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Biomedical subjects

M J Morgan

Publications and source records attributed to M J Morgan.

At least 181 records · Page 10Linked to original sources
PubMed1980

The regulation of carbohydrate metabolism in animal cells: isolation of a glycolytic variant of Chinese hamster ovary cells.

A variant of Chinese hamster ovary cells is described which is deficient in two glycolytic enzymes: glucosephosphate isomerase and phosphoglycerate kinase. The variant grows readily on glucose, but in contrast to the parental cell it does not excrete lactic acid. The impaired ability of the variant to perform aerobic glycolysis both in vivo and in vitro is correlated with the deficiency in both glycolytic enzymes.

Anemia, Hemolytic, Congenital Nonspherocytic↗
PubMed1980

Spatiotemporal filtering and the interpolation effect in apparent motion.

A target moving in discrete spatial steps with an appropriate interstep interval (ISI) can appear visually as if it is in continuous motion. The momentary spatial position of such a target is interpolated by the observer between its real physical positions. The extent of this interpolation was measured by a vernier alignment technique, and was found to decrease as the ISI was lengthened. A discretely moving target may be described as a continuously moving target on which is superimposed a periodic modulation of spatial position. It is shown that the traditional "staircase" stimulus for apparent motion can be generalized to include other kinds of periodic modulation. With the use of various analog-filtered and digitally filtered versions of staircase stimuli with different ISIs, it was shown that the pehnomenal interpolation of a periodically modulated moving target was affected only when the frequencies of modulation were less than about 25 Hz. The spatial amplitude of the modulation also has some effect.

Computers↗
PubMed1979

Regulation of the interferon system: evidence that Vero cells have a genetic defect in interferon production.

A clone of Vero cells was isolated and shown to be totally unable to synthesize interferon and insensitive to the toxic effect of poly(rI).poly(rC) treatment. Cells of this clone and mouse L cells were fused by treatment with polyethylene glycol or Sendai virus. Hybrid cell clones were isolated following selection in medium containing hypoxanthine, thymidine and ouabain. The hybrids were sensitive to the antiviral effect of poly(rI).poly(rC) and synthesized mouse, but not primate, interferon. It is proposed that in Vero cells, the gene for interferon synthesis is defective or absent.

Animals↗
PubMed1979

Susceptibility of various cells treated with interferon to the toxic effect of poly(rI).poly(rC) treatment.

Various cells were treated with interferon and then exposed to polyriboinosinic-polyribocytidylic acid complex [poly(rI).poly(rC)]. With mouse L cells, there was a marked cytotoxic effect from low doses of interferon and poly(rI.poly(rC), whereas chick embryo cells showed an effect only after high doses. When primate cells (LLC.Mk2,BSC.B, Vero and human embryo cells) were treated with human or monkey interferon, poly(rI).poly(rC) was not cytotoxic.

Animals↗
PubMed1979

External fixation of facial fractures.

Although external fixation is not indicated in every type of facial fracture, its use alone or with intermaxillary or internal fixation may be of benefit with problems resulting from avulsed segments, infection, inadequate previous reduction, delayed reduction, severe displacement and comminution, non-union, cerebrospinal fluid leak or where a combination of these factors exists. The judicious application of extraskeletal fixation can save valuable anesthetic time as well as assure accesibility of the pharynx and maintenance of an airway and routes for nutrition when these might otherwise be compromised. Although extraskeletal fixation is not withou problems or contraindications, it must be weighed in view of the patient's physical, mental and neurological status, and the existence of concomitant injuries.

Accidents, Traffic↗
PubMed1977

A critical period for social isolation in the rat.

Rats housed in social isolation show heightened levels of object-contact in an open-field and are slower than socially-housed controls to emerge from a small enclosure into an unfamiliar environment. Isolation between 25 and 45 days of age produced an irreversible effect upon object contact but had no lasting effect if between 16 and 25 days or after 45 days. In contrast to object contact, emergence was affected by isolation at any age and the effect was reversed by subsequent social housing. Thus the effects of isolation upon object contact and upon emergence apparently do not depend upon a single underlying variable.

Animals↗