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Biomedical subjects

M J Meyer

Publications and source records attributed to M J Meyer.

At least 19 recordsLinked to original sources
PubMed2002

Effect of protein level in prepartum diets on metabolism and performance of dairy cows.

Multigravid Holstein cows (n = 75) were used in a randomized block design to evaluate the effect of prepartum diets formulated to supply surplus energy and incremental concentrations of protein on the nutritional status of dairy cows at parturition. Cows were blocked according to expected calving date and assigned to one of five diets: 9.7, 11.7, 13.7, 14.7, and 16.2% crude protein (CP). Dietary treatments were initiated 28 d before expected calving date and fed until parturition. A common diet was fed postpartum. Dry matter intake and milk yield were recorded daily through 90 d postpartum. Increasing the protein concentration from 9.7 to 14.7% of dry matter during the last 28 d of gestation improved responses of cows during lactation. Increasing dietary protein up to 14.7% also increased milk yield response to recombinant bovine somatotropin (rbST) during the ninth week of lactation and yields of 305-d 2x mature equivalent milk, milk protein, and milk fat. Plasma aspartate aminotransferase tended to be highest in cows fed 13.7 and 14.7% CP prepartum, but decreased linearly postpartum in response to dietary protein levels. There were no treatment differences for plasma insulin-like growth factor-1 (IGF-1) at d 60 postpartum (before rbST provision), but IGF-1 on d 90 (after rbST provision) was higher in plasma of cows fed 14.7% CP than the other diets except 13.7% CP. Close-up diets containing 13.7% CP and surplus energy produced the most beneficial outcomes during the subsequent lactation.

Animals↗
PubMed2001

Evaluation of wet corn gluten feed in diets for lactating dairy cows.

Two experiments were conducted to evaluate responses of primiparous and multiparous Holstein cows to diets containing wet corn gluten feed (WCGF). In both experiments, WCGF replaced a mix of alfalfa hay, corn silage, and corn grain. In experiment 1, 32 primiparous Holstein cows (four pens with eight cows/pen) were used in two 2 x 2 Latin squares with 28-d periods. Cows were housed in free stalls and fed diets containing 0 or 20% WCGF dry matter (DM) basis. Cows fed WCGF consumed more DM and produced more energy-corrected milk (ECM) than controls. Production efficiency (ECM/DM intake) was not affected, but yield of milk components was improved by WCGF. In experiment 2, 24 multiparous Holstein cows were used in six 4 x 4 Latin squares with 28-d periods to determine the optimal dietary inclusion rate for WCGF. Cows were housed in a tie-stall barn and fed a total mixed ration twice daily. Treatments were 0, 20, 27.5, and 35% WCGF (DM basis). Cows fed WCGF produced more ECM than controls, but ECM did not differ among cows fed WCGF diets. Cows fed 20 and 27.5% WCGF consumed more DM as a percentage of body weight than those fed either 0 or 35% WCGF. Cows fed WCGF produced ECM more efficiently than controls. Percent milk fat was lower, but fat yield was not different when WCGF was added to diets. Milk protein and lactose yields were higher when WCGF was fed. Plasma glucose, alpha-amino N, and triglyceride concentrations were similar among diets in both experiments, but plasma urea N was higher for cows fed WCGF in experiment 2.

Animal Feed↗
PubMed2001

Effect of mechanical processing and fat removal on the nutritive value of cottonseed for lactating dairy cows.

In experiment 1, 24 midlactation, multiparous Holstein cows were used in six 4 x 4 Latin squares to evaluate extruded-expelled cottonseed (EEC) as a source of ruminally undegradable protein (RUP). Diets were formulated to contain: 16% crude protein (CP), 35% RUP (SBM16); 18% CP, 35% RUP (SBM18); 16% CP, 40% RUP using EEC (EC16); and 16% CP, 40% RUP using a fishmeal-blood meal blend (FBM16). Milk yields (37.2 kg/d) and percentages of milk fat, protein, casein, and SNF were similar across diets. Cows fed FBM16 consumed less dry matter (DM) (28.0 kg/d) than those consuming other diets (29.4 kg/d). In experiment 2, 18 midlactation, multiparous Holstein cows were used in six 3 x 3 Latin squares to determine the value of EEC as a replacement for whole cottonseed in lactating cow diets. Diets contained whole cottonseed (CS), EEC plus tallow (ECT), or EEC (EC). Diets were formulated to be similar in energy, N, and RUP. Milk yields (35.5 kg/d), DM intake (27.0 kg/d), and milk fat percent were similar across diets. Percentages of milk protein and SNF were higher for EC than CS or ECT. These production data suggest that EEC can replace whole cottonseed in isocaloric diets and can be partially substituted for soybean meal or a fishmeal-blood meal blend without affecting lactational performance. In situ ruminal degradation and in vitro ammonia N release indicate that processing of EEC was inadequate to protect the protein from ruminal degradation and EEC would not be a source of RUP.

