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Biomedical subjects

M J Sullivan

Publications and source records attributed to M J Sullivan.

At least 163 records · Page 9Linked to original sources

Snake bite in Australia--the problems involved and a protocol for hospital management.

Despite a great deal of original research into Australian snakes and their complex venoms, there is still confusion about the correct first-aid and hospital management of the bitten patient. This review illustrates the difficulties in diagnosis and treatment and presents a well tried protocol for the successful management of snake bite.

Antivenins↗

Peripheral stimulation and human cyclofusional response.

Cyclofusional responses consisting of both motor and nonmotor components were measured during stimulation in the peripheral visual field. A 5.75 degree torsional disparity presented in 10 degrees, 30 degrees, and 50 degrees diameter visual stimulus fields induced binocular, torsional eye movements averaging 2.8 degrees to 3.4 degrees. When torsional disparity was excluded from regions up to 30 degrees diameter in the center of the visual field, binocular torsional eye movements of 3.5 degrees to 4.4 degrees were observed. A presentation of simultaneous, conflicting torsional disparities in center and annular surround regions of the stimulus field also induced torsional eye movements which reduced the disparity in only one of the two regions while increasing it in the other. The directions of eye movement changed when the surround stimulus area was enlarged at the expense of the area of the conflicting central stimulus. Based on an objective method of monitoring eye position, the findings in this report suggest that peripheral stimulation exercises a strong influence on the cyclofusional motor response component and that under suitable conditions such stimulation may have a greater influence on the cyclofusional motor response than central stimulation.

Eye Movements↗

Oropharyngeal excretion of Epstein-Barr virus by patients with lymphoproliferative disorders and by recipients of renal homografts.

In an attempt to associate oropharyngeal excretion of Epstein-Barr (EB) virus with lymphoproliferative disorders other than infectious mononucleosis, we tested throat gargles collected from adult subjects for the EB virus. Nine (16%) of 55 healthy persons were positive. High EB virus-excretion rates were found among patients with active acute lymphocytic leukemia (6/6, 100%), among renal homograft recipients during the third to 12th month after transplantation (26/30, 87%), and among critically ill patients with leukemia-lymphoma (14/19, 74%). Moderately high excretion rates were found among patients with myeloma (7/16, 44%), patients with poorly differentiated lymphocytic lymphoma (5/11, 44%), critically ill patients with solid cancers (15/37, 41%), and patients with chronic myelogenous leukemia (8/21, 38%). Our data suggested that the higher than normal excretion rate is realted to the basic disease process and to the general health status but not to the duration of cancer chemotherapy.

Antineoplastic Agents↗

A rococo report.

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Airway Resistance↗

Correlation of circulating antisperm antibodies to functional success in vasovasostomy.

The serum of 45 men with sperm in the ejaculate post-vasovasostomy was tested for antisperm antibodies. Agglutinating antibodies were found in 48 per cent of the men whose partners became pregnant and in 94 per cent of those whose partners did not become pregnant (p less than 0.01). No such correlation was found for sperm immobilizing antibodies. Spontaneous in vivo autoagglutination was not demonstrated in any of the patients. Although functional failure seems likely to be associated with an immunologic event neither sperm agglutination nor sperm immobilization seems to be the mechanism of that event.

Antibodies↗

Cadaver kidney preservation with Viacell organ perfusion apparatus.

Sixty-five kidneys (63 homografts and two autografts) underwent ex vivo preservation for periods of up to 34 hours with the Viacell renal perfusion system. Eighty percent of the homografts and both of the autografts functioned immediately. A correlation existed between poor perfusion characteristics and poor immediate function. Prolonged perfusion with this apparatus (more than 20 hours) probably had no deleterious effect on ultimate than 20 hours) probably had no deleterious effect on ultimate graft function. The machine offers portability, rapid refitting, and the ability to perfuse each kidney separately.

Cadaver↗

Thromboendarterectomy for anuria 4 1/2 years post-renal transplant: a case report.

A 45-year-old woman with a functioning renal transplant for more than 4 years presented with an acute myocardial infarction and anuria. Arteriograms demonstrated an occluded hypogastric artery. Thromboendarterectomy and instillation of fibrinolysin restored renal blood flow. Although death followed recurrent myocardial infarction 1 week postoperatively, urine output was improving and autopsy revealed viable renal tissue.

Anuria↗

Complete avulsion of the renal pedicle with survival: case reports and literature review.

Two cases of complete avulsion of the renal pedicle with survival are presented, and the nine previous cases in the available world's literature are reviewed. The young age of these patients and frequent association with trauma to other organs are discussed. Because of the common absence of hematuria, an intravenous pyelogram should be performed in all patients with significant nonpenetrating abdominal trauma, and a renal arteriogram is indicated if nonvisualization is present. A plea for immediate surgery is made, with consideration of vascular reconstruction. (See Addendum, p. 162).

Abdominal Injuries↗

Branched renal calculi.

Surgical operation on 30 kidneys was carried out for branched renal calculi, with no operative mortality. Of 23 kidneys in which conservative surgical procedures were used, 83 percent are now stone-free. When all stones were successfully removed, cultures of urine were sterile in 80 percent of cases, but when fragments remained, no patient was infection-free. It was found that impaired renal function need not be a contraindication to surgical operation, and indeed that in five of seven patients with impaired renal function, serum creatinine levels either remained stable or improved. We believe that surgical removal is the most conservative management of branched renal calculi.

Adult↗