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Biomedical subjects

M J Jesse

Publications and source records attributed to M J Jesse.

At least 37 records · Page 2Linked to original sources
PubMed1977

Lung mechanics in congenital heart disease with increased and decreased pulmonary blood flow.

Respiratory rate, tidal volume, dynamic lung compliance, functional residual capacity, and pulmonary resistance were measured withim 24 hours of cardiac catheterization in 25 infants, 12 of whom had increased pulmonary blood flow and 13 of whom had decreased PBF. There were no differences in the two groups of patients with respect to VT and FRC. Respiratory rate and pulmonary resistance were higher in infants with increased PBF. Lung compliance was significantly lower in infants with increased PBF (4.9 ml/cm H2O) than in those with decreased PBF (8.9 ml/cm H2O) (P less than 0.01). The decrease in CL in infants with increased PBF significantly correlated with mean pulmonary artery pressure (r = 0.798). No correaltion was found between CL and left atrial pressure or magnitude of the left-to-right shunt. Compliance was normal in patients with increased PBF and normal PAP, suggesting that PAP and not PBF is the primary factor that affects CL in patients with intracardiac left-to-right shunts.

Airway Resistance↗
PubMed1977

A retrospective study of physical activity and coronary deaths.

For a series of 568 married white men aged 30-70 years who died from coronary heart diseases, (CHD), and a matched sample of living neighbourhood controls, information was collected on a large number of variables, including physical activity, (PA), classified according to the Health Insurance Plan Study criteria. Increased leisure PA was associated with a decreased risk of coronary death (p less than .001) but there was no association between job activity and coronary deaths. Step-up multiple regression, based on within-pair differences, was used to control for the possible confounding effects of all variables studied. Even when these variables were controlled for there was still a significant association between increased leisure PA and decreased risk of death due to CHD (P less than .001). These data are consistent with the hypothesis that increased leisure PA can contribute to the prevention of death from CHD.

Adult↗
PubMed1976

Coffee drinking and death due to coronary heart disease.

For a series of 649 patients who died of coronary heart disease within 24 hours of onset of symptoms, and an equal number of neighborhood controls, information was obtained on a large number of variables, including coffee consumption. An analysis using multivariate risk scores to control for all available variables yields a maximum likelihood estimate of the risk ratio associated with coffee drinking of 1.1 (95 per cent two-sided confidence limits, 0.8 to 1.6). The estimate of the risk ratio depends somewhat on the number and nature of variables controlled for in the analysis. Overall, our findings, limited to low-risk and middle-risk patients, suggest that the risk, if any, of death from coronary heart disease associated with coffee drinking is small.

Adult↗
PubMed1976

Aggregation of blood pressure in infants and their siblings.

Sibling aggregation of blood pressure has been shown in children 2 to 14 years of age. To determine the earliest age at which this finding is detectable, blood pressures were evaluated in 98 siblings from 43 black families with newborns. Variances of blood pressure scores were significantly greater among families than within families for systolic (p less than .025) but not diastolic pressures. Sib-sib intraclass correlation coefficients were .26 (95% two-sided confidence limits .05 to .47) for systolic and .16 (-.06 to .38) for diastolic pressures. When 1-month-old infant pressures were added, significant aggregation was present for systolic (p less than .01) and diastolic (p less than .025) pressures. The intraclass correlation coefficients were .21 (.02 to .38) and .17 (.03 to .34), respectively. When newborn scores were substituted, aggregation was not demonstrable. These data demonstrate a familial influence on blood pressure in infancy by 1 month of age.

Adolescent↗
PubMed1976

Cholesterol among children of men with myocardial infarction.

Plasma cholesterol levels were obtained on 90 children of 39 men with premature myocardial infarction and 86 children of 39 healthy men. The mean cholesterol among children of affected men (195.1 mg/100 ml) was higher than among children of healthy men (176.6 mg/100 ml) (P equal to .009). Higher mean levels were demonstrable at each of nine age groups from 1 to 21 years(P equal to .004). Levels greater than 230 mg/100 ml were found in 16.7% of children of affected fathers and 4.7% of children of healthy fathers, a ratio of 3.6 to 1 (P equal to .01). These findings are compatible with the hypothesis that elevated childhood cholesterol level offers a mechanism whereby family history predicts coronary disease. A dip in cholesterol during adolescence, a finding that varies with population studied, was demonstratable among children of both affected healthy men.

Adolescent↗
PubMed1975

Risk factors for coronary artery disease in children of affected families.

Risk factors for coronary artery disease were present to a greater degree in children of men who had experienced premature myocardial infarction when compared to children of unaffected male parents. Levels of cholesterol and body weight, as well as family history of premature CAD, differed significantly between the groups of children. The chance of identifying a child with hyperlipidemia was three times greater if the father had premature CAD. Data regarding familial aggregation of risk factors for CAD are reviewed and their significance discussed.

Adolescent↗
PubMed1975

Left subclavian steal, interrupted aortic arch, complete transposition of the great vessels and single left ventricle.

Congenital subclavian steal consists of atresia of the proximal end of the subclavian artery, while the blood supply to the distal portion of the subclavian artery originates from the circle of Willis. It should be suspected in complicated malformations of the heart associated with marked hypoplasia or interruption of the aortic arch. Minimal differences in blood pressure determinations may be an important clue in the diagnosis of this anomaly. The diagnosis may be confirmed by angiography with careful attention to late arterial phase films.

Abnormalities, Multiple↗