Radiation therapy in the management of lymph node metastases from head and neck cancers.
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Biomedical subjects
Publications and source records attributed to M J Wizenberg.
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The question of the number of radii which are necessary to accurately determine the average tissue-air ratio (TAR) to be used in 60Co rotational radiation therapy treatment planning was studied using actual patient contours. It was found that 12 radii adequately determine the average TAR for clinical purposes.
One hundred and twenty patients with early glottic carcinoma received radiation therapy at the University of Maryland Hospital from 1959 to 1977. The radiation dose ranged from 55 Gy in 4 weeks for small T1a lesions to 65 Gy in 61/2 weeks for T2 lesions. The local control rates by irradiation alone for stages T1a, T1b, and T2 were 92, 91 and 88 per cent, respectively, while 5-year determinate disease-free survival rates were 96 per cent for stage I disease and 88 per cent for stage II disease. Most of the local failures were salvaged by surgery, with a low complication rate. Regional metastases were uncommon, and occurred in 7 per cent in stage I and in 6 per cent in stage II disease. Factors increasing the risk of failures appeared to be bulky tumor, anterior commissure involvement and subglottic extension.