may be admitted. No para-clinical investigation makes possible to detect such a minor abnormity ; the isotopic transit of the spinal fluid may remain silent, when performed at a moment of drying up of the nasal flow. Surgical exploratory study of the anterior level has to be complete, while numerous independent diverticles may coexist.

Adult↗