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Biomedical subjects

M J Rowe

Publications and source records attributed to M J Rowe.

At least 91 records · Page 5Linked to original sources
PubMed1976

The effect of antilipolytic agents on cyclic AMP, free fatty acid and total catecholamine concentrations in plasma.

Plasma concentrations of adenosine 3':5' cyclic monophosphate (cyclic AMP) and free fatty acids have been measured in 15 patients with acute myocardial infarction and in 6 dogs given infusions of isoprenaline. Plasma total catecholamines were also estimated in the patients. Inhibition of adipose tissue lipolysis with a nicotinic acid analogue did not decrease plasma cyclic AMP concentrations, either in the patients or when elevated in the dogs, thus suggesting that this tissue is not a major source of the nucleotide in plasma.

Acute Disease↗
PubMed1975

Control of ventricular arrhythmias during myocardial infarction by antilipolytic treatment using a nicotinic-acid analogue.

The effect of lowering raised plasma-free-fatty acids (F.F.A.) on the incidence of serious ventricular arrhythmias after myocardial infarction was assessed by a double-blind trial in eighty-one patients. A nicotinic-acid analogue (N.A.A.) with very slight haemodynamic effects was given within 12 hours of the onset of myocardial infarction to lower plasma-F.F.A. When treatment with N.A.A. was started within 5 hours of the onset of symptoms, the numbers of patients with ventricular symptoms, the numbers of patients with ventricular tachycardia were significantly reduced, provided elevated plasma-F.F.A. levels were rapidly lowered and maintained in the normal range throughout the treatment period. The incidence of R-on-apex T ventricular premature beats and beats in which the ectopic R wave interrupted the apex of the T wave of a previous ventricular premature beat was also reduced in patients receiving N.A.A within 5 hours of the onset of symptoms. Plasma-total-catecholamines and serum-creatine-kinase levels were similar in the N.A.A.-treated and placebo groups. N.A.A. rarely caused skin flushing, but vomiting occurred in some patients after many hours of treatment. These findings suggest that treatment directed towards stabilsing the matabolism of the ischaemic myocardium can be of therapeutic value and lead to fewer serious ventricular arrhythmias.

Arrhythmias, Cardiac↗
PubMed1973

Cutaneous convergence on to the climbing fibre input to cerebellar Purkynĕ cells.

1. In cats anaesthetized with Nembutal, the cutaneous receptive fields of individual cerebellar climbing fibres were assessed by recording the climbing fibre responses of single Purkyne cells following controlled mechanical stimulation (air jets, vibration, taps, pressure) of the foot pads of all four limbs and of the hairy skin of the limbs and the body.2. Three major types of cutaneous receptive fields of individual climbing fibres were recognized: (a) restricted fields generally confined to the distal areas of one limb only; (b) circumscribed fields on the distal areas of two to four limbs (discontinuous fields); and (c) widespread continuous fields extending over all or almost all of the body surface. A fourth group appears to receive cutaneous inputs from one limb and sensory input from deeper structures in other limbs.3. Thresholds for tapping of the foot pads were often quite low (< 100 mum indentation), and there was no noticeable difference in the distribution of thresholds between the climbing fibres having restricted or more widespread cutaneous receptive fields. Similarly, the latencies of climbing fibre responses evoked by vibration and tapping were in the same ranges for climbing fibres with receptive fields restricted to one limb only and for those having more widespread fields.4. In regard to location in the anterior lobe of the cerebellum it was found that those climbing fibres receiving inputs only from the ipsilateral forelimb projected to Purkyne cells located almost entirely in lobule V, whereas all other climbing fibres with restricted or more widespread receptive fields projected to Purkyne cells distributed widely within lobules II to V.

Air↗
PubMed1973

Cortical and peripheral modification of cerebellar climbing fibre activity arising from cutaneous mechanoreceptors.

1. In cats anaesthetized with Nembutal climbing fibre (CF) responses evoked in individual cerebellar Purkyne cells by mechanical stimulation of the skin were conditioned by preceding stimuli both to the periphery and to the precruciate area of the cerebral cortex.2. Cortical stimulation, generally subthreshold for evoking a CF response itself, induced an inhibition of cutaneous evoked CF responses in 65% of all Purkyne cells tested. The maximum inhibition ranged from 40 to 100% of the control responses at conditioning-testing intervals of 30-70 msec and the duration of the inhibition was usually 125 msec.3. In most cases the corticofugal inhibition of cutaneously evoked CF responses was mediated by inhibitory mechanisms outside the cerebellar cortex, probably at relays within the spino-olivocerebellar pathways. Purkyne cells undergoing corticofugal inhibition were distributed widely within both the vermis and the pars intermedia of the anterior lobe.4. In 40% of all Purkyne cells tested, there was evidence for afferent inhibition of their peripherally evoked CF responses as revealed by conditioning stimuli applied to the skin outside the receptive field. Again it was found that the inhibition was exerted at levels prior to the cerebellum.5. It is concluded that the afferent input transmitted to Purkyne cells via climbing fibres can be modified by corticofugal and peripheral influences exerted on the relays of the CF pathways outside the cerebellar cortex.

Anesthesia, General↗