Biomedical subjects
M J Tobin
Publications and source records attributed to M J Tobin.
Constraints upon parenting: experience of a psychologist.
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Pre-school visually impaired children: visual stimulation and micro-computers.
A justification is offered for using micro-computers and specially-designed programs with severely visually impaired pre-school children. It is argued that this technology optimizes the visual environment for the child and provides immediate feedback about the correctness of his responses to the stimuli displayed on the screen. Some of the problems encountered in such use are described, with examples taken from sessions in which teachers are working with children as young as 2 years of age, using teaching/learning sequences designed to promote and exercise visual perception skills. Among the issues addressed are the nature of the language interactions between child and adult, the effects of altering the complexity of the tasks, and the possible value of formal task analysis as a means of enabling the teacher to pinpoint critical stages in the learning process.
186Rhenium-HNK1 monoclonal antibody targets human small cell lung cancer cells in athymic nude mice: rapid screening model for therapy.
A model is described by which in vivo tumor-MOAB interactions may be investigated. The method is rapid and may aid in the selection of appropriate MOABS from a panel of MOABS for individualized patient treatment. Groups of athymic nude mice were injected intravenously with small cell lung cancer line SHP-77 cells which are trapped primarily in the lungs. Twenty-four hours post tumor cell inoculation, 186Rhenium tagged HNK1 MOAB (CD57) was injected intravenously. Controls which received no tumor cells were injected with unbound 186Re or radioactive MOAB. Biodistribution studies at 24 hours following MOAB injection showed significantly more radioactivity in lungs of mice inoculated with both SHP-77 cells and 186Re MOAB than did lungs of controls.