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Biomedical subjects

M J Noble

Publications and source records attributed to M J Noble.

43 records · Page 3Linked to original sources

Renal subcapsular hematoma: a diagnostic and therapeutic dilemma.

Subcapsular renal hematomas have been found in 14 hypertensive patients between 17 and 66 years old. In 11 patients with chronic lesions hypertension improved more often with nephrectomy (7 of 7 cases) than with a conservative operation (2 of 4 cases). Non-operative management of acute hematoma resulted in radiographic resolution and improvement of hypertension in 3 of 3 patients. Awareness of the clinical features and judicious use of diagnostic modalities enable proper management of subcapsular renal hematomas in most cases.

Adolescent↗

Screening excretory urography in patients with cryptorchidism or hypospadias: a survey and review of the literature.

Hypospadias and cryptorchidism constitute common problems in urology for which the use of routine screening urography has been challenged recently. To assess better current thinking 233 urologists who devote a significant part of their practice to children were surveyed as to the number of procedures performed as well as to the instances when excretory urography was obtained. Of 163 physicians who responded 70 per cent do not favor routine screening urography in cryptorchid patients, while approximately 50 per cent believe that it is worthwhile in hypospadias. In the cryptorchid responses there was a definite decrease in the percentage of physicians obtaining x-rays as the yearly volume of cases increased (50 per cent with less than 10 cases per year and 18 per cent with greater than 20 cases per year), while this relationship was not maintained for hypospadias. A review of the literature correlates well with this survey in that excretory urography is not necessary in cases of cryptorchidism but its value is still debated in cases of hypospadias.

Cryptorchidism↗

Preservation of ischemically damaged canine kidneys. Cold storage versus perfusion.

Dog kidneys subjected to a period of warm ischemia followed by either simple cold storage or hypothermic pulsatile perfusion were autotransplanted 24 hr after harvesting, and a contralateral nephrectomy was performed at the same time. Renal function was comparable with both techniques, and all dogs survived. When kidneys were subjected to 30 min of warm ischemia followed by one of the two preservation methods, renal function was again comparable and 50 per cent of the animals in each group survived. We conclude, therefore, that for 24 hr of canine renal preservation, cold storage is as effective as pulsatile perfusion even when the kidney has been initially subjected to 30 min of warm ischemia.

Animals↗

Aortorenal reimplantation in treatment of renovascular hypertension.

From 1964 to 1977, 33 patients underwent aortorenal reimplantation as surgical treatment for renovascular hypertension. Over-all results were 13 patients cured (39 per cent), 15 patients improved (46 per cent), and there were 5 failures (15 per cent). The results were equally satisfactory in patients with atherosclerotic or fibrous renal artery disease. Postoperative arterial stenosis or occlusion occurred in 5 patients (15 per cent). Aortorenal reimplantation is an effective method of renal revascularization in properly selected patients, and long-term results are comparable with those of aortorenal bypass.

Adolescent↗

A portable smoking pattern recorder.

An instrument has been developed which can be used to record the smoking patterns of human smokers in almost any location. The smoker is required to smoke the cigarette through an orifice plate cigarette holder connected to the recorder. The smoking pattern data are recorded onto a standard audio cassette as pressure and flow signals together with timing impulses and speech. The instrument is battery powered and can be built into a small brief case. The four channels of data are decoded on a separate instrument, which uses the timing signals to synchronise a data logger, thus making the whole system independent of tape speed errors. The speech channel is used to identify the smoker, cigarette, location, etc. Comparisons have been made of the performance of the portable recorder and a laboratory smoking analyser and data logger. It was found that data decoded from the portable recorder are generally within 1% of the values recorded directly on the laboratory instrument.

Computers↗