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Biomedical subjects

M J Leboutet

Publications and source records attributed to M J Leboutet.

At least 73 records · Page 4Linked to original sources
PubMed1981

N-Hexane- and methylethylketone-induced polyneuropathy. Abnormal accumulation of glycogen in unmyelinated axons. Report of a case.

This report presents the ultrastructural nerve study of a patient with sensorimotor neuropathy by a shoe glue containing an association of n-hexane and methylethylketone. Giant axons, distended by microfilamentous proliferation typical of such cases of neuropathy, were found in significant amounts. An unusual histological feature of this case was the considerable distension by a marked accumulation of glycogen granules in certain unmyelinated axons. Such a lesion has never been described in neuropathy induced by industrial agents.

Adult↗
PubMed1981

[Ultrastructural and experimental study of the ocular toxicity of antibiotics and antifungals on the corneal endothelium (author's transl)].

The authors report an experimental study on the ocular toxicity of some antibiotics (ampicillin, gentamicin, cephalotin sodic, tobramycin) and some antifungals (amphotericin B, flucytosin). For this study they used both the transmission electron microscope and the scanning microscope. The most important modifications of the corneal endothelium were observed with amphotericin b, flucytosin. cephalotin sodic. The toxicity seems to be lower with gentamicin and with tobramycin. Ampicillin produced few visible changes. This study was realized with the aim to determine the quantities of antimicrobials that could be injected in the human eye without corneal lesions in the treatment of endophthalmitis (bacterial or fungal).

Animals↗
PubMed1980

Cryoglobulinemic neuropathy: a pathological study.

A 53-year-old woman developed symmetrical polyneuropathy of the lower limbs a few months after she was found to have myeloma with cryoglobulinemia. In musculocutaneous nerve biopsy material, electron microscopy showed both axonal degeneration and demyelination. The most striking finding was the presence, in the endoneurial space, of numerous masses of closely packed tubular structures. These masses also were found in the walls of all the vasa nervorum and within the lumen of some vessels. The morphological features and dimensions of the deposits within nerve were identical to those of cryoprecipitates extracted from serum and examined with the electron microscope. An example of myeloma neuropathy with cryoglobulin deposits within the endoneurial space has not been reported previously.

Biopsy↗
PubMed1980

[Scanning electron microscopic study of the effect of some intraocular irrigating solutions on the corneal endothelium].

The effects of two intraocular irrigating solutions (physiological saline, Mac Carey-Kaufman medium) on the corneal endothelium of the rabbit have been evaluated by scanning electron microscopy. During an experimental anterior vitrectomy on aphakic rabbit eyes, corneas were perfused with a different solution in each eye during a period of up to 75 min and with a maximum of 250 cm3 of liquid. We found a significant difference only after 60 min of perfusion at which time important lesions appeared in the cornea of eyes perfused with physiological saline. The corneas irrigated with Mac Carey-Kaufman medium remained normal.

Animals↗
PubMed1980

[Ultrastructural aspect of the different levels of the lacrimal system (author's transl)].

Using the transmission electron microscope and the scanning electron microscope, we have found a different ultrastructure at the different levels of the lacrimal system: 1) tarsal conjonctiva: numerous microvilli on a relief of small valleys; 2) lacrimal punctum: the surface of the cell is flat with sparse microvillosti, sparse cilia and strong intercellular junction; 3) external part of the canaliculus: pavement epithelium with numerous microvillositi and pinocytosis, absence of cilia; 4) internal part of the canaliculus: the microvillositi are very small or absent; 5) lacrimal sac: the cilia are arranged by tufts scattered on this malpighian epithelium; 6) nasolacrimal duct: the cilia are numerous; 7) in the nose the cilia are extremely numerous.

Cilia↗
PubMed1978

Hemosiderin deposition in muscle. Report of three cases.

This report presents the morphological character of iron deposits in muscle biopsies of three patients who have been suffering from secondary hemochromatosis. The granules observed by light microscopy and located either in the cytoplasm of macrophages or inside muscle fibres are illustrated in electron micrographs. In this study, Thiery's technic, which is a specific and very sensitive reaction, has been very useful to confirm by electron microscopy that these granules contain iron. Such a study in muscle appears to be unique. In our experience, accumulation of hemosiderin pigment in muscle does not seem to be specific of any disease but suggests that a hepatic biopsy must be done.

Adult↗