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Biomedical subjects

M Jaffe

Publications and source records attributed to M Jaffe.

At least 109 records · Page 6Linked to original sources

Ultrasonographic diagnosis of extremity masses.

Radiographic examination of soft tissue extremity masses is frequently inconclusive. In 18 patients with normal or nonspecifically abnormal radiographs, gray scale ultrasonography provided useful additional information. It was possible to distinguish fluid collections from solid masses, and recurrent venous thrombosis from hematoma in anticoagulated patients. Occasionally, specific diagnoses were suggested on the basis of ultrasonic morphologic characteristics. Diagnoses included soft tissue neoplasms, hematomas, aneurysms, synovial cysts, abscesses, and a lymphocele. Ultrasonically guided percutaneous needle aspiration was diagnostic to two cases. Features of differential diagnostic value relative to extremity solid masses and fluid collections are discussed. Ultrasonography is useful in evaluating these soft tissue masses.

Abscess↗

The use of the Denver Developmental Screening Test in infant welfare clinics.

The results of a single Denver Developmental Screening Test performed at the age of nine months on 823 infants attending maternal and child health centres were compared with the developmental information recorded by public health nurses during their routine well-baby care of these same infants. The single Denver test detected a significantly greater number of infants with developmental delay than did the routine observations, and the nurses tended to under-use the available resources for developmental assessment. Suggestions are made for more effective use of maternal and child health centres in the primary recognition of developmental delay.

Child Development↗

Routine analysis of dermatoglyphics and palmar creases in children with developmental disorders.

A dermatoglyphic and palmar crease analysis was carried out in 100 children aged six months to five years with psychomotor retardation (excluding Down's syndrome). When compared with 121 of the parents and a random group of 168 school-children, certain unusual features were found to be twice as common in the retarded children, demonstrating that these features may indicate an 'at risk' infant if found during routine examination of the newborn.

Child Development↗

QT dispersion in infants with apparent life-threatening events syndrome.

Apparent life-threatening event (ALTE) is a term used to define an event of unknown cause after an infant is found limp, cyanotic, bradycardic, and/or requires resuscitation. Eight to 15% of children with ALTE die of sudden infant death syndrome. Obstructive sleep apnea, bradycardia, gastroesophageal reflux, and laryngotracheal abnormalities are frequently associated with ALTE. Wide QT dispersion is associated with sudden death in heart failure and increased risk of ventricular fibrillation in acute myocardial infarction. Here, we assess QT dispersion in infants with ALTE and its correlation to clinical and electrocardiographic indices. The study included eighty nine infants (age 2.14 +/- 1.8 months, 46 males and 43 females) referred with ALTE to the pediatric emergency room and 18 controls (age 2.77 +/- 2.2 months) who underwent electrocardiogram assessment of QTmin, QTmax, QT dispersion (QT-D), and as well as QTmin, QTmax, and QT-D corrected for heart rate (QTcmin, QTcmax, QTC-D, respectively). All infants were referred at the usual diagnostic tests-the gastroesophageal reflux test, apnea monitoring, Holter ECG monitoring, electroencephalogram, and Doppler echocardiography. QT-D, QTc-D, and QTc-min were significantly greater in the ALTE group (p < 0.01). Greater QTc-D was found in males compared to females (p < 0.001). QT-D and QTc-D showed little or no correlation with age of infant or positivity of diagnostic tests. QTc has been found by multiple regression analysis to be the independent variable with the greatest impact on QTc-D (beta = -0.68, p < 0.001).

Cause of Death↗

Brucellosis: an unusual diagnosis for a seronegative patient with abscesses, osteomyelitis, and ulcerative colitis.

A 16-year-old girl developed multiple subcutaneous abscesses, osteomyelitis, and severe colitis. On the patient's second admission, a single blood culture--and, subsequently, a specimen of pus--yielded Brucella melitensis biovar 1. A second set of serologic tests, including the rose bengal test, the standard tube agglutination test, the CF test, and Coombs' test, were all negative for Brucella on the patient's second admission and 1 month later. However, a lymphocyte proliferation assay with extracted antigen of Brucella was markedly positive. Thus, this case illustrates that patients with B. melitensis infection may have a unique clinical presentation and that the lymphocyte proliferation assay is an important diagnostic tool for patients whose serologic test results are negative but for whom brucellosis is suspected.

Abscess↗

Severe visual deficits in infancy in northern Israel: an epidemiological perspective.

The characteristics of 193 legally blind children ranging in ages from birth to 4 years were analyzed. The overall incidence was 1/1000 live births; however, the ethnic specific incidence varies. All children were diagnosed before the age of 20 months and the most frequent alerting sign was lack of visual tracking. In 33.3%, the deficit was first suspected by a family member. A genetic etiology accounted for 38% of the cohort. The relative risk for an associated handicap was significant as well as the rate of hospitalizations for apparently unassociated diseases. It appears that both prevention and early detection could be achieved by a risk index.

Blindness↗