Search PubMedSearch

Biomedical subjects

M J Sedler

Publications and source records attributed to M J Sedler.

8 recordsLinked to original sources

Understanding delusions.

Delusions traditionally have been considered as fixed, false beliefs, born of morbidity. Whereas this definition serves to orient the clinician to the phenomena at hand, each element breaks down under scrutiny. It has been shown that delusions are not necessarily false, although in some sense they are discordant with reality. When delusions coincide with actual events their judgements can be shown to be independent of this evidential basis; when they refer to disorders of experience, such as first rank symptoms, the experience usually contains a distorted meaning. The supposition that delusions are a variety of belief has itself been questioned. On the one hand, they do not always refer in a meaningful way to anything, or when they do they fail to function as evaluative judgments; instead, delusions are experienced subjectively in ways that are characteristic of knowing rather than believing. On the other hand, delusions are not ascertained clinically by surveying the patient's belief system; rather their failure to achieve the status of objective knowledge leads to the post hoc relegation of delusions to the epistemologic waste basket of beliefs. To treat delusions as necessarily the product of morbidity is essentially tautologous insofar as delusions are, by definition, pathologic; that is, as defective judgments delusions are not simply erroneous, they are disordered. Finally, the fixity of delusions is an empirical matter and varies widely. Underlying this perceived intractability, however, are the subjective certainty and incorrigibility that Jaspers identified and which Spitzer has recast in the form of "epistemological asymmetry" misapplied to external reality. Although delusions typically have been recognized and categorized according to their manifest content, these formal considerations are crucial to understanding the nature of delusions.

Delusions

Foundations of the new nosology.

DSM-III and its revisions have provided little in the way of explicit historical or philosophical foundations. The logical empiricism embedded in its operational criteria and its external approach to validation are inadequate to account for the presumption of nosological regularities or the specific categories endorsed by the taxonomy. The nosologic operation that Jaspers referred to as the "synthesis of disease entities" is explored in connection with the central distinction in DSM-IV between mood disorders and schizophrenic disorders. This synthetic operation is analyzed in terms of the paradigmatic shift from the mania-melancholia matrix of pre-modern psychiatry to the manic-depression/dementia praecox model defined by the work of Kraepelin. In the context of this analysis the self-evidence of these regularities is questioned.

Bipolar Disorder

Aprosodia in eight schizophrenic patients.

Research interest in the "negative" symptoms of schizophrenia has increased in recent years. Given the clinical similarity between affective deficits in schizophrenic patients and aprosodic deficits in stroke victims, the authors conducted a study testing for aprosodia in eight schizophrenic patients. Seven were found to have aprosodia with motor components. Further study of the aprosodias may provide some insight into affective disturbance in schizophrenia.

Adult

The legacy of Ewald Hecker: a new translation of "Die Hebephrenie". Translated by Marie-Louise Schoelly.

Early descriptions of schizophrenia may be found in the writings of Haslam and Morel, but the turning point in the development of the modern concept was Ewald Hecker's classic paper on hebephrenia in 1871. The syndrome he described--a psychosis of early onset with a deteriorating course characterized by a "silly" affect, behavioral peculiarities, and formal thought disorder--not only adumbrated Kraepelin's generic category of dementia praecox but quite specifically defined the later subtype of hebephrenic, or disorganized, schizophrenia as well. The present translation into English of Hecker's "Die Hebephrenie" makes accessible a crucial milestone in the history of modern psychiatry.

Germany

Falret's discovery: the origin of the concept of bipolar affective illness. Translated by M. J. Sedler and Eric C. Dessain.

Jean Pierre Falret's once celebrated but now neglected 1854 description of "circular insanity" has not been translated into English until now. This seminal essay clearly articulated for the first time the rudimentary elements of our present diagnosis of bipolar affective disorder. It contains lucid descriptions of manic excitement and depression and the "switch" from one to the other; moreover, it emphasizes the importance of course and prognosis, as well as hereditary and epidemiologic factors. Although American psychiatry instinctively looks to the German literature for its foundations in Kraepelin, Bleuler, and Freud, the translation of Falret's essay represents an effort to trace contemporary psychiatric concepts to their origins in nineteenth-century France.

Bipolar Disorder

Freud's concept of working through.

Of all Freud's concepts, working through most completely characterizes the role of the patient in analysis. Conceived as the labor of the patient, rather than as an analytic technique, working through consists of two phases: recognizing resistances (insight) and overcoming resistances (change). In this paper these achievements are explicated in terms of the collaborative, yet conflicting, functions of remembering and repeating. A metapsychological consideration of the resistances in question leads to the system of concepts defined by id-resistance, the compulsion to repeat, and the death instinct. Finally, the concept of working through gives evidence for the idea of a will to recovery which, in the psychoanalytic situation, becomes a will to remember.

Association