Animal Feed↗
PubMed1998

[Diverticulosis and diverticulitis in the elderly].

Diverticulosis of the colon is a disease that mainly affects the elderly, presenting in 10 to 20% of this age group. The most common complication--painful diverticular disease, is usually treated conservatively with a high-fiber diet, intermittent use of antispasmodics and possibly regulation of the stools. Diagnostic differentiation is best performed using ultrasonography of the bowel wall, supplemented where necessary by computer tomography and colonoscopy (sigmoidoscopy) or, where this latter is not possible, barium enema using Gastrografin. Conservative treatment of diverticulitis with antibiotics, bowel rest, possibly including parenteral alimentation, is usually applied for three to ten days. In the absence of a response to this treatment, frequent recurrence, immunosuppression or complications (perforation, peritonitis, enterovesicular fistula), surgery is indicated.

Aged↗
PubMed1998

Training future leaders of academic medicine: internal programs at three academic health centers.

The authors review the need for internal programs for leadership training at academic health centers and then describe in detail three programs of this type that have operated during the 1990s: (1) the Allegheny Leadership Institute, founded by the Allegheny Health, Education and Research Foundation, Pittsburgh, Pennsylvania; (2) the Physician Executive Management Development Program (PEMDP) of Saint Louis University School of Medicine; and (3) the University of Nebraska Medical Center Leadership Institute. Educational elements common to these programs include having a small class size and participants from many areas of academic medicine and health care, focusing on educational strategies that draw on participants' experiences and training, conducting the training away from the participants' institutions, having short sessions, using faculty from both within and outside the participants' institutions, and creating strategies to reinforce learning. Lessons learned reflect the unique context of each institution; the authors list the major lessons learned by each of the three programs they surveyed (e.g., leaders of the Saint Louis University PEMDP program believe that it is important to help participants implement desired changes in their work areas once they return to work, and are investigating how to do this). The authors conclude with an extensive list of recommendations to optimize the effects of leadership development training carried out in AHCs' internal programs (e.g., "Focus on specific skills that can be learned, and link the learning experiences to real work situations in health care and higher education") and explain why they think internal leadership institutes have at least three distinct advantages over external programs.

Academic Medical Centers↗
PubMed1998

Perceptual differences in fetal alcohol effect boys performing a modeling task.

Perceptual differences were examined for four boys identified with fetal alcohol effect (FAE) and labeled learning disabled for educational purposes. Without a model, all FAE boys built asymmetrical building block designs with no stacking of blocks. When the boys were shown a short videotape of a peer building a simple symmetrical structure with one-layer stacking of blocks, none of the FAE boys successfully imitated. They continued to place blocks randomly on the floor surface with no stacking or layering. This limited study suggests modeling perceptual tasks may not be an effective teaching strategy for children identified with fetal alcohol effect and such children may not be able to learn new skills using demonstration or modeling.

Child↗
PubMed1998

Evaluation of prenatal diagnosis of congenital heart disease.

Prenatal diagnosis performed by fetal ultrasound scan is now a routine part of antenatal care in many countries. That an increasing number of fetal anomalies may be detected on prenatal ultrasound is beyond doubt. What is possible is not, however, always practical, especially where congenital heart diseases (CHDs) are concerned and when whole antenatal populations are screened rather than high risk groups. Thanks to our registries of congenital anomalies, a retrospective study was undertaken to evaluate the prenatal detection of CHDs by ultrasound scan in 92,021 consecutive pregnancies of known outcome from 1990 to 1993. Only 107 out of 779 malformed fetuses with CHDs without chromosomal anomalies were detected (13.7 per cent). The sensitivity of detection varied from 50 per cent for malformations, such as hypoplastic left heart and single ventricle, to around 5 per cent for ventricular and atrial septal defects. The effectiveness of the detection of some forms of major congenital heart disease has increased since 1987 by including routine examination of the four-chamber view and of the inflow and outflow tracts of the fetal heart. Our results stress the need to obtain a definite, clear, four-chamber view, to perform scans at > 18 weeks' gestation and to train sonographers in order to improve prenatal detection of CHDs.

Abnormalities, Multiple↗
PubMed1996

Protein adduct biomarkers: state of the art.

