Search PubMed⌕ Search

Biomedical subjects

M J Merino

Publications and source records attributed to M J Merino.

At least 181 records · Page 10Linked to original sources
PubMed1983

Warty dyskeratoma of the vulva.

Suprabasal acantholysis of the epidermis is a histopathologic common denominator of diverse conditions such as pemphigus vulgaris, benign familial pemphigus (Hailey-Hailey), transient acantholytic dermatosis (Grover's disease), some actinic keratoses and cutaneous squamous carcinomas, keratosis follicularis (Darier's disease [DD]), and warty dyskeratoma (WD). Of these, WD rarely occurs in the vulva and is indistinguishable histologically from DD. However, DD is an inherited dermatosis (autosomal dominant) consisting of multiple keratotic papules on the face, trunk, and extremities, while WD occurs as an isolated, noninherited, single keratotic nodule mainly confined to the head and neck. We had the opportunity to study three patients who presented with isolated WD in the vulva. These patients had no other skin lesions and had no family history of DD or multiple dermatologic papulonodules. Histologically, all three vulvar lesions were indistinguishable from classic head and neck WD. WD must be clinically and histologically differentiated from vulvar dysplasia, bowenoid papulosis, squamous carcinoma, condyloma, and other viral-induced squamous lesions. WD should be added to the list of recognizable vulvar squamous lesions.

Acantholysis↗
PubMed1982

Oncocytomas of the kidney.

Fourteen cases of renal oncocytomas are presented. By definition these lesions are composed entirely of pink eosinophilic cells with abundant granular cytoplasm. No evidence of mitotic activity or necrosis was seen in any of the cases, although focal areas of nuclear pleomorphism were identified in two cases. Clinically the patients have remained asymptomatic and without evidence of metastatic or recurrent disease in a follow-up that ranges from 1-14 years. The clinical behavior of these tumors favors the benign nature of the lesion regardless of the tumor size.

Adenoma↗
PubMed1982

Adenoid basal cell carcinoma of the vulva.

Two cases of a subtype of basal cell carcinoma--the adenoid basal cell type--occurring in the vulva, are described. These lesions are frequently misdiagnosed as adenoid cystic carcinomas of the Bartholin's gland because of their histologic appearance. Their characteristic presentation, histology, and prognosis warrant their differentiation.

Aged↗
PubMed1981

Signet ring carcinoma of the female breast: a clinicopathologic analysis of 24 cases.

Signet ring carcinomas of the breast have been separated recently as an aggressive subtype of breast cancer, distinct from mucinous (colloid) carcinomas. Twenty-four cases of signet ring breast cancer (2% of total breast cancers at the authors' institution) were analyzed. The authors' study indicates that histogenetically such lesions are derived from lobular, not ductal, cells since mucin patterns and ultrastructural features are shared. In addition, in each of our 24 cases, infiltrating lobular carcinoma was identified; in 11 of these (46%) lobular carcinoma in-situ (LCIS) was also noted. Signet ring carcinomas show an unusual metastatic pattern with a propensity to involve serosal surfaces and mimicking gastrointestinal disease or retroperitoneal fibrosis. These tumors are associated with a poor prognosis, with 60% of our 24 patients dead of disease at 7 years. The distinctive clinical and pathologic features of signet ring carcinoma warrant separation of this group of tumors from other forms of breast cancer.

Adenocarcinoma, Mucinous↗
PubMed1981

Malignant carotid body tumors: report of two cases and review of the literature.

Paragangliomas may arise in any area of the body where nonchromaffin paraganglia are situated. These include the glomus jugulare, the carotid body, and the retroperitoneum. Malignant behavior of these paragangliomas has been a controversial subject with most authors, who consider them to be benign tumors. Some authors have diagnosed locally recurrent and infiltrative tumors as malignant, whereas most require the demonstration of metastatic potential as the only criterion for malignancy. Two cases of metastasizing carotid body tumors are reported with a review of the literature on this unusual neoplasm.

Adult↗
PubMed1981

Elastofibroma dorsi: an immunochemical study of collagen content.

The types of collagen present in a case of elastofibroma dorsi were determined using type specific, characterized collagen antibodies. The presence of type II collagen (normally present only in articular cartilage and in selected ocular structures) is discussed with regard to the pathogenesis of this lesion, and the use of collagen antibodies is discussed with regard to their potential value in better characterizing and classifying mesenchymal tumors.

Collagen↗
PubMed1981

Pseudolymphoma of the breast.

A case of pseudolymphoma of the breast presenting as an isolated tumor mass in the breast of a 56-year-old female is described. Recognition of this rare lesion is important in order to differentiate it from other malignant neoplasms.

Breast Neoplasms↗
PubMed1980

Inflammatory malignant fibrous histiocytoma.

This report describes a 13-year-old girl with inflammatory malignant fibrous histiocytoma of the abdomen. Clinical, pathologic, and ultrastructural features of this subgroup of tumors are discussed. Differential diagnostic criteria are reviewed.

Abdominal Neoplasms↗
PubMed1980

Fibrothecoma of the broad ligament.

We present a patient with a primary extraovarian fibrothecoma, an extremely rare lesion originating in the broad ligament. Possible sources of origin and significance are discussed.

Adnexa Uteri↗
PubMed1978

Squamous cells in the human thyroid gland.

Squamous epithelium in the thyroid, which may be basaloid, epidermoid, or truly squamous, may be derived from several sources. In the normal thyroid, usually rests of one type or another are responsible for these cell nests. Thus, thymic or ultimobranchial remanants may be found in the lateral lobes of normal thyroid glands. Maldevelopment or excessive descent of thyro-glossal duct remnants may be responsible for squamous epithelial cysts noted in the central portions of the thymus, especially in the isthmus. In diseased thyroids, the most likely derivation of squamous or epidermoid epithelium is through metaplasia of follicular epithelial cells. Thus, in adenomatous goiter and various types of thyroiditis as well as follicular derived neoplasms, such a derivation is most likely. In tumors containing malignant squamous epithelium (adenoacanthoma, adenosquamous carcinoma, or pure squamous carcinoma) there is a range of such lesions, and since many of them appear to be derived from follicular epithelium, it is most likely that squamous metaplasia which has undergone malignant transformation has occurred in these neoplasms.

Adult↗