ANALGESIC PROPERTIES OF SUB-ANAESTHETIC DOSES OF FLUORINATED ANAESTHETICS IN THE MOUSE.
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Analgesics↗
Biomedical subjects
M J NEAL
Publications and source records attributed to M J NEAL.
THE HYPERALGESIC ACTION OF BARBITURATES IN MICE.
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Anesthesia↗
THE MEASUREMENT OF ANALGESIC PROPERTIES OF INHALATION DRUGS GIVEN IN SUB-ANAESTHETIC CONCENTRATIONS.
An electrical method of testing for analgesia in mice has been developed for use with inhalation anaesthetics given in sub-anaesthetic concentrations. The anaesthetic drugs are administered in a gas chamber designed for the testing of analgesia without removal of the animals from the chamber.
Analgesia↗
THE ANALGESIC PROPERTIES OF SUB-ANAESTHETIC DOSES OF ANAESTHETICS IN THE MOUSE.
Trichlorethylene in a sub-anaesthetic concentration (0.5% v/v in oxygen) has an analgesic effect on mice, which develops slowly and reaches a maximum roughly equivalent to that produced by 5 mg/kg of methadone hydrochloride given by intraperitoneal injection. Ethyl chloride causes analgesia in sub-anaesthetic concentrations (3%) but is much less potent than trichlorethylene. Halothane (0.75%) produces slight but definite analgesia. Cyclopropane and diethyl ether have no appreciable analgesic effect. Concentrations of nitrous oxide (up to 90%) in oxygen lack any observable analgesic action on the mouse. Trichlorethylene is considerably potentiated by nitrous oxide, its anaesthetic rather than its analgesic action being affected. Nitrous oxide (40%) potentiates the analgesic rather than the anaesthetic action of halothane (0.75%). However, increasing the concentration of nitrous oxide to 60% causes the anaesthetic action of halothane to predominate.
Analgesia↗