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Biomedical subjects

M J Slooff

Publications and source records attributed to M J Slooff.

At least 145 records · Page 8Linked to original sources
PubMed1989

[Orthotopic liver transplantation in children].

Between 1-1-1982 and 1-1-1988 52 children with an end-stage liver disease were evaluated to determine whether orthotopic liver transplantation (OLT) would be appropriate. 24 children were accepted as candidates in the long term. Twelve were not accepted as potential recipients. The parents of 3 decided not to accept OLT as treatment for their children. Two children died before a suitable donor liver was available, so that OLT was carried out in 11 children. Two of these children needed a second transplant. In 3 children only a part of a donor liver was transplanted. Shortage of donor livers of small size is partly alleviated by using a part of a larger liver. The underlying diseases of the transplanted children were cryptogenic cirrhosis (1x), biliary atresia with a hepatoportoenterostomy (8x) and cirrhosis following neonatal hepatitis (2x). Ten children with OLT are clinically and physically well. Postoperatively a primary graft dysfunction occurred in one child. He was retransplanted. The median waiting time for a donor liver was 5 months. The timing for OLT has to take this in account. In treating children with end-stage liver disease (partial) OLT should be considered.

Adolescent↗
PubMed1989

[Orthotopic liver transplantation in The Netherlands 1979-1988].

In 1979 the Dutch orthotopic liver transplant programme started in Groningen. Until July 1988, 73 orthotopic liver transplantations were performed in 66 adults. A survey is given of selection criteria, indications, complications and results.

Evaluation Studies as Topic↗
PubMed1989

[Liver transplantation: patients' experiences].

The Dutch orthotopic liver transplant programme was evaluated recently. This article focuses on the physical functioning, the pattern of activities, the social functioning and the level of wellbeing of 31 transplant patients. Data were generated by means of questionnaires and interviews. The majority of the patients look upon themselves as 'healthy'. Their physical potential has greatly improved. Three-quarters of the patient group think they are able to go back to work. However, from the interviews it appears that one third of the patient group suffered from more or less serious psychological problems following transplantation.

Activities of Daily Living↗
PubMed1989

Blood concentrations after accidental cyclosporin overdose.

Two cases of children are reported with an accidental oral overdose of cyclosporin in whom blood concentrations were monitored. Despite a tenfold oral overdose, the peak blood concentrations of cyclosporin in both patients were only moderately increased above therapeutic levels. Apart from a transient rise in blood pressure in one patient, no toxic effects of cyclosporin were noticed.

Biological Availability↗
PubMed1989

Azathioprine and prednisolone immunosuppression versus maintenance triple therapy including cyclosporine for orthotopic liver transplantation. A comparative biochemical and histologic study in one center.

Improvement of graft survival after orthotopic liver transplantation is often attributed to cyclosporine. In order to assess the effects on liver function and histology, we compared the results of conventional immunosuppression (azathioprine/prednisolone = group I) and a triple drug regimen, which included CsA (group II) during the first year after transplantation. Group I consisted of 33 patients; group II of 18 patients. Significant differences are present in favor of the CsA regimen with regard to transaminases and cholestatic parameters. Liver synthesis function was slightly better, though already very good under conventional immunosuppression. One week after transplantation, normal histology was not observed in group I, while 90% of the patients showed acute rejection. In group II, 53% of the patients showed normal histology; only 40% of the patients in group II showed acute rejection (P less than 0.0002). One year after transplantation, liver histology was normal in 57% of the conventionally treated patients and in 90% of the CsA-treated patients. Also, less rejection occurred in group II during the first year after transplantation. One-year graft survival was 67% in group I and in group II 75%, which is not statistically different. Creatinine clearance did not differ in both groups. However compared with pretransplantation creatinine clearances, kidney function in the CsA-treated patients decreased with approximately 20 ml/min. These results show that liver synthesis and liver function are better under the CsA-containing triple-drug-maintenance regimen, which is supported by the far better liver histology. Kidney function is reduced, even under low dose CsA treatment.

Azathioprine↗
PubMed1989

Procurement of the liver and the whole pancreas from a single cadaver donor.

Safely harvesting the liver as well as the whole pancreas from a single donor is not yet common practice in transplantation surgery, since these organs have a partially common blood supply. Two harvesting procedures are described followed by successful transplantation of five solid organs from each donor, including liver and whole pancreas. Important details of the preferred surgical technique are the division of the hepatic artery just distal to the splenic artery and keeping the aortic patch, including superior mesenteric artery and coeliac trunk with the pancreas graft. Using this technique the liver and the whole pancreas could be transplanted without extra vascular anastomoses, while vascular grafts were not necessary. The risk of thrombosis during pancreas and liver transplantation is minimized in this way, while the primary function of each of the five harvested organs was excellent.

Cadaver↗
PubMed1989

Successful pregnancy after orthotopic liver transplantation.

A successful pregnancy occurred in the first year after liver transplantation. The patient was treated with prednisolone, azathioprine, and low-dose cyclosporine A. A healthy girl of 2260 g (fifth to tenth percentile) was born at 38 weeks.

Adult↗