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Biomedical subjects

M Jaeger

Publications and source records attributed to M Jaeger.

At least 145 records · Page 8Linked to original sources
PubMed1975

[Proceedings: Evaluation of the hemodynamic condition during the recuperative phase after the diagnostic isoproterenol test in a patient with coronary disease].

Previous investigations concerning isoproterenol infusion (PI) in the diagnosis of myocardial ischemia have shown that ischemic ECG changes are only significant if they persist or appear after discontinuing PI. In an effort to explain the mechanisms of this delayed response, hemodynamic parameters were measured in 10 patients with angiographically proven coronary disease before, during and after PI. It was found that the principal determinants of myocardial oxygen consumption (TTI and contractility) remain significantly elevated in the recuperation phase, but that aortic pressure and systemic arterial resistance, which diminish during PI, return to pre-infusion levels immediately after halting PI. The combined effects favor the late appearance of ischemic changes in the ECG. The coronary vasodilatation with resultant increased oxygen delivery to the myocardium seen during PI may be sufficient to meet the increased myocardial oxygen demand during PI but disappears immediately if PI is discontinued.

Adult↗
PubMed1975

[Surgery of aortic valvulopathies].

75 patients were operated for isolated aortic congenital or acquired valvulopathies (46 men, 25 women and 4 children). 8 patients were reoperated because of functional defects of the artificial valve or paravalvular dehiscence. 3 children from 3 to 10 years of age underwent aortic valvular commissurotomy. The other patients had aortic valve replacement by an artificial valve. Two types of valves were used. In the beginning, we employed the Starr-Edwards valves, models 1200, 2300, 2310 and 2320. Since July 1971, we are using the Björk-Shiley valve. Less pressure gradient across the valve and less hemolysis with Björk-Shiley valve are two important factors in favoring its use. Our hospital mortality has been 5.3% and late mortality also 5.3%. Clinical improvement is observed among 80% of patients in follow-up controls.

Adolescent↗
PubMed1975

[The isoproterenol test in the electrocardiographic diagnosis of coronary insufficiency. Experience in 100 cases of ischemic cardiopathy].

Intravenous infusion of 10 to 30 gamma/min. of Isuprel for 3 to 7 minutes is accurate in diagnosing coronary disease in at least 80% of cases in our series of 100 patients with segmental coronary artery stenoses of 50% or more, demonstrated by coronary angiography. By comparing these 100 patients with a control group of 30 healthy subjects we can state that the late "ST" segment changes (persisting or appearing 3 minutes after stopping the infusion) are typical of coronary insufficiency. In patients without previous infarction, coronary insufficiency is expressed by a horizontal "ST" depression of 1 mm or more. In patients with previous infarction we observed either an "ST" depression or an "ST" elevation. The "ST" elevation, never observed in the control group, seems to have a different significance depending on whether or not a previous myocardial infarction has occurred. If there was no previous necrosis, severe coronary artery disease seems to be suggested and is a bad prognostic sign. This is not so if the patient has previously presented a myocardial infarction.

Adult↗
PubMed1975

[Development of persistent atrial paralysis secondary to acute leukemia].

The authors report a further well-documented case of long-standing atrial palsy, which they feel should be called "persistant" rather than "permanent", as "specific" treatment seems to have been responsible for its regression after about two and a half months. The case was one of atrial palsy with leukaemic infiltration of the auricles (acute leukaemia with paramyeloblasts), an aetiology without precedent in the published literature. Treatment with corticosteroids and antimitotic drugs resulted simultaneously in remission of the leukaemia and conversion to atrial fibrillation. Remission of the dysrhythmia is probably attributable to the specific treatment of the underlying pathology, which makes this case so unusual.

Atrial Fibrillation↗