Covalent protein adducts formed after exposure to xenobiotics may provide readily measurable indicators of these exposures. After adequate characterization of the dose-dependent formation of a specific adduct, the adduct can often be used as a quantitative marker for exposure, DNA adduct formation, or, possibly, risk of disease. By elucidating the structure of an adduct and studying the conditions under which it forms, information about the reactions that lead to its formation can be obtained. Continuing work in this area includes methods to expand the number, types, and levels of chemical exposures that can be studied by covalent adduct formation. In addition to the use of this technology in the field of occupational health, basic research in this area provides insights into metabolic pathways and biochemistry, as well.

Biomarkers↗
PubMed1992

Patients' duties.

This paper argues that patients' duties are derivable from the idea which typically grounds the idea of patients' rights: patient autonomy. The autonomous patient, joined in partnership with the health care professional, has self-regarding obligations and obligations to others, including health care professionals. Patients' duties include, but are not limited to: a duty to be honest about why the patient seeks care; a duty to collect information on available treatments and likely side-effects; a duty for a patient who has an infectious condition to act on that information which can best prevent further transmission.

Codes of Ethics↗
PubMed1992

Morphology of the mineralizing front and observations of reparative dentine following induction and inhibition of dentinogenesis in the rat incisor.

An extra oral approach was made to 26 pairs of Wistar rat incisors and a small bur used to expose the pulps which were then dressed with either calcium hydroxide paste (Pulpdent) zinc oxide-eugenol cement (Kalzinol) or a triamocinolone acetonide/tetracycline containing cement (Ledermix). Animals were sacrificed at 7 days, incisors removed, a window cut to the pulp opposite the site of exposure, soft tissues removed with 7% NaOCl for 30 minutes before teeth were dehydrated in graded concentrations of acetone and gold coated for examination under SEM. Calcium hydroxide produced rapid complete repair with a remarkably regular formation of calcospherites, except for a zone of relative inhibition perforated by nutrient canals at the periphery of each lesion. Both zinc oxide-eugenol and triamcinolone acetonide cements inhibited both bridging of the defect created by the exposure and dentine formation in the surrounding pulpal wall. Data was grouped according to the degree of hard tissue repair. The results were statistically significant (Chi-square p < or = 0.001). This method demonstrated qualitative and quantitative differences in the repair process resulting from chemical variations in the dressings applied.

Animals↗
PubMed1992

Symmetry in building block design for learning disabled and nonlearning disabled boys.

This study examined perceptual differences in symmetry with and without a model between 21 learning disabled boys with reading deficits and 28 learning disabled boys with deficits in mathematics. 55 nonlearning disabled boys served as controls. All boys were in Grades 3, 4, or 5. Without a model, all learning disabled boys built significantly more asymmetrical building block designs than nonlearning disabled boys. However, with a model, all learning disabled boys could imitate the model, but it took them longer to complete the task successfully. All boys appeared to have difficulty in modeling asymmetrical tasks, taking more time for task completion after seeing an asymmetrical model. This study suggests modeling perceptual tasks might be an effective teaching strategy for such children.

Attention↗
PubMed1987

Self-regulation of stimulation for ADD-H children during reading and vigilance task performance.

The present study examines the hypothesis that motor responses added into rote tasks would modulate the sensation-seeking activity and impulsive errors of hyperactive (ADD-H) children. To this purpose 22 ADD-H and 25 comparison children were administered two repetitive tasks (word decoding and an auditory vigilance task) under both an active response and a passive response condition. Findings were that the impulsive errors, talking/noisemaking, and activity of ADD-H children was normalized (i.e., did not differ from comparison children) only in the high stimulation active response conditions. Behavioral improvements for ADD-H children were documented in both tasks in the active condition, but performance gains were found only in the vigilance task. The findings supported predictions derived from the optimal stimulation theory that the excessive activity and attraction to novel stimuli of ADD-H children can be channeled into appropriate instrumental motor and attention responses.

Arousal↗
PubMed1984

[Gyrate atrophy of the choroid and retina in children. Apropos of 2 cases].

The authors report two familial cases of algerian children with a hyperornithinaemia and a gyrate atrophy. Blood ornithine was 10 to 20 above the normal, lysine and glutamic acid were slightly decreased. Urinary ornithine levels were very high. The enzymatic activity of the ornithine keto-acid transaminase was not detectable in the patients skin fibroblasts. It was more than half the normal value in the children's mother. Owing to a better knowledge of the biochemical abnormalities a poor protein, poor arginine and more recently proline added diet has been recommended in order to alter the development of ocular lesions. Unfortunately the authors did not have the opportunity of following the children long enough to assess the result of this treatment.

Algeria↗