Seeing for themselves.
Explore the source record for details and available documents.
Education, Medical, Undergraduate↗
Biomedical subjects
M J Kelly
Publications and source records attributed to M J Kelly.
Central nervous system noradrenergic control of sympathetic outflow in normotensive and hypertensive humans.
We applied transmitter washout methodology, sampling internal jugular venous plasma via a percutaneously placed catheter, to study CNS norepinephrine release in humans and its relation to peripheral sympathetic activity. Norepinephrine overflows into the venous drainage of the brain, as do its precursor, DOPA, and metabolites DHPG and MHPG, indicating that the blood-brain barrier provides an incomplete impediment to their outward flux from the brain. Pharmacological testing with two drugs which altered CNS norepinephrine turnover, the tricyclic antidepressant desipramine and the ganglionic blocker, trimethaphan, demonstrated a direct relation existed between CNS norepinephrine release and sympathetic nerve firing rates. In essential hypertension, the sympathetic activation commonly present was associated with, and possibly caused by increased CNS release of norepinephrine, manifested in elevated overflow of norepinephrine, MHPG and DHPG from the brain. Bilateral jugular sampling, coupled with a cerebral venous sinus scan to delineate the drainage pattern, demonstrated that this increased norepinephrine release was confined to subcortical forebrain regions.
Blood Pressure↗
Should competence be coerced?
Explore the source record for details and available documents.
Antipsychotic Agents↗
Control of heart rate during movement in acute myocardial infarction.
Among patients with acute myocardial infarction and a normal heart rate and blood pressure, a high incidence of sympathetic overactivity was recorded during transport. The combined administration of atropine and sotalol had no significant effect on the mean maximum heart rate on movement. However, this drug combination prevented excessive slowing of the heart rate. Sotalol caused a significant reduction in the mean maximum heart rate on movement. The side-effects were minimal. 10% of patients who received sotalol required atropine for the correction of bradyarrhythmia.
Adult↗
Stress and diseases of the upper gut: II. Stress and pancreatic disease.
Explore the source record for details and available documents.
Acute Disease↗
Stress and diseases of the upper gut: III. Gallbladder disease.
Explore the source record for details and available documents.
Acute Disease↗
Evidence for the presence of vascular dopamine receptors in the rabbit.
In vitro experiments, using dopamine-induced relaxations of several pre-contracted rabbit blood vessels, confirmed the presence of renal dopamine receptors and suggested the existence of similar receptors in the portal vein and aorta. With jejunal muscle, however, dopamine's (spontaneous) relaxant effect was mediated by beta-adrenoceptors. The relaxant responses in the blood vessels were small, and quantitative information proved difficult to obtain. Therefore, a method of measuring alpha-adrenoceptor mediated contractile responses to dopamine was developed. Comparison of the respective antagonism of these responses produced by an alpha-adrenoceptor antagonist, phentolamine, and a dopamine receptor antagonist, haloperidol, showed differences between vascular and intestinal smooth muscle. The results suggest that this method is able to detect the presence of dopamine receptors in isolated tissues.
Animals↗
Endometriosis--the problems of intestinal obstruction.
Endometriosis is a relatively common condition in women of child-bearing age, and coincidental intestinal serosal involvement is frequently recognised. However, intestinal obstruction, although reported, is rare. We report what we believe is the first case with synchronous ileo-caecal and rectosigmoid obstructing endometriomas. Endometriosis as a cause of bowel obstruction is discussed and in particular the differential diagnosis from Crohn's disease and malignancy.
Adult↗