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Biomedical subjects

M Jacobs

Publications and source records attributed to M Jacobs.

At least 289 records · Page 16Linked to original sources
PubMed1974

Combination Adriamycin and radiation therapy in gynecologic cancers.

Anthracyclic antibiotics, of which Adriamycin is representative, have the ability to bind to cellular DNA and thereby interfere with the X-ray repair process. When radiation survival curves of tissue cultures were studied, increased cell-killing was noted in those cultures with Adriamycin over those without the drug. The mechanism by which this occurs may be related to a reduced rate of DNA strand break rejoining, as demonstrated by use of alkaline sucrose gradient techniques. A preliminary clinical Phase I study, in which patients with advanced gynecologic malignancy were treated by simultaneous Adriamycin and X radiation, suggests that combined therapy is well-tolerated, and that such combinations may prove useful in selected patients.

Cell Survival↗
PubMed1970

A field on Che.

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Argentina↗