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Biomedical subjects

M J Goodfield

Publications and source records attributed to M J Goodfield.

56 records · Page 4Linked to original sources

Trichophyton tonsurans tinea capitis and tinea corporis: treatment and follow-up of four affected family members.

We report a Caucasian family of two veterinary practitioners and their two children, ages 2 years and 6 months, simultaneously infected with the dermatophyte Trichophyton tonsurans, causing tinea capitis and tinea corporis in the children and tinea corporis in the parents. The parents and older child were successfully treated with oral terbinafine. The infant clinically responded to treatment with topical terbinafine and ketoconazole shampoo but presented with recurrent tinea capitis 12 months later, from which T. tonsurans was cultured. At this time, scalpbrush samples from the other family members failed to culture any fungi, and neither were fungi isolated from the family hairbrushes. The infant then received oral terbinafine, resulting in clinical and mycologic cure. After a further 12 months follow-up, there has been no mycologic evidence of recurrence in any family member.

Administration, Oral↗

Increased platelet sensitivity to collagen-induced aggregation in whole blood patients with systemic sclerosis.

Platelet aggregation in whole blood was investigated in patients with Systemic sclerosis and age- and sex-matched controls. Dose-response curves for collagen, adrenaline and ADP-induced fall in platelet count were constructed. Aggregation to collagen at all concentrations was significantly greater (p less than 0.01) in the patients with systemic sclerosis than the normal controls, with a four-fold reduction in the ED50 for SS (0.044 +/- 0.03 mcg/1) compared with controls (0.12 +/- 0.008 mcg/1). No significant difference was observed in the response to the other aggregating agents, thus suggesting that in this disease a platelet abnormality exists which is specific for collagen. Increased platelet responsiveness to collagen and hence increased release of platelet-derived growth factors may provide a lin between endothelial damage and the connective tissue fibrosis of systemic sclerosis.

Adult↗